Neurological complications and infection mechanism of SARS-COV-2

Abstract Currently, SARS-CoV-2 has caused a global pandemic and threatened many lives. Although SARS-CoV-2 mainly causes respiratory diseases, growing data indicate that SARS-CoV-2 can also invade the central nervous system (CNS) and peripheral nervous system (PNS) causing multiple neurological dise...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dandan Wan, Tingfu Du, Weiqi Hong, Li Chen, Haiying Que, Shuaiyao Lu, Xiaozhong Peng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Medicine R Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d8bcff38e3284e018f0e9df47a448382
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d8bcff38e3284e018f0e9df47a448382
record_format	dspace
spelling	oai:doaj.org-article:d8bcff38e3284e018f0e9df47a4483822021-11-28T12:08:38ZNeurological complications and infection mechanism of SARS-COV-210.1038/s41392-021-00818-72059-3635https://doaj.org/article/d8bcff38e3284e018f0e9df47a4483822021-11-01T00:00:00Zhttps://doi.org/10.1038/s41392-021-00818-7https://doaj.org/toc/2059-3635Abstract Currently, SARS-CoV-2 has caused a global pandemic and threatened many lives. Although SARS-CoV-2 mainly causes respiratory diseases, growing data indicate that SARS-CoV-2 can also invade the central nervous system (CNS) and peripheral nervous system (PNS) causing multiple neurological diseases, such as encephalitis, encephalopathy, Guillain-Barré syndrome, meningitis, and skeletal muscular symptoms. Despite the increasing incidences of clinical neurological complications of SARS-CoV-2, the precise neuroinvasion mechanisms of SARS-CoV-2 have not been fully established. In this review, we primarily describe the clinical neurological complications associated with SARS-CoV-2 and discuss the potential mechanisms through which SARS-CoV-2 invades the brain based on the current evidence. Finally, we summarize the experimental models were used to study SARS-CoV-2 neuroinvasion. These data form the basis for studies on the significance of SARS-CoV-2 infection in the brain.Dandan WanTingfu DuWeiqi HongLi ChenHaiying QueShuaiyao LuXiaozhong PengNature Publishing GrouparticleMedicineRBiology (General)QH301-705.5ENSignal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Biology (General) QH301-705.5
spellingShingle	Medicine R Biology (General) QH301-705.5 Dandan Wan Tingfu Du Weiqi Hong Li Chen Haiying Que Shuaiyao Lu Xiaozhong Peng Neurological complications and infection mechanism of SARS-COV-2
description	Abstract Currently, SARS-CoV-2 has caused a global pandemic and threatened many lives. Although SARS-CoV-2 mainly causes respiratory diseases, growing data indicate that SARS-CoV-2 can also invade the central nervous system (CNS) and peripheral nervous system (PNS) causing multiple neurological diseases, such as encephalitis, encephalopathy, Guillain-Barré syndrome, meningitis, and skeletal muscular symptoms. Despite the increasing incidences of clinical neurological complications of SARS-CoV-2, the precise neuroinvasion mechanisms of SARS-CoV-2 have not been fully established. In this review, we primarily describe the clinical neurological complications associated with SARS-CoV-2 and discuss the potential mechanisms through which SARS-CoV-2 invades the brain based on the current evidence. Finally, we summarize the experimental models were used to study SARS-CoV-2 neuroinvasion. These data form the basis for studies on the significance of SARS-CoV-2 infection in the brain.
format	article
author	Dandan Wan Tingfu Du Weiqi Hong Li Chen Haiying Que Shuaiyao Lu Xiaozhong Peng
author_facet	Dandan Wan Tingfu Du Weiqi Hong Li Chen Haiying Que Shuaiyao Lu Xiaozhong Peng
author_sort	Dandan Wan
title	Neurological complications and infection mechanism of SARS-COV-2
title_short	Neurological complications and infection mechanism of SARS-COV-2
title_full	Neurological complications and infection mechanism of SARS-COV-2
title_fullStr	Neurological complications and infection mechanism of SARS-COV-2
title_full_unstemmed	Neurological complications and infection mechanism of SARS-COV-2
title_sort	neurological complications and infection mechanism of sars-cov-2
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/d8bcff38e3284e018f0e9df47a448382
work_keys_str_mv	AT dandanwan neurologicalcomplicationsandinfectionmechanismofsarscov2 AT tingfudu neurologicalcomplicationsandinfectionmechanismofsarscov2 AT weiqihong neurologicalcomplicationsandinfectionmechanismofsarscov2 AT lichen neurologicalcomplicationsandinfectionmechanismofsarscov2 AT haiyingque neurologicalcomplicationsandinfectionmechanismofsarscov2 AT shuaiyaolu neurologicalcomplicationsandinfectionmechanismofsarscov2 AT xiaozhongpeng neurologicalcomplicationsandinfectionmechanismofsarscov2
_version_	1718408228228825088

Neurological complications and infection mechanism of SARS-COV-2

Ejemplares similares