The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche

How hormonal signaling in the mammary epithelium controls the surrounding extracellular matrix is unclear. Here, the authors show that a secreted protease, Adamts18, induced by upstream estrogen-progesterone activated Wnt4 in myoepithelial cells, remodels the basement membrane and contributes to mam...

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Autores principales:	Dalya Ataca, Patrick Aouad, Céline Constantin, Csaba Laszlo, Manfred Beleut, Marie Shamseddin, Renuga Devi Rajaram, Rachel Jeitziner, Timothy J. Mead, Marian Caikovski, Philipp Bucher, Giovanna Ambrosini, Suneel S. Apte, Cathrin Brisken
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d8bdc001db1a46d1897587347f7e2b51
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spelling	oai:doaj.org-article:d8bdc001db1a46d1897587347f7e2b512021-12-02T14:42:49ZThe secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche10.1038/s41467-020-15357-y2041-1723https://doaj.org/article/d8bdc001db1a46d1897587347f7e2b512020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15357-yhttps://doaj.org/toc/2041-1723How hormonal signaling in the mammary epithelium controls the surrounding extracellular matrix is unclear. Here, the authors show that a secreted protease, Adamts18, induced by upstream estrogen-progesterone activated Wnt4 in myoepithelial cells, remodels the basement membrane and contributes to mammary epithelial stemness.Dalya AtacaPatrick AouadCéline ConstantinCsaba LaszloManfred BeleutMarie ShamseddinRenuga Devi RajaramRachel JeitzinerTimothy J. MeadMarian CaikovskiPhilipp BucherGiovanna AmbrosiniSuneel S. ApteCathrin BriskenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dalya Ataca Patrick Aouad Céline Constantin Csaba Laszlo Manfred Beleut Marie Shamseddin Renuga Devi Rajaram Rachel Jeitziner Timothy J. Mead Marian Caikovski Philipp Bucher Giovanna Ambrosini Suneel S. Apte Cathrin Brisken The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche
description	How hormonal signaling in the mammary epithelium controls the surrounding extracellular matrix is unclear. Here, the authors show that a secreted protease, Adamts18, induced by upstream estrogen-progesterone activated Wnt4 in myoepithelial cells, remodels the basement membrane and contributes to mammary epithelial stemness.
format	article
author	Dalya Ataca Patrick Aouad Céline Constantin Csaba Laszlo Manfred Beleut Marie Shamseddin Renuga Devi Rajaram Rachel Jeitziner Timothy J. Mead Marian Caikovski Philipp Bucher Giovanna Ambrosini Suneel S. Apte Cathrin Brisken
author_facet	Dalya Ataca Patrick Aouad Céline Constantin Csaba Laszlo Manfred Beleut Marie Shamseddin Renuga Devi Rajaram Rachel Jeitziner Timothy J. Mead Marian Caikovski Philipp Bucher Giovanna Ambrosini Suneel S. Apte Cathrin Brisken
author_sort	Dalya Ataca
title	The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche
title_short	The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche
title_full	The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche
title_fullStr	The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche
title_full_unstemmed	The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche
title_sort	secreted protease adamts18 links hormone action to activation of the mammary stem cell niche
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d8bdc001db1a46d1897587347f7e2b51
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The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche

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