Engineering protein-protein devices for multilayered regulation of mRNA translation using orthogonal proteases in mammalian cells

RNA-encoded regulatory circuits are desirable because they do not integrate in the host and are less immunogenic, but the availability of regulatory devices is limited. Here the authors develop viral protease RNA-binding proteins and protease–protease genetic circuits that ultimately regulate mRNA t...

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Autores principales:	Federica Cella, Liliana Wroblewska, Ron Weiss, Velia Siciliano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d8c7754433284bdbb7c17a57891051a8
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spelling	oai:doaj.org-article:d8c7754433284bdbb7c17a57891051a82021-12-02T17:32:01ZEngineering protein-protein devices for multilayered regulation of mRNA translation using orthogonal proteases in mammalian cells10.1038/s41467-018-06825-72041-1723https://doaj.org/article/d8c7754433284bdbb7c17a57891051a82018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06825-7https://doaj.org/toc/2041-1723RNA-encoded regulatory circuits are desirable because they do not integrate in the host and are less immunogenic, but the availability of regulatory devices is limited. Here the authors develop viral protease RNA-binding proteins and protease–protease genetic circuits that ultimately regulate mRNA translation.Federica CellaLiliana WroblewskaRon WeissVelia SicilianoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Federica Cella Liliana Wroblewska Ron Weiss Velia Siciliano Engineering protein-protein devices for multilayered regulation of mRNA translation using orthogonal proteases in mammalian cells
description	RNA-encoded regulatory circuits are desirable because they do not integrate in the host and are less immunogenic, but the availability of regulatory devices is limited. Here the authors develop viral protease RNA-binding proteins and protease–protease genetic circuits that ultimately regulate mRNA translation.
format	article
author	Federica Cella Liliana Wroblewska Ron Weiss Velia Siciliano
author_facet	Federica Cella Liliana Wroblewska Ron Weiss Velia Siciliano
author_sort	Federica Cella
title	Engineering protein-protein devices for multilayered regulation of mRNA translation using orthogonal proteases in mammalian cells
title_short	Engineering protein-protein devices for multilayered regulation of mRNA translation using orthogonal proteases in mammalian cells
title_full	Engineering protein-protein devices for multilayered regulation of mRNA translation using orthogonal proteases in mammalian cells
title_fullStr	Engineering protein-protein devices for multilayered regulation of mRNA translation using orthogonal proteases in mammalian cells
title_full_unstemmed	Engineering protein-protein devices for multilayered regulation of mRNA translation using orthogonal proteases in mammalian cells
title_sort	engineering protein-protein devices for multilayered regulation of mrna translation using orthogonal proteases in mammalian cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d8c7754433284bdbb7c17a57891051a8
work_keys_str_mv	AT federicacella engineeringproteinproteindevicesformultilayeredregulationofmrnatranslationusingorthogonalproteasesinmammaliancells AT lilianawroblewska engineeringproteinproteindevicesformultilayeredregulationofmrnatranslationusingorthogonalproteasesinmammaliancells AT ronweiss engineeringproteinproteindevicesformultilayeredregulationofmrnatranslationusingorthogonalproteasesinmammaliancells AT veliasiciliano engineeringproteinproteindevicesformultilayeredregulationofmrnatranslationusingorthogonalproteasesinmammaliancells
_version_	1718380461577732096

Engineering protein-protein devices for multilayered regulation of mRNA translation using orthogonal proteases in mammalian cells

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