Colorectal Cancer associated with pediatric inflammatory bowel disease: a case series

Abstract Background Inflammatory bowel disease (IBD) is associated with an increased risk of Colorectal cancer (CRC), and its most important risk factors are the duration and extent of the disease. Pediatric-onset inflammatory bowel disease has a tendency for a more extensive, more severe, and longe...

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Autores principales:	Min Jee Kim, Jae Sung Ko, Minsoo Shin, Jong Woo Hahn, Soo Young Moon, Hyun Young Kim, Jin Soo Moon
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Pediatric-onset inflammatory bowel disease Colorectal cancer Crohn’s disease Ulcerative colitis Surveillance endoscopy Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/d8ca88bff4fd4d4d94e1a5c35a76bc36
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spelling	oai:doaj.org-article:d8ca88bff4fd4d4d94e1a5c35a76bc362021-11-14T12:33:29ZColorectal Cancer associated with pediatric inflammatory bowel disease: a case series10.1186/s12887-021-02966-91471-2431https://doaj.org/article/d8ca88bff4fd4d4d94e1a5c35a76bc362021-11-01T00:00:00Zhttps://doi.org/10.1186/s12887-021-02966-9https://doaj.org/toc/1471-2431Abstract Background Inflammatory bowel disease (IBD) is associated with an increased risk of Colorectal cancer (CRC), and its most important risk factors are the duration and extent of the disease. Pediatric-onset inflammatory bowel disease has a tendency for a more extensive, more severe, and longer predicted disease duration than adult-onset inflammatory bowel disease. This study aimed to identify the clinical characteristics of patients with CRC related to pediatric-onset IBD and consider the appropriateness of current surveillance endoscopy recommendations for the detection of premalignant lesions and early-stage CRC. Methods We searched a research platform based on the SUPREME electronic medical record data-mining system to identify cases of colorectal malignancy in patients with pediatric IBD that presented between 2000 and 2020. Results During the follow-up, 4 (1.29 per 1000 person years) out of 443 patients with PIBD was diagnosed with CRC. The median age at diagnosis of CRC was 18.5 (range: 15–24) years, and the median period from diagnosis of IBD to CRC was 9.42 (range: 0.44–11.96) years. The sigmoid colon was the most frequent location of CRC (in 3 of the 4 cases). Adenocarcinoma was the most common histological type (in 2 of the 4 cases). Conclusions Patients with pediatric-onset IBD exhibited a much shorter disease duration than that of adult-onset IBD at the time of diagnosis of CRC, suggesting that surveillance endoscopy for the detection of precancerous lesions and early-stage cancer should be initiated earlier in pediatric patients than in adult patients.Min Jee KimJae Sung KoMinsoo ShinJong Woo HahnSoo Young MoonHyun Young KimJin Soo MoonBMCarticlePediatric-onset inflammatory bowel diseaseColorectal cancerCrohn’s diseaseUlcerative colitisSurveillance endoscopyPediatricsRJ1-570ENBMC Pediatrics, Vol 21, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pediatric-onset inflammatory bowel disease Colorectal cancer Crohn’s disease Ulcerative colitis Surveillance endoscopy Pediatrics RJ1-570
spellingShingle	Pediatric-onset inflammatory bowel disease Colorectal cancer Crohn’s disease Ulcerative colitis Surveillance endoscopy Pediatrics RJ1-570 Min Jee Kim Jae Sung Ko Minsoo Shin Jong Woo Hahn Soo Young Moon Hyun Young Kim Jin Soo Moon Colorectal Cancer associated with pediatric inflammatory bowel disease: a case series
description	Abstract Background Inflammatory bowel disease (IBD) is associated with an increased risk of Colorectal cancer (CRC), and its most important risk factors are the duration and extent of the disease. Pediatric-onset inflammatory bowel disease has a tendency for a more extensive, more severe, and longer predicted disease duration than adult-onset inflammatory bowel disease. This study aimed to identify the clinical characteristics of patients with CRC related to pediatric-onset IBD and consider the appropriateness of current surveillance endoscopy recommendations for the detection of premalignant lesions and early-stage CRC. Methods We searched a research platform based on the SUPREME electronic medical record data-mining system to identify cases of colorectal malignancy in patients with pediatric IBD that presented between 2000 and 2020. Results During the follow-up, 4 (1.29 per 1000 person years) out of 443 patients with PIBD was diagnosed with CRC. The median age at diagnosis of CRC was 18.5 (range: 15–24) years, and the median period from diagnosis of IBD to CRC was 9.42 (range: 0.44–11.96) years. The sigmoid colon was the most frequent location of CRC (in 3 of the 4 cases). Adenocarcinoma was the most common histological type (in 2 of the 4 cases). Conclusions Patients with pediatric-onset IBD exhibited a much shorter disease duration than that of adult-onset IBD at the time of diagnosis of CRC, suggesting that surveillance endoscopy for the detection of precancerous lesions and early-stage cancer should be initiated earlier in pediatric patients than in adult patients.
format	article
author	Min Jee Kim Jae Sung Ko Minsoo Shin Jong Woo Hahn Soo Young Moon Hyun Young Kim Jin Soo Moon
author_facet	Min Jee Kim Jae Sung Ko Minsoo Shin Jong Woo Hahn Soo Young Moon Hyun Young Kim Jin Soo Moon
author_sort	Min Jee Kim
title	Colorectal Cancer associated with pediatric inflammatory bowel disease: a case series
title_short	Colorectal Cancer associated with pediatric inflammatory bowel disease: a case series
title_full	Colorectal Cancer associated with pediatric inflammatory bowel disease: a case series
title_fullStr	Colorectal Cancer associated with pediatric inflammatory bowel disease: a case series
title_full_unstemmed	Colorectal Cancer associated with pediatric inflammatory bowel disease: a case series
title_sort	colorectal cancer associated with pediatric inflammatory bowel disease: a case series
publisher	BMC
publishDate	2021
url	https://doaj.org/article/d8ca88bff4fd4d4d94e1a5c35a76bc36
work_keys_str_mv	AT minjeekim colorectalcancerassociatedwithpediatricinflammatoryboweldiseaseacaseseries AT jaesungko colorectalcancerassociatedwithpediatricinflammatoryboweldiseaseacaseseries AT minsooshin colorectalcancerassociatedwithpediatricinflammatoryboweldiseaseacaseseries AT jongwoohahn colorectalcancerassociatedwithpediatricinflammatoryboweldiseaseacaseseries AT sooyoungmoon colorectalcancerassociatedwithpediatricinflammatoryboweldiseaseacaseseries AT hyunyoungkim colorectalcancerassociatedwithpediatricinflammatoryboweldiseaseacaseseries AT jinsoomoon colorectalcancerassociatedwithpediatricinflammatoryboweldiseaseacaseseries
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Colorectal Cancer associated with pediatric inflammatory bowel disease: a case series

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