Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome

Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome

Antiphospholipid syndrome is characterised by increased neutrophil extracellular trap formation (NETosis) and, consequently, increased thrombotic events. Here Ali et al. show that treatment with adenosine receptor agonists suppresses NETosis and venous thrombosis in mouse models of antiphospholipid...

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Bibliographic Details
Main Authors: Ramadan A. Ali, Alex A. Gandhi, He Meng, Srilakshmi Yalavarthi, Andrew P. Vreede, Shanea K. Estes, Olivia R. Palmer, Paula L. Bockenstedt, David J. Pinsky, Joan M. Greve, Jose A. Diaz, Yogendra Kanthi, Jason S. Knight
Format: article
Language:EN
Published: Nature Portfolio 2019
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Science
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Online Access:https://doaj.org/article/d8ca98b7f1d54784a2dbed7642ccb42a
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Summary:Antiphospholipid syndrome is characterised by increased neutrophil extracellular trap formation (NETosis) and, consequently, increased thrombotic events. Here Ali et al. show that treatment with adenosine receptor agonists suppresses NETosis and venous thrombosis in mouse models of antiphospholipid syndrome.

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