Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome

Antiphospholipid syndrome is characterised by increased neutrophil extracellular trap formation (NETosis) and, consequently, increased thrombotic events. Here Ali et al. show that treatment with adenosine receptor agonists suppresses NETosis and venous thrombosis in mouse models of antiphospholipid...

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Auteurs principaux:	Ramadan A. Ali, Alex A. Gandhi, He Meng, Srilakshmi Yalavarthi, Andrew P. Vreede, Shanea K. Estes, Olivia R. Palmer, Paula L. Bockenstedt, David J. Pinsky, Joan M. Greve, Jose A. Diaz, Yogendra Kanthi, Jason S. Knight
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/d8ca98b7f1d54784a2dbed7642ccb42a
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spelling	oai:doaj.org-article:d8ca98b7f1d54784a2dbed7642ccb42a2021-12-02T14:38:40ZAdenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome10.1038/s41467-019-09801-x2041-1723https://doaj.org/article/d8ca98b7f1d54784a2dbed7642ccb42a2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09801-xhttps://doaj.org/toc/2041-1723Antiphospholipid syndrome is characterised by increased neutrophil extracellular trap formation (NETosis) and, consequently, increased thrombotic events. Here Ali et al. show that treatment with adenosine receptor agonists suppresses NETosis and venous thrombosis in mouse models of antiphospholipid syndrome.Ramadan A. AliAlex A. GandhiHe MengSrilakshmi YalavarthiAndrew P. VreedeShanea K. EstesOlivia R. PalmerPaula L. BockenstedtDavid J. PinskyJoan M. GreveJose A. DiazYogendra KanthiJason S. KnightNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ramadan A. Ali Alex A. Gandhi He Meng Srilakshmi Yalavarthi Andrew P. Vreede Shanea K. Estes Olivia R. Palmer Paula L. Bockenstedt David J. Pinsky Joan M. Greve Jose A. Diaz Yogendra Kanthi Jason S. Knight Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome
description	Antiphospholipid syndrome is characterised by increased neutrophil extracellular trap formation (NETosis) and, consequently, increased thrombotic events. Here Ali et al. show that treatment with adenosine receptor agonists suppresses NETosis and venous thrombosis in mouse models of antiphospholipid syndrome.
format	article
author	Ramadan A. Ali Alex A. Gandhi He Meng Srilakshmi Yalavarthi Andrew P. Vreede Shanea K. Estes Olivia R. Palmer Paula L. Bockenstedt David J. Pinsky Joan M. Greve Jose A. Diaz Yogendra Kanthi Jason S. Knight
author_facet	Ramadan A. Ali Alex A. Gandhi He Meng Srilakshmi Yalavarthi Andrew P. Vreede Shanea K. Estes Olivia R. Palmer Paula L. Bockenstedt David J. Pinsky Joan M. Greve Jose A. Diaz Yogendra Kanthi Jason S. Knight
author_sort	Ramadan A. Ali
title	Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome
title_short	Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome
title_full	Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome
title_fullStr	Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome
title_full_unstemmed	Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome
title_sort	adenosine receptor agonism protects against netosis and thrombosis in antiphospholipid syndrome
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d8ca98b7f1d54784a2dbed7642ccb42a
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Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome

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