Individualized Prediction Of Stroke-Associated Pneumonia For Patients With Acute Ischemic Stroke

Gui-Qian Huang,1,* Yu-Ting Lin,2,* Yue-Min Wu,1 Qian-Qian Cheng,3 Hao-Ran Cheng,1 Zhen Wang1 1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, People’s Republic of China; 2Department of Pulmonary Medicine, The First Affiliated...

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Autores principales:	Huang GQ, Lin YT, Wu YM, Cheng QQ, Cheng HR, Wang Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	stroke-associated pneumonia acute ischemic stroke nomogram prediction Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/d8cbc3f4758b434ea0cded1e0789c9a3
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spelling	oai:doaj.org-article:d8cbc3f4758b434ea0cded1e0789c9a32021-12-02T04:01:29ZIndividualized Prediction Of Stroke-Associated Pneumonia For Patients With Acute Ischemic Stroke1178-1998https://doaj.org/article/d8cbc3f4758b434ea0cded1e0789c9a32019-11-01T00:00:00Zhttps://www.dovepress.com/individualized-prediction-of-stroke-associated-pneumonia-for-patients--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Gui-Qian Huang,1,* Yu-Ting Lin,2,* Yue-Min Wu,1 Qian-Qian Cheng,3 Hao-Ran Cheng,1 Zhen Wang1 1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, People’s Republic of China; 2Department of Pulmonary Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, People’s Republic of China; 3School of Mental Health, Wenzhou Medical University, Wenzhou 325000, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhen WangDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, People’s Republic of ChinaTel +86 577-555780166Fax +86 577-55578033Email wangzhen_wenzhou@163.comBackground: Stroke-associated pneumonia (SAP) is a serious and common complication in stroke patients.Purpose: We aimed to develop and validate an easy-to-use model for predicting the risk of SAP in acute ischemic stroke (AIS) patients.Patients and methods: The nomogram was established by univariate and multivariate binary logistic analyses in a training cohort of 643 AIS patients. The prediction performance was determined based on the receiver operating characteristic curve (ROC) and calibration plots in a validation cohort (N=340). Individualized clinical decision-making was conducted by weighing the net benefit in each AIS patient by decision curve analysis (DCA).Results: Seven predictors, including age, NIHSS score on admission, atrial fibrillation, nasogastric tube intervention, mechanical ventilation, fibrinogen, and leukocyte count were incorporated to construct the nomogram model. The nomogram showed good predictive performance in ROC analysis [AUROC of 0.845 (95% CI: 0.814–0.872) in training cohort, and 0.897 (95% CI: 0.860–0.927) in validation cohort], and was superior to the A2DS2, ISAN, and PANTHERIS scores. Furthermore, the calibration plots showed good agreement between actual and nomogram-predicted SAP probabilities, in both training and validation cohorts. The DCA confirmed that the SAP nomogram was clinically useful.Conclusion: Our nomogram may provide clinicians with a simple and reliable tool for predicting SAP based on routinely available data. It may also assist clinicians with respect to individualized treatment decision-making for patients differing in risk level.Keywords: stroke-associated pneumonia, acute ischemic stroke, nomogram, predictionHuang GQLin YTWu YMCheng QQCheng HRWang ZDove Medical Pressarticlestroke-associated pneumoniaacute ischemic strokenomogrampredictionGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 1951-1962 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	stroke-associated pneumonia acute ischemic stroke nomogram prediction Geriatrics RC952-954.6
spellingShingle	stroke-associated pneumonia acute ischemic stroke nomogram prediction Geriatrics RC952-954.6 Huang GQ Lin YT Wu YM Cheng QQ Cheng HR Wang Z Individualized Prediction Of Stroke-Associated Pneumonia For Patients With Acute Ischemic Stroke
description	Gui-Qian Huang,1,* Yu-Ting Lin,2,* Yue-Min Wu,1 Qian-Qian Cheng,3 Hao-Ran Cheng,1 Zhen Wang1 1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, People’s Republic of China; 2Department of Pulmonary Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, People’s Republic of China; 3School of Mental Health, Wenzhou Medical University, Wenzhou 325000, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhen WangDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, People’s Republic of ChinaTel +86 577-555780166Fax +86 577-55578033Email wangzhen_wenzhou@163.comBackground: Stroke-associated pneumonia (SAP) is a serious and common complication in stroke patients.Purpose: We aimed to develop and validate an easy-to-use model for predicting the risk of SAP in acute ischemic stroke (AIS) patients.Patients and methods: The nomogram was established by univariate and multivariate binary logistic analyses in a training cohort of 643 AIS patients. The prediction performance was determined based on the receiver operating characteristic curve (ROC) and calibration plots in a validation cohort (N=340). Individualized clinical decision-making was conducted by weighing the net benefit in each AIS patient by decision curve analysis (DCA).Results: Seven predictors, including age, NIHSS score on admission, atrial fibrillation, nasogastric tube intervention, mechanical ventilation, fibrinogen, and leukocyte count were incorporated to construct the nomogram model. The nomogram showed good predictive performance in ROC analysis [AUROC of 0.845 (95% CI: 0.814–0.872) in training cohort, and 0.897 (95% CI: 0.860–0.927) in validation cohort], and was superior to the A2DS2, ISAN, and PANTHERIS scores. Furthermore, the calibration plots showed good agreement between actual and nomogram-predicted SAP probabilities, in both training and validation cohorts. The DCA confirmed that the SAP nomogram was clinically useful.Conclusion: Our nomogram may provide clinicians with a simple and reliable tool for predicting SAP based on routinely available data. It may also assist clinicians with respect to individualized treatment decision-making for patients differing in risk level.Keywords: stroke-associated pneumonia, acute ischemic stroke, nomogram, prediction
format	article
author	Huang GQ Lin YT Wu YM Cheng QQ Cheng HR Wang Z
author_facet	Huang GQ Lin YT Wu YM Cheng QQ Cheng HR Wang Z
author_sort	Huang GQ
title	Individualized Prediction Of Stroke-Associated Pneumonia For Patients With Acute Ischemic Stroke
title_short	Individualized Prediction Of Stroke-Associated Pneumonia For Patients With Acute Ischemic Stroke
title_full	Individualized Prediction Of Stroke-Associated Pneumonia For Patients With Acute Ischemic Stroke
title_fullStr	Individualized Prediction Of Stroke-Associated Pneumonia For Patients With Acute Ischemic Stroke
title_full_unstemmed	Individualized Prediction Of Stroke-Associated Pneumonia For Patients With Acute Ischemic Stroke
title_sort	individualized prediction of stroke-associated pneumonia for patients with acute ischemic stroke
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/d8cbc3f4758b434ea0cded1e0789c9a3
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Individualized Prediction Of Stroke-Associated Pneumonia For Patients With Acute Ischemic Stroke

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