Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis

Pulmonary alveolar proteinosis (PAP) is associated with defective macrophage clearance of surfactant. Here, the authors show that patients with PAP have altered cholesterol-to-phospholipid ratio in their surfactant, and that more importantly, statin therapy and reduction of cholesterol accumulation...

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Autores principales:	Cormac McCarthy, Elinor Lee, James P. Bridges, Anthony Sallese, Takuji Suzuki, Jason C. Woods, Brian J. Bartholmai, Tisha Wang, Claudia Chalk, Brenna C. Carey, Paritha Arumugam, Kenjiro Shima, Elizabeth J. Tarling, Bruce C. Trapnell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d8cc338509bd449f91fc403c8ee500b8
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spelling	oai:doaj.org-article:d8cc338509bd449f91fc403c8ee500b82021-12-02T14:39:25ZStatin as a novel pharmacotherapy of pulmonary alveolar proteinosis10.1038/s41467-018-05491-z2041-1723https://doaj.org/article/d8cc338509bd449f91fc403c8ee500b82018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05491-zhttps://doaj.org/toc/2041-1723Pulmonary alveolar proteinosis (PAP) is associated with defective macrophage clearance of surfactant. Here, the authors show that patients with PAP have altered cholesterol-to-phospholipid ratio in their surfactant, and that more importantly, statin therapy and reduction of cholesterol accumulation in macrophages can ameliorate PAP in both humans and mice.Cormac McCarthyElinor LeeJames P. BridgesAnthony SalleseTakuji SuzukiJason C. WoodsBrian J. BartholmaiTisha WangClaudia ChalkBrenna C. CareyParitha ArumugamKenjiro ShimaElizabeth J. TarlingBruce C. TrapnellNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cormac McCarthy Elinor Lee James P. Bridges Anthony Sallese Takuji Suzuki Jason C. Woods Brian J. Bartholmai Tisha Wang Claudia Chalk Brenna C. Carey Paritha Arumugam Kenjiro Shima Elizabeth J. Tarling Bruce C. Trapnell Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis
description	Pulmonary alveolar proteinosis (PAP) is associated with defective macrophage clearance of surfactant. Here, the authors show that patients with PAP have altered cholesterol-to-phospholipid ratio in their surfactant, and that more importantly, statin therapy and reduction of cholesterol accumulation in macrophages can ameliorate PAP in both humans and mice.
format	article
author	Cormac McCarthy Elinor Lee James P. Bridges Anthony Sallese Takuji Suzuki Jason C. Woods Brian J. Bartholmai Tisha Wang Claudia Chalk Brenna C. Carey Paritha Arumugam Kenjiro Shima Elizabeth J. Tarling Bruce C. Trapnell
author_facet	Cormac McCarthy Elinor Lee James P. Bridges Anthony Sallese Takuji Suzuki Jason C. Woods Brian J. Bartholmai Tisha Wang Claudia Chalk Brenna C. Carey Paritha Arumugam Kenjiro Shima Elizabeth J. Tarling Bruce C. Trapnell
author_sort	Cormac McCarthy
title	Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis
title_short	Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis
title_full	Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis
title_fullStr	Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis
title_full_unstemmed	Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis
title_sort	statin as a novel pharmacotherapy of pulmonary alveolar proteinosis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d8cc338509bd449f91fc403c8ee500b8
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_version_	1718390621602840576

Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis

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