Prefrontocerebellar transcranial direct current stimulation increases amplitude and decreases latency of P3b component in patients with euthymic bipolar disorder

Francesco Saverio Bersani, Amedeo Minichino, Francesco Fattapposta, Laura Bernabei, Francesco Spagnoli, Daniela Mannarelli, Marta Francesconi, Caterina Pauletti, Alessandra Corrado, Lucilla Vergnani, Ines Taddei, Massimo Biondi, Roberto Delle Chiaie Department of Neurology and Psychiatry, Sapienza...

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Autores principales:	Bersani FS, Minichino A, Fattapposta F, Bernabei L, Spagnoli F, Mannarelli D, Francesconi M, Pauletti C, Corrado A, Vergnani L, Taddei I, Biondi M, Delle Chiaie R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d8cdefe628ae408fb7c3b78d2a650fef
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spelling	oai:doaj.org-article:d8cdefe628ae408fb7c3b78d2a650fef2021-12-02T10:56:23ZPrefrontocerebellar transcranial direct current stimulation increases amplitude and decreases latency of P3b component in patients with euthymic bipolar disorder1178-2021https://doaj.org/article/d8cdefe628ae408fb7c3b78d2a650fef2015-11-01T00:00:00Zhttps://www.dovepress.com/prefrontocerebellar-transcranial-direct-current-stimulation-increases--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Francesco Saverio Bersani, Amedeo Minichino, Francesco Fattapposta, Laura Bernabei, Francesco Spagnoli, Daniela Mannarelli, Marta Francesconi, Caterina Pauletti, Alessandra Corrado, Lucilla Vergnani, Ines Taddei, Massimo Biondi, Roberto Delle Chiaie Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy Introduction: Neurocognitive impairments have been observed in patients with bipolar disorder (BD) even during the euthymic phase of the disease, potentially representing trait-associated rather than state-associated characteristics of the disorder. In the present study, we used transcranial direct current stimulation (tDCS) applied to cerebellar and prefrontal cortices to improve the neurophysiological performances of patients with euthymic BD.Methods: Twenty-five outpatients with BD underwent open-label prefrontocerebellar tDCS for 3 consecutive weeks. Neurophysiological performances were assessed through the examination of the P3b and P3a subcomponents of P300 event-related potential at baseline and after stimulation.Results: Compared to baseline, P3b component after tDCS showed significantly higher amplitude and shorter latency (latency: Fz P=0.02, Cz P=0.03, and Pz P=0.04; amplitude: Fz P=0.24, Cz P=0.02, and Pz P=0.35).Conclusion: In our sample of patients with euthymic BD, concomitant prefrontoexcitatory and cerebellar-inhibitory modulations led to improved brain information processing stream. This improvement may at least partially result from neuroplastic modulation of prefrontocerebellar circuitry activity. Keywords: mood disorders, tDCS, cerebellum, P300, dorsolateral prefrontal cortex, event-related potentialsBersani FSMinichino AFattapposta FBernabei LSpagnoli FMannarelli DFrancesconi MPauletti CCorrado AVergnani LTaddei IBiondi MDelle Chiaie RDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 2913-2917 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Bersani FS Minichino A Fattapposta F Bernabei L Spagnoli F Mannarelli D Francesconi M Pauletti C Corrado A Vergnani L Taddei I Biondi M Delle Chiaie R Prefrontocerebellar transcranial direct current stimulation increases amplitude and decreases latency of P3b component in patients with euthymic bipolar disorder
description	Francesco Saverio Bersani, Amedeo Minichino, Francesco Fattapposta, Laura Bernabei, Francesco Spagnoli, Daniela Mannarelli, Marta Francesconi, Caterina Pauletti, Alessandra Corrado, Lucilla Vergnani, Ines Taddei, Massimo Biondi, Roberto Delle Chiaie Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy Introduction: Neurocognitive impairments have been observed in patients with bipolar disorder (BD) even during the euthymic phase of the disease, potentially representing trait-associated rather than state-associated characteristics of the disorder. In the present study, we used transcranial direct current stimulation (tDCS) applied to cerebellar and prefrontal cortices to improve the neurophysiological performances of patients with euthymic BD.Methods: Twenty-five outpatients with BD underwent open-label prefrontocerebellar tDCS for 3 consecutive weeks. Neurophysiological performances were assessed through the examination of the P3b and P3a subcomponents of P300 event-related potential at baseline and after stimulation.Results: Compared to baseline, P3b component after tDCS showed significantly higher amplitude and shorter latency (latency: Fz P=0.02, Cz P=0.03, and Pz P=0.04; amplitude: Fz P=0.24, Cz P=0.02, and Pz P=0.35).Conclusion: In our sample of patients with euthymic BD, concomitant prefrontoexcitatory and cerebellar-inhibitory modulations led to improved brain information processing stream. This improvement may at least partially result from neuroplastic modulation of prefrontocerebellar circuitry activity. Keywords: mood disorders, tDCS, cerebellum, P300, dorsolateral prefrontal cortex, event-related potentials
format	article
author	Bersani FS Minichino A Fattapposta F Bernabei L Spagnoli F Mannarelli D Francesconi M Pauletti C Corrado A Vergnani L Taddei I Biondi M Delle Chiaie R
author_facet	Bersani FS Minichino A Fattapposta F Bernabei L Spagnoli F Mannarelli D Francesconi M Pauletti C Corrado A Vergnani L Taddei I Biondi M Delle Chiaie R
author_sort	Bersani FS
title	Prefrontocerebellar transcranial direct current stimulation increases amplitude and decreases latency of P3b component in patients with euthymic bipolar disorder
title_short	Prefrontocerebellar transcranial direct current stimulation increases amplitude and decreases latency of P3b component in patients with euthymic bipolar disorder
title_full	Prefrontocerebellar transcranial direct current stimulation increases amplitude and decreases latency of P3b component in patients with euthymic bipolar disorder
title_fullStr	Prefrontocerebellar transcranial direct current stimulation increases amplitude and decreases latency of P3b component in patients with euthymic bipolar disorder
title_full_unstemmed	Prefrontocerebellar transcranial direct current stimulation increases amplitude and decreases latency of P3b component in patients with euthymic bipolar disorder
title_sort	prefrontocerebellar transcranial direct current stimulation increases amplitude and decreases latency of p3b component in patients with euthymic bipolar disorder
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/d8cdefe628ae408fb7c3b78d2a650fef
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Prefrontocerebellar transcranial direct current stimulation increases amplitude and decreases latency of P3b component in patients with euthymic bipolar disorder

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