Mechanism of RNA polymerase III termination-associated reinitiation-recycling conferred by the essential function of the N terminal-and-linker domain of the C11 subunit

RNA polymerase III (Pol III) employs termination-associated reinitiation-recycling to express high amounts of tRNAs, which involves the essential C11 subunit. Here the authors determine the functions of various C11 domains, finding that the N-terminal domain (NTD) stimulates termination, reinitiatio...

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Autores principales:	Saurabh Mishra, Shaina H. Hasan, Rima M. Sakhawala, Shereen Chaudhry, Richard J. Maraia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d8cf6ad2d84848129d410b1e12371186
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spelling	oai:doaj.org-article:d8cf6ad2d84848129d410b1e123711862021-12-02T18:01:42ZMechanism of RNA polymerase III termination-associated reinitiation-recycling conferred by the essential function of the N terminal-and-linker domain of the C11 subunit10.1038/s41467-021-26080-72041-1723https://doaj.org/article/d8cf6ad2d84848129d410b1e123711862021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26080-7https://doaj.org/toc/2041-1723RNA polymerase III (Pol III) employs termination-associated reinitiation-recycling to express high amounts of tRNAs, which involves the essential C11 subunit. Here the authors determine the functions of various C11 domains, finding that the N-terminal domain (NTD) stimulates termination, reinitiation-recycling requires an NTD-linker, and the C-terminal domain stimulates RNA 3′-cleavage.Saurabh MishraShaina H. HasanRima M. SakhawalaShereen ChaudhryRichard J. MaraiaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Saurabh Mishra Shaina H. Hasan Rima M. Sakhawala Shereen Chaudhry Richard J. Maraia Mechanism of RNA polymerase III termination-associated reinitiation-recycling conferred by the essential function of the N terminal-and-linker domain of the C11 subunit
description	RNA polymerase III (Pol III) employs termination-associated reinitiation-recycling to express high amounts of tRNAs, which involves the essential C11 subunit. Here the authors determine the functions of various C11 domains, finding that the N-terminal domain (NTD) stimulates termination, reinitiation-recycling requires an NTD-linker, and the C-terminal domain stimulates RNA 3′-cleavage.
format	article
author	Saurabh Mishra Shaina H. Hasan Rima M. Sakhawala Shereen Chaudhry Richard J. Maraia
author_facet	Saurabh Mishra Shaina H. Hasan Rima M. Sakhawala Shereen Chaudhry Richard J. Maraia
author_sort	Saurabh Mishra
title	Mechanism of RNA polymerase III termination-associated reinitiation-recycling conferred by the essential function of the N terminal-and-linker domain of the C11 subunit
title_short	Mechanism of RNA polymerase III termination-associated reinitiation-recycling conferred by the essential function of the N terminal-and-linker domain of the C11 subunit
title_full	Mechanism of RNA polymerase III termination-associated reinitiation-recycling conferred by the essential function of the N terminal-and-linker domain of the C11 subunit
title_fullStr	Mechanism of RNA polymerase III termination-associated reinitiation-recycling conferred by the essential function of the N terminal-and-linker domain of the C11 subunit
title_full_unstemmed	Mechanism of RNA polymerase III termination-associated reinitiation-recycling conferred by the essential function of the N terminal-and-linker domain of the C11 subunit
title_sort	mechanism of rna polymerase iii termination-associated reinitiation-recycling conferred by the essential function of the n terminal-and-linker domain of the c11 subunit
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d8cf6ad2d84848129d410b1e12371186
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Mechanism of RNA polymerase III termination-associated reinitiation-recycling conferred by the essential function of the N terminal-and-linker domain of the C11 subunit

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