PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery

The anti-diabetic drug Metformin also possesses anti-tumour activity. Here, the authors synthesize polymeric Metformin-based nanoparticles that still exert intrinsic biological activity through AMPK and mTOR regulation and can systematically deliver VEGF siRNA, significantly reducing lung cancer gro...

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Autores principales:	Yi Zhao, Wei Wang, Shutao Guo, Yuhua Wang, Lei Miao, Yang Xiong, Leaf Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d8d0188e952a4aed809eebe69a78701e
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spelling	oai:doaj.org-article:d8d0188e952a4aed809eebe69a78701e2021-12-02T16:57:01ZPolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery10.1038/ncomms118222041-1723https://doaj.org/article/d8d0188e952a4aed809eebe69a78701e2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11822https://doaj.org/toc/2041-1723The anti-diabetic drug Metformin also possesses anti-tumour activity. Here, the authors synthesize polymeric Metformin-based nanoparticles that still exert intrinsic biological activity through AMPK and mTOR regulation and can systematically deliver VEGF siRNA, significantly reducing lung cancer growth in mice.Yi ZhaoWei WangShutao GuoYuhua WangLei MiaoYang XiongLeaf HuangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yi Zhao Wei Wang Shutao Guo Yuhua Wang Lei Miao Yang Xiong Leaf Huang PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery
description	The anti-diabetic drug Metformin also possesses anti-tumour activity. Here, the authors synthesize polymeric Metformin-based nanoparticles that still exert intrinsic biological activity through AMPK and mTOR regulation and can systematically deliver VEGF siRNA, significantly reducing lung cancer growth in mice.
format	article
author	Yi Zhao Wei Wang Shutao Guo Yuhua Wang Lei Miao Yang Xiong Leaf Huang
author_facet	Yi Zhao Wei Wang Shutao Guo Yuhua Wang Lei Miao Yang Xiong Leaf Huang
author_sort	Yi Zhao
title	PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery
title_short	PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery
title_full	PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery
title_fullStr	PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery
title_full_unstemmed	PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery
title_sort	polymetformin combines carrier and anticancer activities for in vivo sirna delivery
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d8d0188e952a4aed809eebe69a78701e
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PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery

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