Loss of Asxl2 leads to myeloid malignancies in mice

ASXL2 mutations are mostly found in a subset of leukemia patients with certain genetic aberrations; however the role of this protein in normal hematopoiesis and related malignancies is still unclear. Here the authors use a knock-out mouse model to uncover the role of Asxl2in hematopoiesis and leukem...

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Autores principales:	Jianping Li, Fuhong He, Peng Zhang, Shi Chen, Hui Shi, Yanling Sun, Ying Guo, Hui Yang, Na Man, Sarah Greenblatt, Zhaomin Li, Zhengyu Guo, Yuan Zhou, Lan Wang, Lluis Morey, Sion Williams, Xi Chen, Qun-Tian Wang, Stephen D. Nimer, Peng Yu, Qian-Fei Wang, Mingjiang Xu, Feng-Chun Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d8d0621e6a8f4b58bd9d7e748569e036
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spelling	oai:doaj.org-article:d8d0621e6a8f4b58bd9d7e748569e0362021-12-02T15:38:56ZLoss of Asxl2 leads to myeloid malignancies in mice10.1038/ncomms154562041-1723https://doaj.org/article/d8d0621e6a8f4b58bd9d7e748569e0362017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15456https://doaj.org/toc/2041-1723ASXL2 mutations are mostly found in a subset of leukemia patients with certain genetic aberrations; however the role of this protein in normal hematopoiesis and related malignancies is still unclear. Here the authors use a knock-out mouse model to uncover the role of Asxl2in hematopoiesis and leukemogenesis.Jianping LiFuhong HePeng ZhangShi ChenHui ShiYanling SunYing GuoHui YangNa ManSarah GreenblattZhaomin LiZhengyu GuoYuan ZhouLan WangLluis MoreySion WilliamsXi ChenQun-Tian WangStephen D. NimerPeng YuQian-Fei WangMingjiang XuFeng-Chun YangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jianping Li Fuhong He Peng Zhang Shi Chen Hui Shi Yanling Sun Ying Guo Hui Yang Na Man Sarah Greenblatt Zhaomin Li Zhengyu Guo Yuan Zhou Lan Wang Lluis Morey Sion Williams Xi Chen Qun-Tian Wang Stephen D. Nimer Peng Yu Qian-Fei Wang Mingjiang Xu Feng-Chun Yang Loss of Asxl2 leads to myeloid malignancies in mice
description	ASXL2 mutations are mostly found in a subset of leukemia patients with certain genetic aberrations; however the role of this protein in normal hematopoiesis and related malignancies is still unclear. Here the authors use a knock-out mouse model to uncover the role of Asxl2in hematopoiesis and leukemogenesis.
format	article
author	Jianping Li Fuhong He Peng Zhang Shi Chen Hui Shi Yanling Sun Ying Guo Hui Yang Na Man Sarah Greenblatt Zhaomin Li Zhengyu Guo Yuan Zhou Lan Wang Lluis Morey Sion Williams Xi Chen Qun-Tian Wang Stephen D. Nimer Peng Yu Qian-Fei Wang Mingjiang Xu Feng-Chun Yang
author_facet	Jianping Li Fuhong He Peng Zhang Shi Chen Hui Shi Yanling Sun Ying Guo Hui Yang Na Man Sarah Greenblatt Zhaomin Li Zhengyu Guo Yuan Zhou Lan Wang Lluis Morey Sion Williams Xi Chen Qun-Tian Wang Stephen D. Nimer Peng Yu Qian-Fei Wang Mingjiang Xu Feng-Chun Yang
author_sort	Jianping Li
title	Loss of Asxl2 leads to myeloid malignancies in mice
title_short	Loss of Asxl2 leads to myeloid malignancies in mice
title_full	Loss of Asxl2 leads to myeloid malignancies in mice
title_fullStr	Loss of Asxl2 leads to myeloid malignancies in mice
title_full_unstemmed	Loss of Asxl2 leads to myeloid malignancies in mice
title_sort	loss of asxl2 leads to myeloid malignancies in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d8d0621e6a8f4b58bd9d7e748569e036
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Loss of Asxl2 leads to myeloid malignancies in mice

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