CYTOTOXICITY AND ANTICARCINOGENIC ACTIVITY OF TWO FLAVONOIDS ISOLATED AND PURIFIED FROM <I>Brownea ariza Brenth</I>
The growing resistance to anticancer agents has turned medical science and pharmacology towards finding new compounds with these characteristics; in this area the natural products have great relevance, since many of these have anticancer activity. Flavonoids as secondary metabolites have reported an...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Universidad de Antioquia
2009
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/d8d88c5424f2489abc34385a507d2d55 |
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| Sumario: | The growing resistance to anticancer agents has turned medical science and pharmacology towards finding
new compounds with these characteristics; in this area the natural products have great relevance, since
many of these have anticancer activity. Flavonoids as secondary metabolites have reported anti-tumor
activity and can become important source for cancer treatment; why search isolate flavonoids Brownea
ariza Brenth to evaluate their anticancer activity. The Phytochemical analysis of leaves of Brownea ariza
Brenth. (Caesalpiniaceae) let isolate a flavonol identified as (1), and a glycoside flavonol described as
Quercitrin (2). The structures are determined by spectroscopic techniques: UV-Vis with shift reagents; 1D and 2D NMR (1H, 13C, COSY, DEPT, HMBC; HMQC), and mass spectrometry. It evaluates the
cytotoxic activity in VERO cell (ATCC: CCL-81) and anticancer activity in Myeloma Murino SP2/0-Ag14
(ATCC: CRL-1581), doing count the number of viable cells by graduation with tripan blue, obtaining a
concentration cytotoxic average (1) of 300 μg/mL and not determined to (2) in concentrations of work;
anticancer activity for (1) has a median effective concentration of 150 μg /mL and not given to (2) in
concentrations of work.
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