CYTOTOXICITY AND ANTICARCINOGENIC ACTIVITY OF TWO FLAVONOIDS ISOLATED AND PURIFIED FROM <I>Brownea ariza Brenth</I>
The growing resistance to anticancer agents has turned medical science and pharmacology towards finding new compounds with these characteristics; in this area the natural products have great relevance, since many of these have anticancer activity. Flavonoids as secondary metabolites have reported an...
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Universidad de Antioquia
2009
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oai:doaj.org-article:d8d88c5424f2489abc34385a507d2d552021-11-19T04:16:22ZCYTOTOXICITY AND ANTICARCINOGENIC ACTIVITY OF TWO FLAVONOIDS ISOLATED AND PURIFIED FROM <I>Brownea ariza Brenth</I>0121-40042145-2660https://doaj.org/article/d8d88c5424f2489abc34385a507d2d552009-05-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/1430https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660The growing resistance to anticancer agents has turned medical science and pharmacology towards finding new compounds with these characteristics; in this area the natural products have great relevance, since many of these have anticancer activity. Flavonoids as secondary metabolites have reported anti-tumor activity and can become important source for cancer treatment; why search isolate flavonoids Brownea ariza Brenth to evaluate their anticancer activity. The Phytochemical analysis of leaves of Brownea ariza Brenth. (Caesalpiniaceae) let isolate a flavonol identified as (1), and a glycoside flavonol described as Quercitrin (2). The structures are determined by spectroscopic techniques: UV-Vis with shift reagents; 1D and 2D NMR (1H, 13C, COSY, DEPT, HMBC; HMQC), and mass spectrometry. It evaluates the cytotoxic activity in VERO cell (ATCC: CCL-81) and anticancer activity in Myeloma Murino SP2/0-Ag14 (ATCC: CRL-1581), doing count the number of viable cells by graduation with tripan blue, obtaining a concentration cytotoxic average (1) of 300 μg/mL and not determined to (2) in concentrations of work; anticancer activity for (1) has a median effective concentration of 150 μg /mL and not given to (2) in concentrations of work. Juan F. GIL R.Milton GÓMEZ B.Juanita TREJOS S.Universidad de Antioquiaarticleisolationpurificationflavonoidscytotoxicityanti-cancer agentsBrownea ariza.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 16, Iss 1 (2009) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
isolation purification flavonoids cytotoxicity anti-cancer agents Brownea ariza. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 |
| spellingShingle |
isolation purification flavonoids cytotoxicity anti-cancer agents Brownea ariza. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Juan F. GIL R. Milton GÓMEZ B. Juanita TREJOS S. CYTOTOXICITY AND ANTICARCINOGENIC ACTIVITY OF TWO FLAVONOIDS ISOLATED AND PURIFIED FROM <I>Brownea ariza Brenth</I> |
| description |
The growing resistance to anticancer agents has turned medical science and pharmacology towards finding
new compounds with these characteristics; in this area the natural products have great relevance, since
many of these have anticancer activity. Flavonoids as secondary metabolites have reported anti-tumor
activity and can become important source for cancer treatment; why search isolate flavonoids Brownea
ariza Brenth to evaluate their anticancer activity. The Phytochemical analysis of leaves of Brownea ariza
Brenth. (Caesalpiniaceae) let isolate a flavonol identified as (1), and a glycoside flavonol described as
Quercitrin (2). The structures are determined by spectroscopic techniques: UV-Vis with shift reagents; 1D and 2D NMR (1H, 13C, COSY, DEPT, HMBC; HMQC), and mass spectrometry. It evaluates the
cytotoxic activity in VERO cell (ATCC: CCL-81) and anticancer activity in Myeloma Murino SP2/0-Ag14
(ATCC: CRL-1581), doing count the number of viable cells by graduation with tripan blue, obtaining a
concentration cytotoxic average (1) of 300 μg/mL and not determined to (2) in concentrations of work;
anticancer activity for (1) has a median effective concentration of 150 μg /mL and not given to (2) in
concentrations of work.
|
| format |
article |
| author |
Juan F. GIL R. Milton GÓMEZ B. Juanita TREJOS S. |
| author_facet |
Juan F. GIL R. Milton GÓMEZ B. Juanita TREJOS S. |
| author_sort |
Juan F. GIL R. |
| title |
CYTOTOXICITY AND ANTICARCINOGENIC ACTIVITY OF TWO FLAVONOIDS ISOLATED AND PURIFIED FROM <I>Brownea ariza Brenth</I> |
| title_short |
CYTOTOXICITY AND ANTICARCINOGENIC ACTIVITY OF TWO FLAVONOIDS ISOLATED AND PURIFIED FROM <I>Brownea ariza Brenth</I> |
| title_full |
CYTOTOXICITY AND ANTICARCINOGENIC ACTIVITY OF TWO FLAVONOIDS ISOLATED AND PURIFIED FROM <I>Brownea ariza Brenth</I> |
| title_fullStr |
CYTOTOXICITY AND ANTICARCINOGENIC ACTIVITY OF TWO FLAVONOIDS ISOLATED AND PURIFIED FROM <I>Brownea ariza Brenth</I> |
| title_full_unstemmed |
CYTOTOXICITY AND ANTICARCINOGENIC ACTIVITY OF TWO FLAVONOIDS ISOLATED AND PURIFIED FROM <I>Brownea ariza Brenth</I> |
| title_sort |
cytotoxicity and anticarcinogenic activity of two flavonoids isolated and purified from <i>brownea ariza brenth</i> |
| publisher |
Universidad de Antioquia |
| publishDate |
2009 |
| url |
https://doaj.org/article/d8d88c5424f2489abc34385a507d2d55 |
| work_keys_str_mv |
AT juanfgilr cytotoxicityandanticarcinogenicactivityoftwoflavonoidsisolatedandpurifiedfromibrowneaarizabrenthi AT miltongomezb cytotoxicityandanticarcinogenicactivityoftwoflavonoidsisolatedandpurifiedfromibrowneaarizabrenthi AT juanitatrejoss cytotoxicityandanticarcinogenicactivityoftwoflavonoidsisolatedandpurifiedfromibrowneaarizabrenthi |
| _version_ |
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