Nrac, a novel nutritionally-regulated adipose and cardiac-enriched gene.

Obesity increases the risk of multiple diseases, such as type 2 diabetes and coronary heart diseases, and therefore the current obesity epidemic poses a major public health issue. Therapeutic approaches are urgently needed to treat obesity as well as its complications. Plasma-membrane proteins with...

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Autores principales:	Ren Zhang, Fayi Yao, Feng Gao, Abdul B Abou-Samra
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d8db738c4c7446e9b1e1b48fdcb66c9e
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spelling	oai:doaj.org-article:d8db738c4c7446e9b1e1b48fdcb66c9e2021-11-18T08:13:47ZNrac, a novel nutritionally-regulated adipose and cardiac-enriched gene.1932-620310.1371/journal.pone.0046254https://doaj.org/article/d8db738c4c7446e9b1e1b48fdcb66c9e2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23029450/?tool=EBIhttps://doaj.org/toc/1932-6203Obesity increases the risk of multiple diseases, such as type 2 diabetes and coronary heart diseases, and therefore the current obesity epidemic poses a major public health issue. Therapeutic approaches are urgently needed to treat obesity as well as its complications. Plasma-membrane proteins with restricted tissue distributions are attractive drug targets, because of their accessibility to various drug delivery mechanisms and potentially alleviated side effects. To identify genes involved in metabolism, we performed RNA-Seq on fat in mice treated with a high-fat diet or fasting. Here we show that the gene A530016L24Rik (human ortholog C14orf180), named Nrac, is a novel nutritionally-regulated adipose and cardiac-enriched gene. Nrac is expressed specifically and abundantly in fat and the heart. Both fasting and obesity reduced Nrac expression in white adipose tissue, and fasting reduced its expression in brown fat. Nrac is localized to the plasma membrane, and highly induced during adipocyte differentiation. Nrac is therefore a novel adipocyte marker and has potential functions in metabolism.Ren ZhangFayi YaoFeng GaoAbdul B Abou-SamraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e46254 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ren Zhang Fayi Yao Feng Gao Abdul B Abou-Samra Nrac, a novel nutritionally-regulated adipose and cardiac-enriched gene.
description	Obesity increases the risk of multiple diseases, such as type 2 diabetes and coronary heart diseases, and therefore the current obesity epidemic poses a major public health issue. Therapeutic approaches are urgently needed to treat obesity as well as its complications. Plasma-membrane proteins with restricted tissue distributions are attractive drug targets, because of their accessibility to various drug delivery mechanisms and potentially alleviated side effects. To identify genes involved in metabolism, we performed RNA-Seq on fat in mice treated with a high-fat diet or fasting. Here we show that the gene A530016L24Rik (human ortholog C14orf180), named Nrac, is a novel nutritionally-regulated adipose and cardiac-enriched gene. Nrac is expressed specifically and abundantly in fat and the heart. Both fasting and obesity reduced Nrac expression in white adipose tissue, and fasting reduced its expression in brown fat. Nrac is localized to the plasma membrane, and highly induced during adipocyte differentiation. Nrac is therefore a novel adipocyte marker and has potential functions in metabolism.
format	article
author	Ren Zhang Fayi Yao Feng Gao Abdul B Abou-Samra
author_facet	Ren Zhang Fayi Yao Feng Gao Abdul B Abou-Samra
author_sort	Ren Zhang
title	Nrac, a novel nutritionally-regulated adipose and cardiac-enriched gene.
title_short	Nrac, a novel nutritionally-regulated adipose and cardiac-enriched gene.
title_full	Nrac, a novel nutritionally-regulated adipose and cardiac-enriched gene.
title_fullStr	Nrac, a novel nutritionally-regulated adipose and cardiac-enriched gene.
title_full_unstemmed	Nrac, a novel nutritionally-regulated adipose and cardiac-enriched gene.
title_sort	nrac, a novel nutritionally-regulated adipose and cardiac-enriched gene.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/d8db738c4c7446e9b1e1b48fdcb66c9e
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Nrac, a novel nutritionally-regulated adipose and cardiac-enriched gene.

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