Constitutive activation of NF-κB inducing kinase (NIK) in the mesenchymal lineage using Osterix (Sp7)- or Fibroblast-specific protein 1 (S100a4)-Cre drives spontaneous soft tissue sarcoma.

Constitutive activation of NF-κB inducing kinase (NIK) in the mesenchymal lineage using Osterix (Sp7)- or Fibroblast-specific protein 1 (S100a4)-Cre drives spontaneous soft tissue sarcoma.

Aberrant NF-κB signaling fuels tumor growth in multiple human cancer types including both hematologic and solid malignancies. Chronic elevated alternative NF-κB signaling can be modeled in transgenic mice upon activation of a conditional NF-κB-inducing kinase (NIK) allele lacking the regulatory TRAF...

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Bibliographic Details
Main Authors: Jennifer L Davis, Roman Thaler, Linda Cox, Biancamaria Ricci, Heather M Zannit, Fei Wan, Roberta Faccio, Amel Dudakovic, Andre J van Wijnen, Deborah J Veis
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2021
Subjects:
Medicine
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Science
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Online Access:https://doaj.org/article/d8db811e861d4f609a79355033e728a4
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https://doaj.org/article/d8db811e861d4f609a79355033e728a4

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