Angiogenesis Biomarkers in Ischemic Stroke Patients

Aziza Alrafiah,1 Ebtisam Alofi,2 Yasser Almohaya,1 Abdullah Hamami,1 Talal Qadah,1 Safa Almaghrabi,2 Nora Hakami,1 Moafaq S Alrawaili,3 Haythum O Tayeb3 1Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of...

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Autores principales:	Alrafiah A, Alofi E, Almohaya Y, Hamami A, Qadah T, Almaghrabi S, Hakami N, Alrawaili MS, Tayeb HO
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	stroke angiopoietin biomarkers angiopoietin endoglin endothelin-1 and vegf-a Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/d8dc33ffe073483e9a0b02530e4afb91
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spelling	oai:doaj.org-article:d8dc33ffe073483e9a0b02530e4afb912021-12-02T17:40:32ZAngiogenesis Biomarkers in Ischemic Stroke Patients1178-7031https://doaj.org/article/d8dc33ffe073483e9a0b02530e4afb912021-09-01T00:00:00Zhttps://www.dovepress.com/angiogenesis-biomarkers-in-ischemic-stroke-patients-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Aziza Alrafiah,1 Ebtisam Alofi,2 Yasser Almohaya,1 Abdullah Hamami,1 Talal Qadah,1 Safa Almaghrabi,2 Nora Hakami,1 Moafaq S Alrawaili,3 Haythum O Tayeb3 1Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Physiology, Medical School, King Abdulaziz University, Jeddah, Saudi Arabia; 3Division of Neurology, Department of Internal Medicine, Faculty of Medicine, King AbdulAziz University, Jeddah, Saudi ArabiaCorrespondence: Aziza Alrafiah Tel +966 0126401000 Ext. 23495Email aalrafiah@kau.edu.saIntroduction: Stroke is a global health issue, and ischemic stroke is among the most common strokes affecting many people worldwide. Throughout ischemic stroke, various immune cells counter its effect by releasing cytokines, chemokines, and angiogenic molecules. These molecules can work as potential biomarkers in the diagnosis and monitoring of the progress of ischemic stroke. The current study investigated the use of angiogenic molecules as biomarkers in ischemic stroke patients.Methods: The samples were obtained from twenty healthy subjects and nineteen patients with ischemic stroke. Multiplex assay was used to measure the serum levels of angiogenic biomarkers, including endoglin, VEGF-A, endothelin-1, G-CSF, and angiopoietin-2. All data were analyzed using an unpaired Student’s t-test. Correlations between measured parameters were made using Pearson correlations.Results: Angiopoietin-2, VEGF-A, endothelin-1, and endoglin levels in stroke patients were significantly higher compared to healthy controls. Nevertheless, G-CSF level showed a non-significant increase in patients compared to controls. The correlation coefficient of measured angiogenic biomarkers among patients showed significant correlations between endoglin, angiopoietin, VEGF-A, and endothelin-1.Discussion: The angiogenic factors were significantly increased in patients with ischemic stroke, which may help in the early detection of ischemic stroke and consequently prompt treatment and better prognosis.Keywords: stroke, angiopoietin biomarkers, angiopoietin, endoglin, endothelin-1, VEGF-AAlrafiah AAlofi EAlmohaya YHamami AQadah TAlmaghrabi SHakami NAlrawaili MSTayeb HODove Medical Pressarticlestrokeangiopoietin biomarkersangiopoietinendoglinendothelin-1and vegf-aPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 4893-4900 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stroke angiopoietin biomarkers angiopoietin endoglin endothelin-1 and vegf-a Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	stroke angiopoietin biomarkers angiopoietin endoglin endothelin-1 and vegf-a Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Alrafiah A Alofi E Almohaya Y Hamami A Qadah T Almaghrabi S Hakami N Alrawaili MS Tayeb HO Angiogenesis Biomarkers in Ischemic Stroke Patients
description	Aziza Alrafiah,1 Ebtisam Alofi,2 Yasser Almohaya,1 Abdullah Hamami,1 Talal Qadah,1 Safa Almaghrabi,2 Nora Hakami,1 Moafaq S Alrawaili,3 Haythum O Tayeb3 1Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Physiology, Medical School, King Abdulaziz University, Jeddah, Saudi Arabia; 3Division of Neurology, Department of Internal Medicine, Faculty of Medicine, King AbdulAziz University, Jeddah, Saudi ArabiaCorrespondence: Aziza Alrafiah Tel +966 0126401000 Ext. 23495Email aalrafiah@kau.edu.saIntroduction: Stroke is a global health issue, and ischemic stroke is among the most common strokes affecting many people worldwide. Throughout ischemic stroke, various immune cells counter its effect by releasing cytokines, chemokines, and angiogenic molecules. These molecules can work as potential biomarkers in the diagnosis and monitoring of the progress of ischemic stroke. The current study investigated the use of angiogenic molecules as biomarkers in ischemic stroke patients.Methods: The samples were obtained from twenty healthy subjects and nineteen patients with ischemic stroke. Multiplex assay was used to measure the serum levels of angiogenic biomarkers, including endoglin, VEGF-A, endothelin-1, G-CSF, and angiopoietin-2. All data were analyzed using an unpaired Student’s t-test. Correlations between measured parameters were made using Pearson correlations.Results: Angiopoietin-2, VEGF-A, endothelin-1, and endoglin levels in stroke patients were significantly higher compared to healthy controls. Nevertheless, G-CSF level showed a non-significant increase in patients compared to controls. The correlation coefficient of measured angiogenic biomarkers among patients showed significant correlations between endoglin, angiopoietin, VEGF-A, and endothelin-1.Discussion: The angiogenic factors were significantly increased in patients with ischemic stroke, which may help in the early detection of ischemic stroke and consequently prompt treatment and better prognosis.Keywords: stroke, angiopoietin biomarkers, angiopoietin, endoglin, endothelin-1, VEGF-A
format	article
author	Alrafiah A Alofi E Almohaya Y Hamami A Qadah T Almaghrabi S Hakami N Alrawaili MS Tayeb HO
author_facet	Alrafiah A Alofi E Almohaya Y Hamami A Qadah T Almaghrabi S Hakami N Alrawaili MS Tayeb HO
author_sort	Alrafiah A
title	Angiogenesis Biomarkers in Ischemic Stroke Patients
title_short	Angiogenesis Biomarkers in Ischemic Stroke Patients
title_full	Angiogenesis Biomarkers in Ischemic Stroke Patients
title_fullStr	Angiogenesis Biomarkers in Ischemic Stroke Patients
title_full_unstemmed	Angiogenesis Biomarkers in Ischemic Stroke Patients
title_sort	angiogenesis biomarkers in ischemic stroke patients
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/d8dc33ffe073483e9a0b02530e4afb91
work_keys_str_mv	AT alrafiaha angiogenesisbiomarkersinischemicstrokepatients AT alofie angiogenesisbiomarkersinischemicstrokepatients AT almohayay angiogenesisbiomarkersinischemicstrokepatients AT hamamia angiogenesisbiomarkersinischemicstrokepatients AT qadaht angiogenesisbiomarkersinischemicstrokepatients AT almaghrabis angiogenesisbiomarkersinischemicstrokepatients AT hakamin angiogenesisbiomarkersinischemicstrokepatients AT alrawailims angiogenesisbiomarkersinischemicstrokepatients AT tayebho angiogenesisbiomarkersinischemicstrokepatients
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Angiogenesis Biomarkers in Ischemic Stroke Patients

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