The Gene Ontology's Reference Genome Project: a unified framework for functional annotation across species.

The Gene Ontology (GO) is a collaborative effort that provides structured vocabularies for annotating the molecular function, biological role, and cellular location of gene products in a highly systematic way and in a species-neutral manner with the aim of unifying the representation of gene functio...

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Main Author:	Reference Genome Group of the Gene Ontology Consortium
Format:	article
Language:	EN
Published:	Public Library of Science (PLoS) 2009
Subjects:	Biology (General) QH301-705.5
Online Access:	https://doaj.org/article/d8dd6b33a0b04a27b0bcb6ee2430aec1
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id	oai:doaj.org-article:d8dd6b33a0b04a27b0bcb6ee2430aec1
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spelling	oai:doaj.org-article:d8dd6b33a0b04a27b0bcb6ee2430aec12021-11-25T05:42:19ZThe Gene Ontology's Reference Genome Project: a unified framework for functional annotation across species.1553-734X1553-735810.1371/journal.pcbi.1000431https://doaj.org/article/d8dd6b33a0b04a27b0bcb6ee2430aec12009-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19578431/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358The Gene Ontology (GO) is a collaborative effort that provides structured vocabularies for annotating the molecular function, biological role, and cellular location of gene products in a highly systematic way and in a species-neutral manner with the aim of unifying the representation of gene function across different organisms. Each contributing member of the GO Consortium independently associates GO terms to gene products from the organism(s) they are annotating. Here we introduce the Reference Genome project, which brings together those independent efforts into a unified framework based on the evolutionary relationships between genes in these different organisms. The Reference Genome project has two primary goals: to increase the depth and breadth of annotations for genes in each of the organisms in the project, and to create data sets and tools that enable other genome annotation efforts to infer GO annotations for homologous genes in their organisms. In addition, the project has several important incidental benefits, such as increasing annotation consistency across genome databases, and providing important improvements to the GO's logical structure and biological content.Reference Genome Group of the Gene Ontology ConsortiumPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 5, Iss 7, p e1000431 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Reference Genome Group of the Gene Ontology Consortium The Gene Ontology's Reference Genome Project: a unified framework for functional annotation across species.
description	The Gene Ontology (GO) is a collaborative effort that provides structured vocabularies for annotating the molecular function, biological role, and cellular location of gene products in a highly systematic way and in a species-neutral manner with the aim of unifying the representation of gene function across different organisms. Each contributing member of the GO Consortium independently associates GO terms to gene products from the organism(s) they are annotating. Here we introduce the Reference Genome project, which brings together those independent efforts into a unified framework based on the evolutionary relationships between genes in these different organisms. The Reference Genome project has two primary goals: to increase the depth and breadth of annotations for genes in each of the organisms in the project, and to create data sets and tools that enable other genome annotation efforts to infer GO annotations for homologous genes in their organisms. In addition, the project has several important incidental benefits, such as increasing annotation consistency across genome databases, and providing important improvements to the GO's logical structure and biological content.
format	article
author	Reference Genome Group of the Gene Ontology Consortium
author_facet	Reference Genome Group of the Gene Ontology Consortium
author_sort	Reference Genome Group of the Gene Ontology Consortium
title	The Gene Ontology's Reference Genome Project: a unified framework for functional annotation across species.
title_short	The Gene Ontology's Reference Genome Project: a unified framework for functional annotation across species.
title_full	The Gene Ontology's Reference Genome Project: a unified framework for functional annotation across species.
title_fullStr	The Gene Ontology's Reference Genome Project: a unified framework for functional annotation across species.
title_full_unstemmed	The Gene Ontology's Reference Genome Project: a unified framework for functional annotation across species.
title_sort	gene ontology's reference genome project: a unified framework for functional annotation across species.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/d8dd6b33a0b04a27b0bcb6ee2430aec1
work_keys_str_mv	AT referencegenomegroupofthegeneontologyconsortium thegeneontologysreferencegenomeprojectaunifiedframeworkforfunctionalannotationacrossspecies AT referencegenomegroupofthegeneontologyconsortium geneontologysreferencegenomeprojectaunifiedframeworkforfunctionalannotationacrossspecies
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The Gene Ontology's Reference Genome Project: a unified framework for functional annotation across species.

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