Cognitive dysfunction in pediatric multiple sclerosis

Agnese Suppiej,1 Elisa Cainelli1,2 1Child Neurology and Clinical Neurophysiology, Pediatric University Hospital, Padua, Italy; 2Lifespan Cognitive Neuroscience Laboratory (LCNL), Department of General Psychology, University of Padua, Italy Abstract: Cognitive and neuropsychological impairments ar...

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Autores principales:	Suppiej A, Cainelli E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d8ddaaf07924497496fc0b6f0a0b39bd
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spelling	oai:doaj.org-article:d8ddaaf07924497496fc0b6f0a0b39bd2021-12-02T03:26:33ZCognitive dysfunction in pediatric multiple sclerosis1178-2021https://doaj.org/article/d8ddaaf07924497496fc0b6f0a0b39bd2014-07-01T00:00:00Zhttp://www.dovepress.com/cognitive-dysfunction-in-pediatric-multiple-sclerosis-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Agnese Suppiej,1 Elisa Cainelli1,2 1Child Neurology and Clinical Neurophysiology, Pediatric University Hospital, Padua, Italy; 2Lifespan Cognitive Neuroscience Laboratory (LCNL), Department of General Psychology, University of Padua, Italy Abstract: Cognitive and neuropsychological impairments are well documented in adult multiple sclerosis (MS). Research has only recently focused on cognitive disabilities in pediatric cases, highlighting some differences between pediatric and adult cases. Impairments in several functions have been reported in children, particularly in relation to attention, processing speed, visual–motor skills, and language. Language seems to be particularly vulnerable in pediatric MS, unlike in adults in whom it is usually preserved. Deficits in executive functions, which are considered MS-specific in adults, have been inconsistently reported in children. In children, as compared to adults, the relationship between cognitive dysfunctions and the two other main symptoms of MS, fatigue and psychiatric disorders, was poorly explored. Furthermore, data on the correlations of cognitive impairments with clinical and neuroimaging features are scarce in children, and the results are often incongruent; interestingly, involvement of corpus callosum and reduced thalamic volume differentiated patients identified as having a cognitive impairment from those without a cognitive impairment. Further studies about pediatric MS are needed in order to better understand the impact of the disease on brain development and the resulting effect on cognitive functions, particularly with respect to different therapeutic strategies. Keywords: central nervous system, child, deficit, IQ, inflammatory demyelination, neuropsychologicalSuppiej ACainelli EDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2014, Iss default, Pp 1385-1392 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Suppiej A Cainelli E Cognitive dysfunction in pediatric multiple sclerosis
description	Agnese Suppiej,1 Elisa Cainelli1,2 1Child Neurology and Clinical Neurophysiology, Pediatric University Hospital, Padua, Italy; 2Lifespan Cognitive Neuroscience Laboratory (LCNL), Department of General Psychology, University of Padua, Italy Abstract: Cognitive and neuropsychological impairments are well documented in adult multiple sclerosis (MS). Research has only recently focused on cognitive disabilities in pediatric cases, highlighting some differences between pediatric and adult cases. Impairments in several functions have been reported in children, particularly in relation to attention, processing speed, visual–motor skills, and language. Language seems to be particularly vulnerable in pediatric MS, unlike in adults in whom it is usually preserved. Deficits in executive functions, which are considered MS-specific in adults, have been inconsistently reported in children. In children, as compared to adults, the relationship between cognitive dysfunctions and the two other main symptoms of MS, fatigue and psychiatric disorders, was poorly explored. Furthermore, data on the correlations of cognitive impairments with clinical and neuroimaging features are scarce in children, and the results are often incongruent; interestingly, involvement of corpus callosum and reduced thalamic volume differentiated patients identified as having a cognitive impairment from those without a cognitive impairment. Further studies about pediatric MS are needed in order to better understand the impact of the disease on brain development and the resulting effect on cognitive functions, particularly with respect to different therapeutic strategies. Keywords: central nervous system, child, deficit, IQ, inflammatory demyelination, neuropsychological
format	article
author	Suppiej A Cainelli E
author_facet	Suppiej A Cainelli E
author_sort	Suppiej A
title	Cognitive dysfunction in pediatric multiple sclerosis
title_short	Cognitive dysfunction in pediatric multiple sclerosis
title_full	Cognitive dysfunction in pediatric multiple sclerosis
title_fullStr	Cognitive dysfunction in pediatric multiple sclerosis
title_full_unstemmed	Cognitive dysfunction in pediatric multiple sclerosis
title_sort	cognitive dysfunction in pediatric multiple sclerosis
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/d8ddaaf07924497496fc0b6f0a0b39bd
work_keys_str_mv	AT suppieja cognitivedysfunctioninpediatricmultiplesclerosis AT cainellie cognitivedysfunctioninpediatricmultiplesclerosis
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Cognitive dysfunction in pediatric multiple sclerosis

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