A Model of Minor Histocompatibility Antigens in Allogeneic Hematopoietic Cell Transplantation

Minor histocompatibility antigens (mHAg) composed of peptides presented by HLA molecules can cause immune responses involved in graft-versus-host disease (GVHD) and graft-versus-leukemia effects after allogeneic hematopoietic cell transplantation (HCT). The current study was designed to identify ind...

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Autores principales:	Paul J. Martin, David M. Levine, Barry E. Storer, Xiuwen Zheng, Deepti Jain, Ben Heavner, Brandon M. Norris, Daniel E. Geraghty, Stephen R. Spellman, Cassie L. Sather, Feinan Wu, John A. Hansen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	genetic variation graft-versus-host disease single nucleotide polymorphisms (SNPs) hematopoietic cell transplantation minor histocompatibility antigens Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d8ded45fc3324f79a80af8275498d5e9
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spelling	oai:doaj.org-article:d8ded45fc3324f79a80af8275498d5e92021-11-18T06:35:49ZA Model of Minor Histocompatibility Antigens in Allogeneic Hematopoietic Cell Transplantation1664-322410.3389/fimmu.2021.782152https://doaj.org/article/d8ded45fc3324f79a80af8275498d5e92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.782152/fullhttps://doaj.org/toc/1664-3224Minor histocompatibility antigens (mHAg) composed of peptides presented by HLA molecules can cause immune responses involved in graft-versus-host disease (GVHD) and graft-versus-leukemia effects after allogeneic hematopoietic cell transplantation (HCT). The current study was designed to identify individual graft-versus-host genomic mismatches associated with altered risks of acute or chronic GVHD or relapse after HCT between HLA-genotypically identical siblings. Our results demonstrate that in allogeneic HCT between a pair of HLA-identical siblings, a mHAg manifests as a set of peptides originating from annotated proteins and non-annotated open reading frames, which i) are encoded by a group of highly associated recipient genomic mismatches, ii) bind to HLA allotypes in the recipient, and iii) evoke a donor immune response. Attribution of the immune response and consequent clinical outcomes to individual peptide components within this set will likely differ from patient to patient according to their HLA types.Paul J. MartinPaul J. MartinDavid M. LevineBarry E. StorerXiuwen ZhengDeepti JainBen HeavnerBrandon M. NorrisDaniel E. GeraghtyStephen R. SpellmanCassie L. SatherFeinan WuJohn A. HansenJohn A. HansenFrontiers Media S.A.articlegenetic variationgraft-versus-host diseasesingle nucleotide polymorphisms (SNPs)hematopoietic cell transplantationminor histocompatibility antigensImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	genetic variation graft-versus-host disease single nucleotide polymorphisms (SNPs) hematopoietic cell transplantation minor histocompatibility antigens Immunologic diseases. Allergy RC581-607
spellingShingle	genetic variation graft-versus-host disease single nucleotide polymorphisms (SNPs) hematopoietic cell transplantation minor histocompatibility antigens Immunologic diseases. Allergy RC581-607 Paul J. Martin Paul J. Martin David M. Levine Barry E. Storer Xiuwen Zheng Deepti Jain Ben Heavner Brandon M. Norris Daniel E. Geraghty Stephen R. Spellman Cassie L. Sather Feinan Wu John A. Hansen John A. Hansen A Model of Minor Histocompatibility Antigens in Allogeneic Hematopoietic Cell Transplantation
description	Minor histocompatibility antigens (mHAg) composed of peptides presented by HLA molecules can cause immune responses involved in graft-versus-host disease (GVHD) and graft-versus-leukemia effects after allogeneic hematopoietic cell transplantation (HCT). The current study was designed to identify individual graft-versus-host genomic mismatches associated with altered risks of acute or chronic GVHD or relapse after HCT between HLA-genotypically identical siblings. Our results demonstrate that in allogeneic HCT between a pair of HLA-identical siblings, a mHAg manifests as a set of peptides originating from annotated proteins and non-annotated open reading frames, which i) are encoded by a group of highly associated recipient genomic mismatches, ii) bind to HLA allotypes in the recipient, and iii) evoke a donor immune response. Attribution of the immune response and consequent clinical outcomes to individual peptide components within this set will likely differ from patient to patient according to their HLA types.
format	article
author	Paul J. Martin Paul J. Martin David M. Levine Barry E. Storer Xiuwen Zheng Deepti Jain Ben Heavner Brandon M. Norris Daniel E. Geraghty Stephen R. Spellman Cassie L. Sather Feinan Wu John A. Hansen John A. Hansen
author_facet	Paul J. Martin Paul J. Martin David M. Levine Barry E. Storer Xiuwen Zheng Deepti Jain Ben Heavner Brandon M. Norris Daniel E. Geraghty Stephen R. Spellman Cassie L. Sather Feinan Wu John A. Hansen John A. Hansen
author_sort	Paul J. Martin
title	A Model of Minor Histocompatibility Antigens in Allogeneic Hematopoietic Cell Transplantation
title_short	A Model of Minor Histocompatibility Antigens in Allogeneic Hematopoietic Cell Transplantation
title_full	A Model of Minor Histocompatibility Antigens in Allogeneic Hematopoietic Cell Transplantation
title_fullStr	A Model of Minor Histocompatibility Antigens in Allogeneic Hematopoietic Cell Transplantation
title_full_unstemmed	A Model of Minor Histocompatibility Antigens in Allogeneic Hematopoietic Cell Transplantation
title_sort	model of minor histocompatibility antigens in allogeneic hematopoietic cell transplantation
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d8ded45fc3324f79a80af8275498d5e9
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A Model of Minor Histocompatibility Antigens in Allogeneic Hematopoietic Cell Transplantation

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