BCL-XL directly modulates RAS signalling to favour cancer cell stemness

BCL-XL provides a survival advantage to cancer cells even in the absence of apoptotic pressures. In this study, the authors show that BCL-XL interacts with RAS in a BH4-dependent manner and regulates RAS-mediated activation of pathways involved in the stemness feature of breast cancer cells.

Guardado en:

Detalles Bibliográficos
Autores principales:	Sophie de Carné Trécesson, Frédérique Souazé, Agnès Basseville, Anne-Charlotte Bernard, Jessie Pécot, Jonathan Lopez, Margaux Bessou, Kristopher A. Sarosiek, Anthony Letai, Sophie Barillé-Nion, Isabelle Valo, Olivier Coqueret, Catherine Guette, Mario Campone, Fabien Gautier, Philippe Paul Juin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d8e0c073724f4c88b43e7f5e0debd8b0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d8e0c073724f4c88b43e7f5e0debd8b0
record_format	dspace
spelling	oai:doaj.org-article:d8e0c073724f4c88b43e7f5e0debd8b02021-12-02T15:37:02ZBCL-XL directly modulates RAS signalling to favour cancer cell stemness10.1038/s41467-017-01079-12041-1723https://doaj.org/article/d8e0c073724f4c88b43e7f5e0debd8b02017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01079-1https://doaj.org/toc/2041-1723BCL-XL provides a survival advantage to cancer cells even in the absence of apoptotic pressures. In this study, the authors show that BCL-XL interacts with RAS in a BH4-dependent manner and regulates RAS-mediated activation of pathways involved in the stemness feature of breast cancer cells.Sophie de Carné TrécessonFrédérique SouazéAgnès BassevilleAnne-Charlotte BernardJessie PécotJonathan LopezMargaux BessouKristopher A. SarosiekAnthony LetaiSophie Barillé-NionIsabelle ValoOlivier CoqueretCatherine GuetteMario CamponeFabien GautierPhilippe Paul JuinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sophie de Carné Trécesson Frédérique Souazé Agnès Basseville Anne-Charlotte Bernard Jessie Pécot Jonathan Lopez Margaux Bessou Kristopher A. Sarosiek Anthony Letai Sophie Barillé-Nion Isabelle Valo Olivier Coqueret Catherine Guette Mario Campone Fabien Gautier Philippe Paul Juin BCL-XL directly modulates RAS signalling to favour cancer cell stemness
description	BCL-XL provides a survival advantage to cancer cells even in the absence of apoptotic pressures. In this study, the authors show that BCL-XL interacts with RAS in a BH4-dependent manner and regulates RAS-mediated activation of pathways involved in the stemness feature of breast cancer cells.
format	article
author	Sophie de Carné Trécesson Frédérique Souazé Agnès Basseville Anne-Charlotte Bernard Jessie Pécot Jonathan Lopez Margaux Bessou Kristopher A. Sarosiek Anthony Letai Sophie Barillé-Nion Isabelle Valo Olivier Coqueret Catherine Guette Mario Campone Fabien Gautier Philippe Paul Juin
author_facet	Sophie de Carné Trécesson Frédérique Souazé Agnès Basseville Anne-Charlotte Bernard Jessie Pécot Jonathan Lopez Margaux Bessou Kristopher A. Sarosiek Anthony Letai Sophie Barillé-Nion Isabelle Valo Olivier Coqueret Catherine Guette Mario Campone Fabien Gautier Philippe Paul Juin
author_sort	Sophie de Carné Trécesson
title	BCL-XL directly modulates RAS signalling to favour cancer cell stemness
title_short	BCL-XL directly modulates RAS signalling to favour cancer cell stemness
title_full	BCL-XL directly modulates RAS signalling to favour cancer cell stemness
title_fullStr	BCL-XL directly modulates RAS signalling to favour cancer cell stemness
title_full_unstemmed	BCL-XL directly modulates RAS signalling to favour cancer cell stemness
title_sort	bcl-xl directly modulates ras signalling to favour cancer cell stemness
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d8e0c073724f4c88b43e7f5e0debd8b0
work_keys_str_mv	AT sophiedecarnetrecesson bclxldirectlymodulatesrassignallingtofavourcancercellstemness AT frederiquesouaze bclxldirectlymodulatesrassignallingtofavourcancercellstemness AT agnesbasseville bclxldirectlymodulatesrassignallingtofavourcancercellstemness AT annecharlottebernard bclxldirectlymodulatesrassignallingtofavourcancercellstemness AT jessiepecot bclxldirectlymodulatesrassignallingtofavourcancercellstemness AT jonathanlopez bclxldirectlymodulatesrassignallingtofavourcancercellstemness AT margauxbessou bclxldirectlymodulatesrassignallingtofavourcancercellstemness AT kristopherasarosiek bclxldirectlymodulatesrassignallingtofavourcancercellstemness AT anthonyletai bclxldirectlymodulatesrassignallingtofavourcancercellstemness AT sophiebarillenion bclxldirectlymodulatesrassignallingtofavourcancercellstemness AT isabellevalo bclxldirectlymodulatesrassignallingtofavourcancercellstemness AT oliviercoqueret bclxldirectlymodulatesrassignallingtofavourcancercellstemness AT catherineguette bclxldirectlymodulatesrassignallingtofavourcancercellstemness AT mariocampone bclxldirectlymodulatesrassignallingtofavourcancercellstemness AT fabiengautier bclxldirectlymodulatesrassignallingtofavourcancercellstemness AT philippepauljuin bclxldirectlymodulatesrassignallingtofavourcancercellstemness
_version_	1718386262374612992

BCL-XL directly modulates RAS signalling to favour cancer cell stemness

Ejemplares similares