Chaperone mediated detection of small molecule target binding in cells

Quantitative profiling of small molecule-protein binding in cells can aid basic biochemical research and drug discovery. Here, the authors develop the Heat Shock Protein Inhibition Protein Stability Assay (HIPStA) as a high-throughput method to assess cellular target engagement and identify new drug...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kelvin F. Cho, Taylur P. Ma, Christopher M. Rose, Donald S. Kirkpatrick, Kebing Yu, Robert A. Blake
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d8e4230757ef4fa5aa0391581b106a4b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d8e4230757ef4fa5aa0391581b106a4b
record_format	dspace
spelling	oai:doaj.org-article:d8e4230757ef4fa5aa0391581b106a4b2021-12-02T14:40:29ZChaperone mediated detection of small molecule target binding in cells10.1038/s41467-019-14033-02041-1723https://doaj.org/article/d8e4230757ef4fa5aa0391581b106a4b2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14033-0https://doaj.org/toc/2041-1723Quantitative profiling of small molecule-protein binding in cells can aid basic biochemical research and drug discovery. Here, the authors develop the Heat Shock Protein Inhibition Protein Stability Assay (HIPStA) as a high-throughput method to assess cellular target engagement and identify new drug targets.Kelvin F. ChoTaylur P. MaChristopher M. RoseDonald S. KirkpatrickKebing YuRobert A. BlakeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kelvin F. Cho Taylur P. Ma Christopher M. Rose Donald S. Kirkpatrick Kebing Yu Robert A. Blake Chaperone mediated detection of small molecule target binding in cells
description	Quantitative profiling of small molecule-protein binding in cells can aid basic biochemical research and drug discovery. Here, the authors develop the Heat Shock Protein Inhibition Protein Stability Assay (HIPStA) as a high-throughput method to assess cellular target engagement and identify new drug targets.
format	article
author	Kelvin F. Cho Taylur P. Ma Christopher M. Rose Donald S. Kirkpatrick Kebing Yu Robert A. Blake
author_facet	Kelvin F. Cho Taylur P. Ma Christopher M. Rose Donald S. Kirkpatrick Kebing Yu Robert A. Blake
author_sort	Kelvin F. Cho
title	Chaperone mediated detection of small molecule target binding in cells
title_short	Chaperone mediated detection of small molecule target binding in cells
title_full	Chaperone mediated detection of small molecule target binding in cells
title_fullStr	Chaperone mediated detection of small molecule target binding in cells
title_full_unstemmed	Chaperone mediated detection of small molecule target binding in cells
title_sort	chaperone mediated detection of small molecule target binding in cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d8e4230757ef4fa5aa0391581b106a4b
work_keys_str_mv	AT kelvinfcho chaperonemediateddetectionofsmallmoleculetargetbindingincells AT taylurpma chaperonemediateddetectionofsmallmoleculetargetbindingincells AT christophermrose chaperonemediateddetectionofsmallmoleculetargetbindingincells AT donaldskirkpatrick chaperonemediateddetectionofsmallmoleculetargetbindingincells AT kebingyu chaperonemediateddetectionofsmallmoleculetargetbindingincells AT robertablake chaperonemediateddetectionofsmallmoleculetargetbindingincells
_version_	1718390266256162816

Chaperone mediated detection of small molecule target binding in cells

Ejemplares similares