Alternative Lengthening of Telomeres: Lessons to Be Learned from Telomeric DNA Double-Strand Break Repair

The study of the molecular pathways underlying cancer has given us important insights into how breaks in our DNA are repaired and the dire consequences that can occur when these processes are perturbed. Extensive research over the past 20 years has shown that the key molecular event underpinning a s...

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Autores principales:	Thomas Kent, David Clynes
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	telomeres alternative lengthening of telomeres ATRX break-induced replication double-strand break repair Genetics QH426-470
Acceso en línea:	https://doaj.org/article/d8e9d6c09e9240e096959f5fdc8b54bf
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spelling	oai:doaj.org-article:d8e9d6c09e9240e096959f5fdc8b54bf2021-11-25T17:41:24ZAlternative Lengthening of Telomeres: Lessons to Be Learned from Telomeric DNA Double-Strand Break Repair10.3390/genes121117342073-4425https://doaj.org/article/d8e9d6c09e9240e096959f5fdc8b54bf2021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4425/12/11/1734https://doaj.org/toc/2073-4425The study of the molecular pathways underlying cancer has given us important insights into how breaks in our DNA are repaired and the dire consequences that can occur when these processes are perturbed. Extensive research over the past 20 years has shown that the key molecular event underpinning a subset of cancers involves the deregulated repair of DNA double-strand breaks (DSBs) at telomeres, which in turn leads to telomere lengthening and the potential for replicative immortality. Here we discuss, in-depth, recent major breakthroughs in our understanding of the mechanisms underpinning this pathway known as the alternative lengthening of telomeres (ALT). We explore how this gives us important insights into how DSB repair at telomeres is regulated, with relevance to the cell-cycle-dependent regulation of repair, repair of stalled replication forks and the spatial regulation of DSB repair.Thomas KentDavid ClynesMDPI AGarticletelomeresalternative lengthening of telomeresATRXbreak-induced replicationdouble-strand break repairGeneticsQH426-470ENGenes, Vol 12, Iss 1734, p 1734 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	telomeres alternative lengthening of telomeres ATRX break-induced replication double-strand break repair Genetics QH426-470
spellingShingle	telomeres alternative lengthening of telomeres ATRX break-induced replication double-strand break repair Genetics QH426-470 Thomas Kent David Clynes Alternative Lengthening of Telomeres: Lessons to Be Learned from Telomeric DNA Double-Strand Break Repair
description	The study of the molecular pathways underlying cancer has given us important insights into how breaks in our DNA are repaired and the dire consequences that can occur when these processes are perturbed. Extensive research over the past 20 years has shown that the key molecular event underpinning a subset of cancers involves the deregulated repair of DNA double-strand breaks (DSBs) at telomeres, which in turn leads to telomere lengthening and the potential for replicative immortality. Here we discuss, in-depth, recent major breakthroughs in our understanding of the mechanisms underpinning this pathway known as the alternative lengthening of telomeres (ALT). We explore how this gives us important insights into how DSB repair at telomeres is regulated, with relevance to the cell-cycle-dependent regulation of repair, repair of stalled replication forks and the spatial regulation of DSB repair.
format	article
author	Thomas Kent David Clynes
author_facet	Thomas Kent David Clynes
author_sort	Thomas Kent
title	Alternative Lengthening of Telomeres: Lessons to Be Learned from Telomeric DNA Double-Strand Break Repair
title_short	Alternative Lengthening of Telomeres: Lessons to Be Learned from Telomeric DNA Double-Strand Break Repair
title_full	Alternative Lengthening of Telomeres: Lessons to Be Learned from Telomeric DNA Double-Strand Break Repair
title_fullStr	Alternative Lengthening of Telomeres: Lessons to Be Learned from Telomeric DNA Double-Strand Break Repair
title_full_unstemmed	Alternative Lengthening of Telomeres: Lessons to Be Learned from Telomeric DNA Double-Strand Break Repair
title_sort	alternative lengthening of telomeres: lessons to be learned from telomeric dna double-strand break repair
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d8e9d6c09e9240e096959f5fdc8b54bf
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Alternative Lengthening of Telomeres: Lessons to Be Learned from Telomeric DNA Double-Strand Break Repair

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