High dietary salt intake correlates with modulated Th17-Treg cell balance resulting in enhanced bone loss and impaired bone-microarchitecture in male mice

Abstract Osteoporosis is associated with reduced density and quality of bone leading to weakened skeleton thereby increasing the risk of fractures responsible for increased morbidity and mortality. Due to preference for western food style the consumption of salt intake in our diets has increased man...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hamid Y. Dar, Anjali Singh, Prashant Shukla, Rajaneesh Anupam, Rajesh K. Mondal, Pradyumna K. Mishra, Rupesh K. Srivastava
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d8ec2faffb614dd29ceab10a7343e8c0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d8ec2faffb614dd29ceab10a7343e8c0
record_format	dspace
spelling	oai:doaj.org-article:d8ec2faffb614dd29ceab10a7343e8c02021-12-02T15:08:26ZHigh dietary salt intake correlates with modulated Th17-Treg cell balance resulting in enhanced bone loss and impaired bone-microarchitecture in male mice10.1038/s41598-018-20896-y2045-2322https://doaj.org/article/d8ec2faffb614dd29ceab10a7343e8c02018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-20896-yhttps://doaj.org/toc/2045-2322Abstract Osteoporosis is associated with reduced density and quality of bone leading to weakened skeleton thereby increasing the risk of fractures responsible for increased morbidity and mortality. Due to preference for western food style the consumption of salt intake in our diets has increased many folds. High dietary salt intake has recently been linked with induction of Th17 cells along with impairment of Treg cells. Also, Th17 cells have been one of major players in the pathophysiology of various bone pathologies including osteoporosis. We thus hypothesized that high salt diet (HSD) intake would lead to enhanced bone loss by modulating Th17-Treg cell balance. In the present study, we report for the first time that HSD intake in male mice impairs both trabecular and cortical bone microarchitecture along with decreasing the mineral density and heterogeneity of bones. The HSD modulates host immune system and skews Treg-Th17 balance by promoting osteoclastogenic Th17 cells and inhibiting development of anti-osteoclastogenic Treg cells in mice. HSD also enhanced expression of proinflammatory cytokines (IL-6, TNF-α, RANKL and IL-17) and decreased the expression of anti-inflammatory cytokines (IL-10, IFN-γ). Taken together the present study for the first time establishes a strong correlation between high dietary salt intake and bone health via interplay between Th17-Treg cells.Hamid Y. DarAnjali SinghPrashant ShuklaRajaneesh AnupamRajesh K. MondalPradyumna K. MishraRupesh K. SrivastavaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hamid Y. Dar Anjali Singh Prashant Shukla Rajaneesh Anupam Rajesh K. Mondal Pradyumna K. Mishra Rupesh K. Srivastava High dietary salt intake correlates with modulated Th17-Treg cell balance resulting in enhanced bone loss and impaired bone-microarchitecture in male mice
description	Abstract Osteoporosis is associated with reduced density and quality of bone leading to weakened skeleton thereby increasing the risk of fractures responsible for increased morbidity and mortality. Due to preference for western food style the consumption of salt intake in our diets has increased many folds. High dietary salt intake has recently been linked with induction of Th17 cells along with impairment of Treg cells. Also, Th17 cells have been one of major players in the pathophysiology of various bone pathologies including osteoporosis. We thus hypothesized that high salt diet (HSD) intake would lead to enhanced bone loss by modulating Th17-Treg cell balance. In the present study, we report for the first time that HSD intake in male mice impairs both trabecular and cortical bone microarchitecture along with decreasing the mineral density and heterogeneity of bones. The HSD modulates host immune system and skews Treg-Th17 balance by promoting osteoclastogenic Th17 cells and inhibiting development of anti-osteoclastogenic Treg cells in mice. HSD also enhanced expression of proinflammatory cytokines (IL-6, TNF-α, RANKL and IL-17) and decreased the expression of anti-inflammatory cytokines (IL-10, IFN-γ). Taken together the present study for the first time establishes a strong correlation between high dietary salt intake and bone health via interplay between Th17-Treg cells.
format	article
author	Hamid Y. Dar Anjali Singh Prashant Shukla Rajaneesh Anupam Rajesh K. Mondal Pradyumna K. Mishra Rupesh K. Srivastava
author_facet	Hamid Y. Dar Anjali Singh Prashant Shukla Rajaneesh Anupam Rajesh K. Mondal Pradyumna K. Mishra Rupesh K. Srivastava
author_sort	Hamid Y. Dar
title	High dietary salt intake correlates with modulated Th17-Treg cell balance resulting in enhanced bone loss and impaired bone-microarchitecture in male mice
title_short	High dietary salt intake correlates with modulated Th17-Treg cell balance resulting in enhanced bone loss and impaired bone-microarchitecture in male mice
title_full	High dietary salt intake correlates with modulated Th17-Treg cell balance resulting in enhanced bone loss and impaired bone-microarchitecture in male mice
title_fullStr	High dietary salt intake correlates with modulated Th17-Treg cell balance resulting in enhanced bone loss and impaired bone-microarchitecture in male mice
title_full_unstemmed	High dietary salt intake correlates with modulated Th17-Treg cell balance resulting in enhanced bone loss and impaired bone-microarchitecture in male mice
title_sort	high dietary salt intake correlates with modulated th17-treg cell balance resulting in enhanced bone loss and impaired bone-microarchitecture in male mice
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d8ec2faffb614dd29ceab10a7343e8c0
work_keys_str_mv	AT hamidydar highdietarysaltintakecorrelateswithmodulatedth17tregcellbalanceresultinginenhancedbonelossandimpairedbonemicroarchitectureinmalemice AT anjalisingh highdietarysaltintakecorrelateswithmodulatedth17tregcellbalanceresultinginenhancedbonelossandimpairedbonemicroarchitectureinmalemice AT prashantshukla highdietarysaltintakecorrelateswithmodulatedth17tregcellbalanceresultinginenhancedbonelossandimpairedbonemicroarchitectureinmalemice AT rajaneeshanupam highdietarysaltintakecorrelateswithmodulatedth17tregcellbalanceresultinginenhancedbonelossandimpairedbonemicroarchitectureinmalemice AT rajeshkmondal highdietarysaltintakecorrelateswithmodulatedth17tregcellbalanceresultinginenhancedbonelossandimpairedbonemicroarchitectureinmalemice AT pradyumnakmishra highdietarysaltintakecorrelateswithmodulatedth17tregcellbalanceresultinginenhancedbonelossandimpairedbonemicroarchitectureinmalemice AT rupeshksrivastava highdietarysaltintakecorrelateswithmodulatedth17tregcellbalanceresultinginenhancedbonelossandimpairedbonemicroarchitectureinmalemice
_version_	1718388152660393984

High dietary salt intake correlates with modulated Th17-Treg cell balance resulting in enhanced bone loss and impaired bone-microarchitecture in male mice

Ejemplares similares