Collateral Damage: Detrimental Effect of Antibiotics on the Development of Protective Immune Memory

ABSTRACT Antibiotic intervention is an effective treatment strategy for many bacterial infections and liberates bacterial antigens and stimulatory products that can induce an inflammatory response. Despite the opportunity for bacterial killing to enhance the development of adaptive immunity, patient...

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Autores principales:	Joseph M. Benoun, Jasmine C. Labuda, Stephen J. McSorley
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/d8ecf2cc32ca478d86e26dd1385f3aad
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spelling	oai:doaj.org-article:d8ecf2cc32ca478d86e26dd1385f3aad2021-11-15T15:50:16ZCollateral Damage: Detrimental Effect of Antibiotics on the Development of Protective Immune Memory10.1128/mBio.01520-162150-7511https://doaj.org/article/d8ecf2cc32ca478d86e26dd1385f3aad2016-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01520-16https://doaj.org/toc/2150-7511ABSTRACT Antibiotic intervention is an effective treatment strategy for many bacterial infections and liberates bacterial antigens and stimulatory products that can induce an inflammatory response. Despite the opportunity for bacterial killing to enhance the development of adaptive immunity, patients treated successfully with antibiotics can suffer from reinfection. Studies in mouse models of Salmonella and Chlamydia infection also demonstrate that early antibiotic intervention reduces host protective immunity to subsequent infection. This heightened susceptibility to reinfection correlates with poor development of Th1 and antibody responses in antibiotic-treated mice but can be overcome by delayed antibiotic intervention, thus suggesting a requirement for sustained T cell stimulation for protection. Although the contribution of memory T cell subsets is imperfectly understood in both of these infection models, a protective role for noncirculating memory cells is suggested by recent studies. Together, these data propose a model where antibiotic treatment specifically interrupts tissue-resident memory T cell formation. Greater understanding of the mechanistic basis of this phenomenon might suggest therapeutic interventions to restore a protective memory response in antibiotic-treated patients, thus reducing the incidence of reinfection.Joseph M. BenounJasmine C. LabudaStephen J. McSorleyAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 6 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Joseph M. Benoun Jasmine C. Labuda Stephen J. McSorley Collateral Damage: Detrimental Effect of Antibiotics on the Development of Protective Immune Memory
description	ABSTRACT Antibiotic intervention is an effective treatment strategy for many bacterial infections and liberates bacterial antigens and stimulatory products that can induce an inflammatory response. Despite the opportunity for bacterial killing to enhance the development of adaptive immunity, patients treated successfully with antibiotics can suffer from reinfection. Studies in mouse models of Salmonella and Chlamydia infection also demonstrate that early antibiotic intervention reduces host protective immunity to subsequent infection. This heightened susceptibility to reinfection correlates with poor development of Th1 and antibody responses in antibiotic-treated mice but can be overcome by delayed antibiotic intervention, thus suggesting a requirement for sustained T cell stimulation for protection. Although the contribution of memory T cell subsets is imperfectly understood in both of these infection models, a protective role for noncirculating memory cells is suggested by recent studies. Together, these data propose a model where antibiotic treatment specifically interrupts tissue-resident memory T cell formation. Greater understanding of the mechanistic basis of this phenomenon might suggest therapeutic interventions to restore a protective memory response in antibiotic-treated patients, thus reducing the incidence of reinfection.
format	article
author	Joseph M. Benoun Jasmine C. Labuda Stephen J. McSorley
author_facet	Joseph M. Benoun Jasmine C. Labuda Stephen J. McSorley
author_sort	Joseph M. Benoun
title	Collateral Damage: Detrimental Effect of Antibiotics on the Development of Protective Immune Memory
title_short	Collateral Damage: Detrimental Effect of Antibiotics on the Development of Protective Immune Memory
title_full	Collateral Damage: Detrimental Effect of Antibiotics on the Development of Protective Immune Memory
title_fullStr	Collateral Damage: Detrimental Effect of Antibiotics on the Development of Protective Immune Memory
title_full_unstemmed	Collateral Damage: Detrimental Effect of Antibiotics on the Development of Protective Immune Memory
title_sort	collateral damage: detrimental effect of antibiotics on the development of protective immune memory
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/d8ecf2cc32ca478d86e26dd1385f3aad
work_keys_str_mv	AT josephmbenoun collateraldamagedetrimentaleffectofantibioticsonthedevelopmentofprotectiveimmunememory AT jasmineclabuda collateraldamagedetrimentaleffectofantibioticsonthedevelopmentofprotectiveimmunememory AT stephenjmcsorley collateraldamagedetrimentaleffectofantibioticsonthedevelopmentofprotectiveimmunememory
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Collateral Damage: Detrimental Effect of Antibiotics on the Development of Protective Immune Memory

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