Plasmodium sporozoite phospholipid scramblase interacts with mammalian carbamoyl-phosphate synthetase 1 to infect hepatocytes

After transmission of Plasmodium sporozoites from infected mosquitoes, parasites first infect hepatocytes. Here, Cha et al. identify a sporozoite ligand (phospholipid scramblase) and the hepatocytic receptor (carbamoyl-phosphate synthetase 1) as relevant for hepatocyte invasion and show that an anti...

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Main Authors:	Sung-Jae Cha, Min-Sik Kim, Chan Hyun Na, Marcelo Jacobs-Lorena
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/d8ed248f9c5e47a38f04d306b2a1b9da
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spelling	oai:doaj.org-article:d8ed248f9c5e47a38f04d306b2a1b9da2021-11-21T12:38:49ZPlasmodium sporozoite phospholipid scramblase interacts with mammalian carbamoyl-phosphate synthetase 1 to infect hepatocytes10.1038/s41467-021-27109-72041-1723https://doaj.org/article/d8ed248f9c5e47a38f04d306b2a1b9da2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27109-7https://doaj.org/toc/2041-1723After transmission of Plasmodium sporozoites from infected mosquitoes, parasites first infect hepatocytes. Here, Cha et al. identify a sporozoite ligand (phospholipid scramblase) and the hepatocytic receptor (carbamoyl-phosphate synthetase 1) as relevant for hepatocyte invasion and show that an antibody to hepatocyte-binding peptide 1 (HP1), which structurally mimics the sporozoite ligand, partially protects mice from infection.Sung-Jae ChaMin-Sik KimChan Hyun NaMarcelo Jacobs-LorenaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sung-Jae Cha Min-Sik Kim Chan Hyun Na Marcelo Jacobs-Lorena Plasmodium sporozoite phospholipid scramblase interacts with mammalian carbamoyl-phosphate synthetase 1 to infect hepatocytes
description	After transmission of Plasmodium sporozoites from infected mosquitoes, parasites first infect hepatocytes. Here, Cha et al. identify a sporozoite ligand (phospholipid scramblase) and the hepatocytic receptor (carbamoyl-phosphate synthetase 1) as relevant for hepatocyte invasion and show that an antibody to hepatocyte-binding peptide 1 (HP1), which structurally mimics the sporozoite ligand, partially protects mice from infection.
format	article
author	Sung-Jae Cha Min-Sik Kim Chan Hyun Na Marcelo Jacobs-Lorena
author_facet	Sung-Jae Cha Min-Sik Kim Chan Hyun Na Marcelo Jacobs-Lorena
author_sort	Sung-Jae Cha
title	Plasmodium sporozoite phospholipid scramblase interacts with mammalian carbamoyl-phosphate synthetase 1 to infect hepatocytes
title_short	Plasmodium sporozoite phospholipid scramblase interacts with mammalian carbamoyl-phosphate synthetase 1 to infect hepatocytes
title_full	Plasmodium sporozoite phospholipid scramblase interacts with mammalian carbamoyl-phosphate synthetase 1 to infect hepatocytes
title_fullStr	Plasmodium sporozoite phospholipid scramblase interacts with mammalian carbamoyl-phosphate synthetase 1 to infect hepatocytes
title_full_unstemmed	Plasmodium sporozoite phospholipid scramblase interacts with mammalian carbamoyl-phosphate synthetase 1 to infect hepatocytes
title_sort	plasmodium sporozoite phospholipid scramblase interacts with mammalian carbamoyl-phosphate synthetase 1 to infect hepatocytes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d8ed248f9c5e47a38f04d306b2a1b9da
work_keys_str_mv	AT sungjaecha plasmodiumsporozoitephospholipidscramblaseinteractswithmammaliancarbamoylphosphatesynthetase1toinfecthepatocytes AT minsikkim plasmodiumsporozoitephospholipidscramblaseinteractswithmammaliancarbamoylphosphatesynthetase1toinfecthepatocytes AT chanhyunna plasmodiumsporozoitephospholipidscramblaseinteractswithmammaliancarbamoylphosphatesynthetase1toinfecthepatocytes AT marcelojacobslorena plasmodiumsporozoitephospholipidscramblaseinteractswithmammaliancarbamoylphosphatesynthetase1toinfecthepatocytes
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Plasmodium sporozoite phospholipid scramblase interacts with mammalian carbamoyl-phosphate synthetase 1 to infect hepatocytes

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