Ocular surface disease in posttrabeculectomy/mitomycin C patients

Janice Lam,1,2 Tina T Wong,1–4 Louis Tong1–3,5 1Singapore National Eye Centre, Singapore; 2Singapore Eye Research Institute, Singapore; 3Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 4School of Materials Scie...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lam J, Wong TT, Tong L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/d8f39cd9438d4f4b861c640332b1e023
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d8f39cd9438d4f4b861c640332b1e023
record_format	dspace
spelling	oai:doaj.org-article:d8f39cd9438d4f4b861c640332b1e0232021-12-02T02:36:51ZOcular surface disease in posttrabeculectomy/mitomycin C patients1177-5483https://doaj.org/article/d8f39cd9438d4f4b861c640332b1e0232015-01-01T00:00:00Zhttp://www.dovepress.com/ocular-surface-disease-in-posttrabeculectomymitomycin-c-patients-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Janice Lam,1,2 Tina T Wong,1–4 Louis Tong1–3,5 1Singapore National Eye Centre, Singapore; 2Singapore Eye Research Institute, Singapore; 3Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 4School of Materials Science and Engineering, Nanyang Technological University, Singapore; 5Office of Clinical Sciences, Duke–National University of Singapore Graduate Medical School, Singapore Background: Our aim was to describe the demographics, risk factors, clinical signs, severity, and outcome of ocular surface disease (OSD) in 12 patients who had undergone trabeculectomy augmented with mitomycin C (MMC).Methods: Twelve glaucoma patients were referred to the Dry Eye Clinic (Singapore National Eye Centre) for further management of clinically significant OSD.Results: Of the 15 eyes from 12 patients, 14 were treated with MMC and one with 5-fluorouracil. Mean age was 69.3±10.6 years and two-thirds were male. The median interval before onset of dry eye symptoms after surgery was 13.5 months. Mean tear breakup time (TBUT) was 5.32 seconds and mean Schirmer score was 6.14 mm/5 min. Possible major risk factors for OSD in the cases include limbal stem cell deficiency occurring from exposure to antimetabolites, chronic use of antiglaucoma medications prior to surgery, and the preoperative status of the ocular surface prior to disease onset. Treatment of OSD resulted in improved best corrected visual acuity (BCVA) in 50% of the patients, with a median gain of two-line improvement in BCVA.Conclusion: OSD is a clinical problem often overlooked in patients who undergo antimetabolite-augmented filtration surgery. Recognition of the condition and appropriate treatment can improve patient symptoms and reduce health-care burdens on the economy. Keywords: cornea, glaucoma, ocular surface, trabeculectomyLam JWong TTTong LDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 187-191 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Lam J Wong TT Tong L Ocular surface disease in posttrabeculectomy/mitomycin C patients
description	Janice Lam,1,2 Tina T Wong,1–4 Louis Tong1–3,5 1Singapore National Eye Centre, Singapore; 2Singapore Eye Research Institute, Singapore; 3Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 4School of Materials Science and Engineering, Nanyang Technological University, Singapore; 5Office of Clinical Sciences, Duke–National University of Singapore Graduate Medical School, Singapore Background: Our aim was to describe the demographics, risk factors, clinical signs, severity, and outcome of ocular surface disease (OSD) in 12 patients who had undergone trabeculectomy augmented with mitomycin C (MMC).Methods: Twelve glaucoma patients were referred to the Dry Eye Clinic (Singapore National Eye Centre) for further management of clinically significant OSD.Results: Of the 15 eyes from 12 patients, 14 were treated with MMC and one with 5-fluorouracil. Mean age was 69.3±10.6 years and two-thirds were male. The median interval before onset of dry eye symptoms after surgery was 13.5 months. Mean tear breakup time (TBUT) was 5.32 seconds and mean Schirmer score was 6.14 mm/5 min. Possible major risk factors for OSD in the cases include limbal stem cell deficiency occurring from exposure to antimetabolites, chronic use of antiglaucoma medications prior to surgery, and the preoperative status of the ocular surface prior to disease onset. Treatment of OSD resulted in improved best corrected visual acuity (BCVA) in 50% of the patients, with a median gain of two-line improvement in BCVA.Conclusion: OSD is a clinical problem often overlooked in patients who undergo antimetabolite-augmented filtration surgery. Recognition of the condition and appropriate treatment can improve patient symptoms and reduce health-care burdens on the economy. Keywords: cornea, glaucoma, ocular surface, trabeculectomy
format	article
author	Lam J Wong TT Tong L
author_facet	Lam J Wong TT Tong L
author_sort	Lam J
title	Ocular surface disease in posttrabeculectomy/mitomycin C patients
title_short	Ocular surface disease in posttrabeculectomy/mitomycin C patients
title_full	Ocular surface disease in posttrabeculectomy/mitomycin C patients
title_fullStr	Ocular surface disease in posttrabeculectomy/mitomycin C patients
title_full_unstemmed	Ocular surface disease in posttrabeculectomy/mitomycin C patients
title_sort	ocular surface disease in posttrabeculectomy/mitomycin c patients
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/d8f39cd9438d4f4b861c640332b1e023
work_keys_str_mv	AT lamj ocularsurfacediseaseinposttrabeculectomymitomycincpatients AT wongtt ocularsurfacediseaseinposttrabeculectomymitomycincpatients AT tongl ocularsurfacediseaseinposttrabeculectomymitomycincpatients
_version_	1718402379494195200

Ocular surface disease in posttrabeculectomy/mitomycin C patients

Ejemplares similares