Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
Abnormal functions of RNA-binding proteins TAF15, FUS and TDP43 are associated with amyotrophic lateral sclerosis. Here, Kapeli et al. characterize the RNA targets of TAF15 and identify points of convergence and divergence between the targets of TAF15, FUS and TDP43 in several neuronal systems.
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Nature Portfolio
2016
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oai:doaj.org-article:d8f4356db05e4c6e9ae5ac8588f8d3102021-12-02T14:38:56ZDistinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses10.1038/ncomms121432041-1723https://doaj.org/article/d8f4356db05e4c6e9ae5ac8588f8d3102016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12143https://doaj.org/toc/2041-1723Abnormal functions of RNA-binding proteins TAF15, FUS and TDP43 are associated with amyotrophic lateral sclerosis. Here, Kapeli et al. characterize the RNA targets of TAF15 and identify points of convergence and divergence between the targets of TAF15, FUS and TDP43 in several neuronal systems.Katannya KapeliGabriel A. PrattAnthony Q. VuKasey R. HuttFernando J. MartinezBalaji SundararamanRanjan BatraPeter FreeseNicole J. LambertStephanie C. HuelgaSeung J. ChunTiffany Y. LiangJeremy ChangJohn P. DonohueLily ShiueJiayu ZhangHaining ZhuFranca CambiEdward KasarskisShawn HoonManuel Ares Jr.Christopher B. BurgeJohn RavitsFrank RigoGene W. YeoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Katannya Kapeli Gabriel A. Pratt Anthony Q. Vu Kasey R. Hutt Fernando J. Martinez Balaji Sundararaman Ranjan Batra Peter Freese Nicole J. Lambert Stephanie C. Huelga Seung J. Chun Tiffany Y. Liang Jeremy Chang John P. Donohue Lily Shiue Jiayu Zhang Haining Zhu Franca Cambi Edward Kasarskis Shawn Hoon Manuel Ares Jr. Christopher B. Burge John Ravits Frank Rigo Gene W. Yeo Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses |
| description |
Abnormal functions of RNA-binding proteins TAF15, FUS and TDP43 are associated with amyotrophic lateral sclerosis. Here, Kapeli et al. characterize the RNA targets of TAF15 and identify points of convergence and divergence between the targets of TAF15, FUS and TDP43 in several neuronal systems. |
| format |
article |
| author |
Katannya Kapeli Gabriel A. Pratt Anthony Q. Vu Kasey R. Hutt Fernando J. Martinez Balaji Sundararaman Ranjan Batra Peter Freese Nicole J. Lambert Stephanie C. Huelga Seung J. Chun Tiffany Y. Liang Jeremy Chang John P. Donohue Lily Shiue Jiayu Zhang Haining Zhu Franca Cambi Edward Kasarskis Shawn Hoon Manuel Ares Jr. Christopher B. Burge John Ravits Frank Rigo Gene W. Yeo |
| author_facet |
Katannya Kapeli Gabriel A. Pratt Anthony Q. Vu Kasey R. Hutt Fernando J. Martinez Balaji Sundararaman Ranjan Batra Peter Freese Nicole J. Lambert Stephanie C. Huelga Seung J. Chun Tiffany Y. Liang Jeremy Chang John P. Donohue Lily Shiue Jiayu Zhang Haining Zhu Franca Cambi Edward Kasarskis Shawn Hoon Manuel Ares Jr. Christopher B. Burge John Ravits Frank Rigo Gene W. Yeo |
| author_sort |
Katannya Kapeli |
| title |
Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses |
| title_short |
Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses |
| title_full |
Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses |
| title_fullStr |
Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses |
| title_full_unstemmed |
Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses |
| title_sort |
distinct and shared functions of als-associated proteins tdp-43, fus and taf15 revealed by multisystem analyses |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/d8f4356db05e4c6e9ae5ac8588f8d310 |
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