Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity
CB2 receptor agonists are developed as potential analgesics or immune-modulatory compounds. Here, the authors characterize the pharmacological properties of widely used CB2 receptor agonists and antagonists, recommending three that appear most suitable for in vitro and in vivostudies.
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Nature Portfolio
2017
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oai:doaj.org-article:d8fb448abc4444e3a10089f8b36e11e62021-12-02T15:38:43ZCannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity10.1038/ncomms139582041-1723https://doaj.org/article/d8fb448abc4444e3a10089f8b36e11e62017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13958https://doaj.org/toc/2041-1723CB2 receptor agonists are developed as potential analgesics or immune-modulatory compounds. Here, the authors characterize the pharmacological properties of widely used CB2 receptor agonists and antagonists, recommending three that appear most suitable for in vitro and in vivostudies.Marjolein SoethoudtUwe GretherJürgen FingerleTravis W. GrimFilomena FezzaLuciano de PetrocellisChristoph UllmerBenno RothenhäuslerCamille PerretNoortje van GilsDavid FinlayChrista MacDonaldAndrea ChiccaMarianela Dalghi GensJordyn StuartHenk de VriesNicolina MastrangeloLizi XiaGeorgios AlachouzosMarc P. BaggelaarAndrea MartellaElliot D. MockHui DengLaura H. HeitmanMark ConnorVincenzo Di MarzoJürg GertschAron H. LichtmanMauro MaccarronePal PacherMichelle GlassMario van der SteltNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
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Science Q Marjolein Soethoudt Uwe Grether Jürgen Fingerle Travis W. Grim Filomena Fezza Luciano de Petrocellis Christoph Ullmer Benno Rothenhäusler Camille Perret Noortje van Gils David Finlay Christa MacDonald Andrea Chicca Marianela Dalghi Gens Jordyn Stuart Henk de Vries Nicolina Mastrangelo Lizi Xia Georgios Alachouzos Marc P. Baggelaar Andrea Martella Elliot D. Mock Hui Deng Laura H. Heitman Mark Connor Vincenzo Di Marzo Jürg Gertsch Aron H. Lichtman Mauro Maccarrone Pal Pacher Michelle Glass Mario van der Stelt Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity |
| description |
CB2 receptor agonists are developed as potential analgesics or immune-modulatory compounds. Here, the authors characterize the pharmacological properties of widely used CB2 receptor agonists and antagonists, recommending three that appear most suitable for in vitro and in vivostudies. |
| format |
article |
| author |
Marjolein Soethoudt Uwe Grether Jürgen Fingerle Travis W. Grim Filomena Fezza Luciano de Petrocellis Christoph Ullmer Benno Rothenhäusler Camille Perret Noortje van Gils David Finlay Christa MacDonald Andrea Chicca Marianela Dalghi Gens Jordyn Stuart Henk de Vries Nicolina Mastrangelo Lizi Xia Georgios Alachouzos Marc P. Baggelaar Andrea Martella Elliot D. Mock Hui Deng Laura H. Heitman Mark Connor Vincenzo Di Marzo Jürg Gertsch Aron H. Lichtman Mauro Maccarrone Pal Pacher Michelle Glass Mario van der Stelt |
| author_facet |
Marjolein Soethoudt Uwe Grether Jürgen Fingerle Travis W. Grim Filomena Fezza Luciano de Petrocellis Christoph Ullmer Benno Rothenhäusler Camille Perret Noortje van Gils David Finlay Christa MacDonald Andrea Chicca Marianela Dalghi Gens Jordyn Stuart Henk de Vries Nicolina Mastrangelo Lizi Xia Georgios Alachouzos Marc P. Baggelaar Andrea Martella Elliot D. Mock Hui Deng Laura H. Heitman Mark Connor Vincenzo Di Marzo Jürg Gertsch Aron H. Lichtman Mauro Maccarrone Pal Pacher Michelle Glass Mario van der Stelt |
| author_sort |
Marjolein Soethoudt |
| title |
Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity |
| title_short |
Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity |
| title_full |
Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity |
| title_fullStr |
Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity |
| title_full_unstemmed |
Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity |
| title_sort |
cannabinoid cb2 receptor ligand profiling reveals biased signalling and off-target activity |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/d8fb448abc4444e3a10089f8b36e11e6 |
| work_keys_str_mv |
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