The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction

DOCK8-deficiency can cause atopic dermatitis but the mechanism is unclear. Here the authors use mice and human samples to show ARNT-independent DOCK8 inhibition of EPAS1 increases transcription of IL-31 in CD4+T cells, thus driving skin inflammation.

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Autores principales:	Kazuhiko Yamamura, Takehito Uruno, Akira Shiraishi, Yoshihiko Tanaka, Miho Ushijima, Takeshi Nakahara, Mayuki Watanabe, Makiko Kido-Nakahara, Ikuya Tsuge, Masutaka Furue, Yoshinori Fukui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d905189145bf4be9a4491bbce9d00563
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spelling	oai:doaj.org-article:d905189145bf4be9a4491bbce9d005632021-12-02T15:37:07ZThe transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction10.1038/ncomms139462041-1723https://doaj.org/article/d905189145bf4be9a4491bbce9d005632017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13946https://doaj.org/toc/2041-1723DOCK8-deficiency can cause atopic dermatitis but the mechanism is unclear. Here the authors use mice and human samples to show ARNT-independent DOCK8 inhibition of EPAS1 increases transcription of IL-31 in CD4+T cells, thus driving skin inflammation.Kazuhiko YamamuraTakehito UrunoAkira ShiraishiYoshihiko TanakaMiho UshijimaTakeshi NakaharaMayuki WatanabeMakiko Kido-NakaharaIkuya TsugeMasutaka FurueYoshinori FukuiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kazuhiko Yamamura Takehito Uruno Akira Shiraishi Yoshihiko Tanaka Miho Ushijima Takeshi Nakahara Mayuki Watanabe Makiko Kido-Nakahara Ikuya Tsuge Masutaka Furue Yoshinori Fukui The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction
description	DOCK8-deficiency can cause atopic dermatitis but the mechanism is unclear. Here the authors use mice and human samples to show ARNT-independent DOCK8 inhibition of EPAS1 increases transcription of IL-31 in CD4+T cells, thus driving skin inflammation.
format	article
author	Kazuhiko Yamamura Takehito Uruno Akira Shiraishi Yoshihiko Tanaka Miho Ushijima Takeshi Nakahara Mayuki Watanabe Makiko Kido-Nakahara Ikuya Tsuge Masutaka Furue Yoshinori Fukui
author_facet	Kazuhiko Yamamura Takehito Uruno Akira Shiraishi Yoshihiko Tanaka Miho Ushijima Takeshi Nakahara Mayuki Watanabe Makiko Kido-Nakahara Ikuya Tsuge Masutaka Furue Yoshinori Fukui
author_sort	Kazuhiko Yamamura
title	The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction
title_short	The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction
title_full	The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction
title_fullStr	The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction
title_full_unstemmed	The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction
title_sort	transcription factor epas1 links dock8 deficiency to atopic skin inflammation via il-31 induction
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d905189145bf4be9a4491bbce9d00563
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The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction

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