The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction

The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction

DOCK8-deficiency can cause atopic dermatitis but the mechanism is unclear. Here the authors use mice and human samples to show ARNT-independent DOCK8 inhibition of EPAS1 increases transcription of IL-31 in CD4+T cells, thus driving skin inflammation.

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Autores principales: Kazuhiko Yamamura, Takehito Uruno, Akira Shiraishi, Yoshihiko Tanaka, Miho Ushijima, Takeshi Nakahara, Mayuki Watanabe, Makiko Kido-Nakahara, Ikuya Tsuge, Masutaka Furue, Yoshinori Fukui
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/d905189145bf4be9a4491bbce9d00563
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