Phenolic Analysis and In Vitro Biological Activity of Red Wine, Pomace and Grape Seeds Oil Derived from <i>Vitis vinifera</i> L. cv. Montepulciano d’Abruzzo

Grape pomace is commonly considered a waste product of monovarietal red wine production. Methods: HPLC-DAD analysis was performed to determine the polyphenol and flavonoid contents of all the extracts obtained from Montepulciano d’Abruzzo red wine and grape skins whereas, GC-MS was applied to the de...

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Autores principales:	Adriano Mollica, Giuseppe Scioli, Alice Della Valle, Angelo Cichelli, Ettore Novellino, Marta Bauer, Wojciech Kamysz, Eulogio J. Llorent-Martínez, Maria Luisa Fernández-de Córdova, R. Castillo-López, Gunes Ak, Gokhan Zengin, Stefano Pieretti, Azzurra Stefanucci
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antioxidants enzyme inhibition grape pomace seeds phenolic Compounds anti-inflammatory potential Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/d9055d8764e741efb9361589a052fa28
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spelling	oai:doaj.org-article:d9055d8764e741efb9361589a052fa282021-11-25T16:26:38ZPhenolic Analysis and In Vitro Biological Activity of Red Wine, Pomace and Grape Seeds Oil Derived from <i>Vitis vinifera</i> L. cv. Montepulciano d’Abruzzo10.3390/antiox101117042076-3921https://doaj.org/article/d9055d8764e741efb9361589a052fa282021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1704https://doaj.org/toc/2076-3921Grape pomace is commonly considered a waste product of monovarietal red wine production. Methods: HPLC-DAD analysis was performed to determine the polyphenol and flavonoid contents of all the extracts obtained from Montepulciano d’Abruzzo red wine and grape skins whereas, GC-MS was applied to the determination of fatty acid composition in grape seeds oil. Biological characterization involves antioxidant and antimicrobial assays for all the extracts and seeds oil; Their ability to inhibit α-glucosidase, α-amylase, α-tyrosinase, and ChE enzymes was also detected, together with anti-inflammatory activity on wine, grape skin extracts, and seeds oil by lipoxygenase (5-LOX) and LPS-stimulated macrophage release assays. Data indicate significative polyphenols content (199.31 ± 7.21 mgGAE/g), antioxidant (CUPRAC assay (1036.98 mgTE/g)), enzymatic inhibition (α-tyrosinase: 151.30 ± 1.20 mgKAE/g) and anti-inflammatory activities for wine-organic extract 2, while the antimicrobial activity of grape skin decoction is higher than those reported by wine extracts on three bacterial strains. Interestingly only dealcoholized wine and wine-aqueous extract exerts inhibitory effects on α-glucosidase (20.62 ± 0.23 mmolACAE/g and 19.81 ± 0.03 mmolACAE/g, respectively), while seeds oil is rich in oleic and linoleic acids. These results confirm the strong antioxidant properties of Montepulciano d’Abruzzo grape pomace, suggesting the potential use of this waste product as functional food supplements in the human diet and in cosmeceutics.Adriano MollicaGiuseppe ScioliAlice Della ValleAngelo CichelliEttore NovellinoMarta BauerWojciech KamyszEulogio J. Llorent-MartínezMaria Luisa Fernández-de CórdovaR. Castillo-LópezGunes AkGokhan ZenginStefano PierettiAzzurra StefanucciMDPI AGarticleantioxidantsenzyme inhibitiongrape pomaceseedsphenolic Compoundsanti-inflammatory potentialTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1704, p 1704 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antioxidants enzyme inhibition grape pomace seeds phenolic Compounds anti-inflammatory potential Therapeutics. Pharmacology RM1-950
spellingShingle	antioxidants enzyme inhibition grape pomace seeds phenolic Compounds anti-inflammatory potential Therapeutics. Pharmacology RM1-950 Adriano Mollica Giuseppe Scioli Alice Della Valle Angelo Cichelli Ettore Novellino Marta Bauer Wojciech Kamysz Eulogio J. Llorent-Martínez Maria Luisa Fernández-de Córdova R. Castillo-López Gunes Ak Gokhan Zengin Stefano Pieretti Azzurra Stefanucci Phenolic Analysis and In Vitro Biological Activity of Red Wine, Pomace and Grape Seeds Oil Derived from <i>Vitis vinifera</i> L. cv. Montepulciano d’Abruzzo
description	Grape pomace is commonly considered a waste product of monovarietal red wine production. Methods: HPLC-DAD analysis was performed to determine the polyphenol and flavonoid contents of all the extracts obtained from Montepulciano d’Abruzzo red wine and grape skins whereas, GC-MS was applied to the determination of fatty acid composition in grape seeds oil. Biological characterization involves antioxidant and antimicrobial assays for all the extracts and seeds oil; Their ability to inhibit α-glucosidase, α-amylase, α-tyrosinase, and ChE enzymes was also detected, together with anti-inflammatory activity on wine, grape skin extracts, and seeds oil by lipoxygenase (5-LOX) and LPS-stimulated macrophage release assays. Data indicate significative polyphenols content (199.31 ± 7.21 mgGAE/g), antioxidant (CUPRAC assay (1036.98 mgTE/g)), enzymatic inhibition (α-tyrosinase: 151.30 ± 1.20 mgKAE/g) and anti-inflammatory activities for wine-organic extract 2, while the antimicrobial activity of grape skin decoction is higher than those reported by wine extracts on three bacterial strains. Interestingly only dealcoholized wine and wine-aqueous extract exerts inhibitory effects on α-glucosidase (20.62 ± 0.23 mmolACAE/g and 19.81 ± 0.03 mmolACAE/g, respectively), while seeds oil is rich in oleic and linoleic acids. These results confirm the strong antioxidant properties of Montepulciano d’Abruzzo grape pomace, suggesting the potential use of this waste product as functional food supplements in the human diet and in cosmeceutics.
format	article
author	Adriano Mollica Giuseppe Scioli Alice Della Valle Angelo Cichelli Ettore Novellino Marta Bauer Wojciech Kamysz Eulogio J. Llorent-Martínez Maria Luisa Fernández-de Córdova R. Castillo-López Gunes Ak Gokhan Zengin Stefano Pieretti Azzurra Stefanucci
author_facet	Adriano Mollica Giuseppe Scioli Alice Della Valle Angelo Cichelli Ettore Novellino Marta Bauer Wojciech Kamysz Eulogio J. Llorent-Martínez Maria Luisa Fernández-de Córdova R. Castillo-López Gunes Ak Gokhan Zengin Stefano Pieretti Azzurra Stefanucci
author_sort	Adriano Mollica
title	Phenolic Analysis and In Vitro Biological Activity of Red Wine, Pomace and Grape Seeds Oil Derived from <i>Vitis vinifera</i> L. cv. Montepulciano d’Abruzzo
title_short	Phenolic Analysis and In Vitro Biological Activity of Red Wine, Pomace and Grape Seeds Oil Derived from <i>Vitis vinifera</i> L. cv. Montepulciano d’Abruzzo
title_full	Phenolic Analysis and In Vitro Biological Activity of Red Wine, Pomace and Grape Seeds Oil Derived from <i>Vitis vinifera</i> L. cv. Montepulciano d’Abruzzo
title_fullStr	Phenolic Analysis and In Vitro Biological Activity of Red Wine, Pomace and Grape Seeds Oil Derived from <i>Vitis vinifera</i> L. cv. Montepulciano d’Abruzzo
title_full_unstemmed	Phenolic Analysis and In Vitro Biological Activity of Red Wine, Pomace and Grape Seeds Oil Derived from <i>Vitis vinifera</i> L. cv. Montepulciano d’Abruzzo
title_sort	phenolic analysis and in vitro biological activity of red wine, pomace and grape seeds oil derived from <i>vitis vinifera</i> l. cv. montepulciano d’abruzzo
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d9055d8764e741efb9361589a052fa28
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Phenolic Analysis and In Vitro Biological Activity of Red Wine, Pomace and Grape Seeds Oil Derived from <i>Vitis vinifera</i> L. cv. Montepulciano d’Abruzzo

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