Modeling light adaptation in circadian clock: prediction of the response that stabilizes entrainment.

Periods of biological clocks are close to but often different from the rotation period of the earth. Thus, the clocks of organisms must be adjusted to synchronize with day-night cycles. The primary signal that adjusts the clocks is light. In Neurospora, light transiently up-regulates the expression...

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Autores principales:	Kunichika Tsumoto, Gen Kurosawa, Tetsuya Yoshinaga, Kazuyuki Aihara
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d905b7eab139457badc82802447c42f2
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spelling	oai:doaj.org-article:d905b7eab139457badc82802447c42f22021-11-18T06:51:55ZModeling light adaptation in circadian clock: prediction of the response that stabilizes entrainment.1932-620310.1371/journal.pone.0020880https://doaj.org/article/d905b7eab139457badc82802447c42f22011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21698191/?tool=EBIhttps://doaj.org/toc/1932-6203Periods of biological clocks are close to but often different from the rotation period of the earth. Thus, the clocks of organisms must be adjusted to synchronize with day-night cycles. The primary signal that adjusts the clocks is light. In Neurospora, light transiently up-regulates the expression of specific clock genes. This molecular response to light is called light adaptation. Does light adaptation occur in other organisms? Using published experimental data, we first estimated the time course of the up-regulation rate of gene expression by light. Intriguingly, the estimated up-regulation rate was transient during light period in mice as well as Neurospora. Next, we constructed a computational model to consider how light adaptation had an effect on the entrainment of circadian oscillation to 24-h light-dark cycles. We found that cellular oscillations are more likely to be destabilized without light adaption especially when light intensity is very high. From the present results, we predict that the instability of circadian oscillations under 24-h light-dark cycles can be experimentally observed if light adaptation is altered. We conclude that the functional consequence of light adaptation is to increase the adjustability to 24-h light-dark cycles and then adapt to fluctuating environments in nature.Kunichika TsumotoGen KurosawaTetsuya YoshinagaKazuyuki AiharaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 6, p e20880 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kunichika Tsumoto Gen Kurosawa Tetsuya Yoshinaga Kazuyuki Aihara Modeling light adaptation in circadian clock: prediction of the response that stabilizes entrainment.
description	Periods of biological clocks are close to but often different from the rotation period of the earth. Thus, the clocks of organisms must be adjusted to synchronize with day-night cycles. The primary signal that adjusts the clocks is light. In Neurospora, light transiently up-regulates the expression of specific clock genes. This molecular response to light is called light adaptation. Does light adaptation occur in other organisms? Using published experimental data, we first estimated the time course of the up-regulation rate of gene expression by light. Intriguingly, the estimated up-regulation rate was transient during light period in mice as well as Neurospora. Next, we constructed a computational model to consider how light adaptation had an effect on the entrainment of circadian oscillation to 24-h light-dark cycles. We found that cellular oscillations are more likely to be destabilized without light adaption especially when light intensity is very high. From the present results, we predict that the instability of circadian oscillations under 24-h light-dark cycles can be experimentally observed if light adaptation is altered. We conclude that the functional consequence of light adaptation is to increase the adjustability to 24-h light-dark cycles and then adapt to fluctuating environments in nature.
format	article
author	Kunichika Tsumoto Gen Kurosawa Tetsuya Yoshinaga Kazuyuki Aihara
author_facet	Kunichika Tsumoto Gen Kurosawa Tetsuya Yoshinaga Kazuyuki Aihara
author_sort	Kunichika Tsumoto
title	Modeling light adaptation in circadian clock: prediction of the response that stabilizes entrainment.
title_short	Modeling light adaptation in circadian clock: prediction of the response that stabilizes entrainment.
title_full	Modeling light adaptation in circadian clock: prediction of the response that stabilizes entrainment.
title_fullStr	Modeling light adaptation in circadian clock: prediction of the response that stabilizes entrainment.
title_full_unstemmed	Modeling light adaptation in circadian clock: prediction of the response that stabilizes entrainment.
title_sort	modeling light adaptation in circadian clock: prediction of the response that stabilizes entrainment.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/d905b7eab139457badc82802447c42f2
work_keys_str_mv	AT kunichikatsumoto modelinglightadaptationincircadianclockpredictionoftheresponsethatstabilizesentrainment AT genkurosawa modelinglightadaptationincircadianclockpredictionoftheresponsethatstabilizesentrainment AT tetsuyayoshinaga modelinglightadaptationincircadianclockpredictionoftheresponsethatstabilizesentrainment AT kazuyukiaihara modelinglightadaptationincircadianclockpredictionoftheresponsethatstabilizesentrainment
_version_	1718424322347892736

Modeling light adaptation in circadian clock: prediction of the response that stabilizes entrainment.

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