The Role of BMP Signaling in Female Reproductive System Development and Function

Bone morphogenetic proteins (BMPs) are a group of multifunctional growth factors that belong to the transforming growth factor-β (TGF-β) superfamily of proteins. Originally identified by their ability to induce bone formation, they are now known as essential signaling molecules that regulate the dev...

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Autores principales:	Esmeralda Magro-Lopez, María Ángeles Muñoz-Fernández
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	female reproductive system embryonic development BMPs family BM signaling signal transduction human pluripotent stem cells Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/d906ce4859dd470fab878c4c753937ff
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spelling	oai:doaj.org-article:d906ce4859dd470fab878c4c753937ff2021-11-11T17:20:52ZThe Role of BMP Signaling in Female Reproductive System Development and Function10.3390/ijms2221119271422-00671661-6596https://doaj.org/article/d906ce4859dd470fab878c4c753937ff2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11927https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Bone morphogenetic proteins (BMPs) are a group of multifunctional growth factors that belong to the transforming growth factor-β (TGF-β) superfamily of proteins. Originally identified by their ability to induce bone formation, they are now known as essential signaling molecules that regulate the development and function of the female reproductive system (FRS). Several BMPs play key roles in aspects of reproductive system development. BMPs have also been described to be involved in the differentiation of human pluripotent stem cells (hPSCs) into reproductive system tissues or organoids. The role of BMPs in the reproductive system is still poorly understood and the use of FRS tissue or organoids generated from hPSCs would provide a powerful tool for the study of FRS development and the generation of new therapeutic perspectives for the treatment of FRS diseases. Therefore, the aim of this review is to summarize the current knowledge about BMP signaling in FRS development and function.Esmeralda Magro-LopezMaría Ángeles Muñoz-FernándezMDPI AGarticlefemale reproductive systemembryonic developmentBMPs familyBM signalingsignal transductionhuman pluripotent stem cellsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11927, p 11927 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	female reproductive system embryonic development BMPs family BM signaling signal transduction human pluripotent stem cells Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	female reproductive system embryonic development BMPs family BM signaling signal transduction human pluripotent stem cells Biology (General) QH301-705.5 Chemistry QD1-999 Esmeralda Magro-Lopez María Ángeles Muñoz-Fernández The Role of BMP Signaling in Female Reproductive System Development and Function
description	Bone morphogenetic proteins (BMPs) are a group of multifunctional growth factors that belong to the transforming growth factor-β (TGF-β) superfamily of proteins. Originally identified by their ability to induce bone formation, they are now known as essential signaling molecules that regulate the development and function of the female reproductive system (FRS). Several BMPs play key roles in aspects of reproductive system development. BMPs have also been described to be involved in the differentiation of human pluripotent stem cells (hPSCs) into reproductive system tissues or organoids. The role of BMPs in the reproductive system is still poorly understood and the use of FRS tissue or organoids generated from hPSCs would provide a powerful tool for the study of FRS development and the generation of new therapeutic perspectives for the treatment of FRS diseases. Therefore, the aim of this review is to summarize the current knowledge about BMP signaling in FRS development and function.
format	article
author	Esmeralda Magro-Lopez María Ángeles Muñoz-Fernández
author_facet	Esmeralda Magro-Lopez María Ángeles Muñoz-Fernández
author_sort	Esmeralda Magro-Lopez
title	The Role of BMP Signaling in Female Reproductive System Development and Function
title_short	The Role of BMP Signaling in Female Reproductive System Development and Function
title_full	The Role of BMP Signaling in Female Reproductive System Development and Function
title_fullStr	The Role of BMP Signaling in Female Reproductive System Development and Function
title_full_unstemmed	The Role of BMP Signaling in Female Reproductive System Development and Function
title_sort	role of bmp signaling in female reproductive system development and function
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d906ce4859dd470fab878c4c753937ff
work_keys_str_mv	AT esmeraldamagrolopez theroleofbmpsignalinginfemalereproductivesystemdevelopmentandfunction AT mariaangelesmunozfernandez theroleofbmpsignalinginfemalereproductivesystemdevelopmentandfunction AT esmeraldamagrolopez roleofbmpsignalinginfemalereproductivesystemdevelopmentandfunction AT mariaangelesmunozfernandez roleofbmpsignalinginfemalereproductivesystemdevelopmentandfunction
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The Role of BMP Signaling in Female Reproductive System Development and Function

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