Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data
Background: To describe and analyze the incidence and hospital outcomes of patients admitted with community-acquired pneumonia (CAP) according to Chronic Obstructive Pulmonary Disease (COPD) status and sex in Spanish hospitals from 2016 to 2019. Methods: We conducted a cohort study using national ho...
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MDPI AG
2021
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oai:doaj.org-article:d90c5f56bef34e41bbe74a256f4245442021-11-11T17:32:35ZCommunity-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data10.3390/jcm102148892077-0383https://doaj.org/article/d90c5f56bef34e41bbe74a256f4245442021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4889https://doaj.org/toc/2077-0383Background: To describe and analyze the incidence and hospital outcomes of patients admitted with community-acquired pneumonia (CAP) according to Chronic Obstructive Pulmonary Disease (COPD) status and sex in Spanish hospitals from 2016 to 2019. Methods: We conducted a cohort study using national hospital discharge data of all patients ≥40 years with CAP. Results: A total of 500,833 patients (59.0% men) was identified. Incidence of CAP increased over time. Age-adjusted incidence was 4.42-times higher in COPD patients. In-hospital mortality (IHM) was lower in men and women with COPD than in those without COPD (14.41% vs. 10.70% in men; 11.12% vs. 8.58%. in women; <i>p</i> < 0.001). The risk of dying in hospital increased with age, presence of several comorbidities (excluding T2DM that was a protective factor), and need for mechanical ventilation (non-invasive and invasive) during admission, irrespective of sex. Over time, the IHM decreased significantly in men and women with COPD. Men with COPD were significantly more likely to die in hospital than were COPD women (OR 1.13; 95% CI 1.07–1.21). Conclusions: Incidence of CAP was higher among subjects with COPD, although the effect of COPD was higher in men than in women. By contrast, IHM was lower in COPD patients, but men with COPD were significantly more likely to die in hospital than were COPD women.Javier de Miguel-DiezMarta Lopez-HerranzValentin Hernandez-BarreraJose M. de Miguel-YanesNapoleon Perez-FarinosJulia WärnbergDavid Carabantes-AlarconRodrigo Jimenez-GarciaAna Lopez-de-AndresMDPI AGarticlecommunity-acquired pneumoniaCOPDsexincidencein-hospital mortalityMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4889, p 4889 (2021) |
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community-acquired pneumonia COPD sex incidence in-hospital mortality Medicine R |
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community-acquired pneumonia COPD sex incidence in-hospital mortality Medicine R Javier de Miguel-Diez Marta Lopez-Herranz Valentin Hernandez-Barrera Jose M. de Miguel-Yanes Napoleon Perez-Farinos Julia Wärnberg David Carabantes-Alarcon Rodrigo Jimenez-Garcia Ana Lopez-de-Andres Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data |
description |
Background: To describe and analyze the incidence and hospital outcomes of patients admitted with community-acquired pneumonia (CAP) according to Chronic Obstructive Pulmonary Disease (COPD) status and sex in Spanish hospitals from 2016 to 2019. Methods: We conducted a cohort study using national hospital discharge data of all patients ≥40 years with CAP. Results: A total of 500,833 patients (59.0% men) was identified. Incidence of CAP increased over time. Age-adjusted incidence was 4.42-times higher in COPD patients. In-hospital mortality (IHM) was lower in men and women with COPD than in those without COPD (14.41% vs. 10.70% in men; 11.12% vs. 8.58%. in women; <i>p</i> < 0.001). The risk of dying in hospital increased with age, presence of several comorbidities (excluding T2DM that was a protective factor), and need for mechanical ventilation (non-invasive and invasive) during admission, irrespective of sex. Over time, the IHM decreased significantly in men and women with COPD. Men with COPD were significantly more likely to die in hospital than were COPD women (OR 1.13; 95% CI 1.07–1.21). Conclusions: Incidence of CAP was higher among subjects with COPD, although the effect of COPD was higher in men than in women. By contrast, IHM was lower in COPD patients, but men with COPD were significantly more likely to die in hospital than were COPD women. |
format |
article |
author |
Javier de Miguel-Diez Marta Lopez-Herranz Valentin Hernandez-Barrera Jose M. de Miguel-Yanes Napoleon Perez-Farinos Julia Wärnberg David Carabantes-Alarcon Rodrigo Jimenez-Garcia Ana Lopez-de-Andres |
author_facet |
Javier de Miguel-Diez Marta Lopez-Herranz Valentin Hernandez-Barrera Jose M. de Miguel-Yanes Napoleon Perez-Farinos Julia Wärnberg David Carabantes-Alarcon Rodrigo Jimenez-Garcia Ana Lopez-de-Andres |
author_sort |
Javier de Miguel-Diez |
title |
Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data |
title_short |
Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data |
title_full |
Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data |
title_fullStr |
Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data |
title_full_unstemmed |
Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data |
title_sort |
community-acquired pneumonia among patients with copd in spain from 2016 to 2019. cohort study assessing sex differences in the incidence and outcomes using hospital discharge data |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doaj.org/article/d90c5f56bef34e41bbe74a256f424544 |
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