Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data

Background: To describe and analyze the incidence and hospital outcomes of patients admitted with community-acquired pneumonia (CAP) according to Chronic Obstructive Pulmonary Disease (COPD) status and sex in Spanish hospitals from 2016 to 2019. Methods: We conducted a cohort study using national ho...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Javier de Miguel-Diez, Marta Lopez-Herranz, Valentin Hernandez-Barrera, Jose M. de Miguel-Yanes, Napoleon Perez-Farinos, Julia Wärnberg, David Carabantes-Alarcon, Rodrigo Jimenez-Garcia, Ana Lopez-de-Andres
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
sex
R
Acceso en línea:https://doaj.org/article/d90c5f56bef34e41bbe74a256f424544
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:d90c5f56bef34e41bbe74a256f424544
record_format dspace
spelling oai:doaj.org-article:d90c5f56bef34e41bbe74a256f4245442021-11-11T17:32:35ZCommunity-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data10.3390/jcm102148892077-0383https://doaj.org/article/d90c5f56bef34e41bbe74a256f4245442021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4889https://doaj.org/toc/2077-0383Background: To describe and analyze the incidence and hospital outcomes of patients admitted with community-acquired pneumonia (CAP) according to Chronic Obstructive Pulmonary Disease (COPD) status and sex in Spanish hospitals from 2016 to 2019. Methods: We conducted a cohort study using national hospital discharge data of all patients ≥40 years with CAP. Results: A total of 500,833 patients (59.0% men) was identified. Incidence of CAP increased over time. Age-adjusted incidence was 4.42-times higher in COPD patients. In-hospital mortality (IHM) was lower in men and women with COPD than in those without COPD (14.41% vs. 10.70% in men; 11.12% vs. 8.58%. in women; <i>p</i> < 0.001). The risk of dying in hospital increased with age, presence of several comorbidities (excluding T2DM that was a protective factor), and need for mechanical ventilation (non-invasive and invasive) during admission, irrespective of sex. Over time, the IHM decreased significantly in men and women with COPD. Men with COPD were significantly more likely to die in hospital than were COPD women (OR 1.13; 95% CI 1.07–1.21). Conclusions: Incidence of CAP was higher among subjects with COPD, although the effect of COPD was higher in men than in women. By contrast, IHM was lower in COPD patients, but men with COPD were significantly more likely to die in hospital than were COPD women.Javier de Miguel-DiezMarta Lopez-HerranzValentin Hernandez-BarreraJose M. de Miguel-YanesNapoleon Perez-FarinosJulia WärnbergDavid Carabantes-AlarconRodrigo Jimenez-GarciaAna Lopez-de-AndresMDPI AGarticlecommunity-acquired pneumoniaCOPDsexincidencein-hospital mortalityMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4889, p 4889 (2021)
institution DOAJ
collection DOAJ
language EN
topic community-acquired pneumonia
COPD
sex
incidence
in-hospital mortality
Medicine
R
spellingShingle community-acquired pneumonia
COPD
sex
incidence
in-hospital mortality
Medicine
R
Javier de Miguel-Diez
Marta Lopez-Herranz
Valentin Hernandez-Barrera
Jose M. de Miguel-Yanes
Napoleon Perez-Farinos
Julia Wärnberg
David Carabantes-Alarcon
Rodrigo Jimenez-Garcia
Ana Lopez-de-Andres
Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data
description Background: To describe and analyze the incidence and hospital outcomes of patients admitted with community-acquired pneumonia (CAP) according to Chronic Obstructive Pulmonary Disease (COPD) status and sex in Spanish hospitals from 2016 to 2019. Methods: We conducted a cohort study using national hospital discharge data of all patients ≥40 years with CAP. Results: A total of 500,833 patients (59.0% men) was identified. Incidence of CAP increased over time. Age-adjusted incidence was 4.42-times higher in COPD patients. In-hospital mortality (IHM) was lower in men and women with COPD than in those without COPD (14.41% vs. 10.70% in men; 11.12% vs. 8.58%. in women; <i>p</i> < 0.001). The risk of dying in hospital increased with age, presence of several comorbidities (excluding T2DM that was a protective factor), and need for mechanical ventilation (non-invasive and invasive) during admission, irrespective of sex. Over time, the IHM decreased significantly in men and women with COPD. Men with COPD were significantly more likely to die in hospital than were COPD women (OR 1.13; 95% CI 1.07–1.21). Conclusions: Incidence of CAP was higher among subjects with COPD, although the effect of COPD was higher in men than in women. By contrast, IHM was lower in COPD patients, but men with COPD were significantly more likely to die in hospital than were COPD women.
format article
author Javier de Miguel-Diez
Marta Lopez-Herranz
Valentin Hernandez-Barrera
Jose M. de Miguel-Yanes
Napoleon Perez-Farinos
Julia Wärnberg
David Carabantes-Alarcon
Rodrigo Jimenez-Garcia
Ana Lopez-de-Andres
author_facet Javier de Miguel-Diez
Marta Lopez-Herranz
Valentin Hernandez-Barrera
Jose M. de Miguel-Yanes
Napoleon Perez-Farinos
Julia Wärnberg
David Carabantes-Alarcon
Rodrigo Jimenez-Garcia
Ana Lopez-de-Andres
author_sort Javier de Miguel-Diez
title Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data
title_short Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data
title_full Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data
title_fullStr Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data
title_full_unstemmed Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data
title_sort community-acquired pneumonia among patients with copd in spain from 2016 to 2019. cohort study assessing sex differences in the incidence and outcomes using hospital discharge data
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/d90c5f56bef34e41bbe74a256f424544
work_keys_str_mv AT javierdemigueldiez communityacquiredpneumoniaamongpatientswithcopdinspainfrom2016to2019cohortstudyassessingsexdifferencesintheincidenceandoutcomesusinghospitaldischargedata
AT martalopezherranz communityacquiredpneumoniaamongpatientswithcopdinspainfrom2016to2019cohortstudyassessingsexdifferencesintheincidenceandoutcomesusinghospitaldischargedata
AT valentinhernandezbarrera communityacquiredpneumoniaamongpatientswithcopdinspainfrom2016to2019cohortstudyassessingsexdifferencesintheincidenceandoutcomesusinghospitaldischargedata
AT josemdemiguelyanes communityacquiredpneumoniaamongpatientswithcopdinspainfrom2016to2019cohortstudyassessingsexdifferencesintheincidenceandoutcomesusinghospitaldischargedata
AT napoleonperezfarinos communityacquiredpneumoniaamongpatientswithcopdinspainfrom2016to2019cohortstudyassessingsexdifferencesintheincidenceandoutcomesusinghospitaldischargedata
AT juliawarnberg communityacquiredpneumoniaamongpatientswithcopdinspainfrom2016to2019cohortstudyassessingsexdifferencesintheincidenceandoutcomesusinghospitaldischargedata
AT davidcarabantesalarcon communityacquiredpneumoniaamongpatientswithcopdinspainfrom2016to2019cohortstudyassessingsexdifferencesintheincidenceandoutcomesusinghospitaldischargedata
AT rodrigojimenezgarcia communityacquiredpneumoniaamongpatientswithcopdinspainfrom2016to2019cohortstudyassessingsexdifferencesintheincidenceandoutcomesusinghospitaldischargedata
AT analopezdeandres communityacquiredpneumoniaamongpatientswithcopdinspainfrom2016to2019cohortstudyassessingsexdifferencesintheincidenceandoutcomesusinghospitaldischargedata
_version_ 1718432091659567104