Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines

Vitamin B3 derivatives display a range of biological activities. Here, the authors report the synthesis of meta-aminoaryl nicotinates, derivatives of vitamin B3, and their late-stage conjugation with (hetero)arylamines, ultimately expanding the chemical space for biomedical research.

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Autores principales:	Begur Vasanthkumar Varun, Kannan Vaithegi, Sihyeong Yi, Seung Bum Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d90d781d2ec1448b8bf09971a769738f
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spelling	oai:doaj.org-article:d90d781d2ec1448b8bf09971a769738f2021-12-02T14:16:56ZNature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines10.1038/s41467-020-19610-22041-1723https://doaj.org/article/d90d781d2ec1448b8bf09971a769738f2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19610-2https://doaj.org/toc/2041-1723Vitamin B3 derivatives display a range of biological activities. Here, the authors report the synthesis of meta-aminoaryl nicotinates, derivatives of vitamin B3, and their late-stage conjugation with (hetero)arylamines, ultimately expanding the chemical space for biomedical research.Begur Vasanthkumar VarunKannan VaithegiSihyeong YiSeung Bum ParkNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Begur Vasanthkumar Varun Kannan Vaithegi Sihyeong Yi Seung Bum Park Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines
description	Vitamin B3 derivatives display a range of biological activities. Here, the authors report the synthesis of meta-aminoaryl nicotinates, derivatives of vitamin B3, and their late-stage conjugation with (hetero)arylamines, ultimately expanding the chemical space for biomedical research.
format	article
author	Begur Vasanthkumar Varun Kannan Vaithegi Sihyeong Yi Seung Bum Park
author_facet	Begur Vasanthkumar Varun Kannan Vaithegi Sihyeong Yi Seung Bum Park
author_sort	Begur Vasanthkumar Varun
title	Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines
title_short	Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines
title_full	Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines
title_fullStr	Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines
title_full_unstemmed	Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines
title_sort	nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin b3 to (hetero)arylamines
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d90d781d2ec1448b8bf09971a769738f
work_keys_str_mv	AT begurvasanthkumarvarun natureinspiredremodelingofazaindolestometaaminoarylnicotinatesforlatestageconjugationofvitaminb3toheteroarylamines AT kannanvaithegi natureinspiredremodelingofazaindolestometaaminoarylnicotinatesforlatestageconjugationofvitaminb3toheteroarylamines AT sihyeongyi natureinspiredremodelingofazaindolestometaaminoarylnicotinatesforlatestageconjugationofvitaminb3toheteroarylamines AT seungbumpark natureinspiredremodelingofazaindolestometaaminoarylnicotinatesforlatestageconjugationofvitaminb3toheteroarylamines
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Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines

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