ST2 and regulatory T cells in the colorectal adenoma/carcinoma microenvironment: implications for diseases progression and prognosis

Abstract ST2 (also known as IL1RL1) is the critical functional receptor for interleukin (IL)-33 in stimulating regulatory T cell (Treg) expansion and function in physiological and pathological conditions. We examined the correlation between ST2 cell expression and FoxP3 positive Tregs in both colore...

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Autores principales:	Guanglin Cui, Aping Yuan, Zhenfeng Li, Rasmus Goll, Jon Florholmen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d90dd0a48d9840b7b76144f3759f3f7c
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spelling	oai:doaj.org-article:d90dd0a48d9840b7b76144f3759f3f7c2021-12-02T18:17:54ZST2 and regulatory T cells in the colorectal adenoma/carcinoma microenvironment: implications for diseases progression and prognosis10.1038/s41598-020-62502-02045-2322https://doaj.org/article/d90dd0a48d9840b7b76144f3759f3f7c2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-62502-0https://doaj.org/toc/2045-2322Abstract ST2 (also known as IL1RL1) is the critical functional receptor for interleukin (IL)-33 in stimulating regulatory T cell (Treg) expansion and function in physiological and pathological conditions. We examined the correlation between ST2 cell expression and FoxP3 positive Tregs in both colorectal adenoma and cancer (CRC) microenvironment by real-time PCR, immunohistochemistry (IHC) and double immunofluorescences. The clinicopathological and prognostic significance of cellular ST2-positive cells and FoxP3-positive Tregs in patients with adenoma and CRC were evaluated. Real-time PCR results revealed increased expression levels of ST2 and FoxP3 mRNAs in both adenoma and CRC tissues as compared with control tissues. IHC analysis confirmed increased densities of ST2-positive cells in both the adenoma/CRC epithelium and stroma, which show a close positive linear association with the densities of FoxP3-positive Tregs in respective compartments. Pathological feature analysis showed that densities of ST2-positive cells in the tumor stroma were notably associated with degree of dysplastic grading in patients with adenoma, and disease stages and lymph node metastasis in patients with CRC. Kaplan-Meier survival curves suggested that CRC patients with high densities of ST2-positive cells in the stroma tend to have a shorter overall survival. We therefore concluded that increased densities of ST2-postive cells relate to Treg accumulation within the adenoma/CRC microenvironment, suggesting the IL-33/ST2 pathway as a potential contributor for immunosuppressive milieu formation that impact disease stage and prognosis in patients with CRC.Guanglin CuiAping YuanZhenfeng LiRasmus GollJon FlorholmenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guanglin Cui Aping Yuan Zhenfeng Li Rasmus Goll Jon Florholmen ST2 and regulatory T cells in the colorectal adenoma/carcinoma microenvironment: implications for diseases progression and prognosis
description	Abstract ST2 (also known as IL1RL1) is the critical functional receptor for interleukin (IL)-33 in stimulating regulatory T cell (Treg) expansion and function in physiological and pathological conditions. We examined the correlation between ST2 cell expression and FoxP3 positive Tregs in both colorectal adenoma and cancer (CRC) microenvironment by real-time PCR, immunohistochemistry (IHC) and double immunofluorescences. The clinicopathological and prognostic significance of cellular ST2-positive cells and FoxP3-positive Tregs in patients with adenoma and CRC were evaluated. Real-time PCR results revealed increased expression levels of ST2 and FoxP3 mRNAs in both adenoma and CRC tissues as compared with control tissues. IHC analysis confirmed increased densities of ST2-positive cells in both the adenoma/CRC epithelium and stroma, which show a close positive linear association with the densities of FoxP3-positive Tregs in respective compartments. Pathological feature analysis showed that densities of ST2-positive cells in the tumor stroma were notably associated with degree of dysplastic grading in patients with adenoma, and disease stages and lymph node metastasis in patients with CRC. Kaplan-Meier survival curves suggested that CRC patients with high densities of ST2-positive cells in the stroma tend to have a shorter overall survival. We therefore concluded that increased densities of ST2-postive cells relate to Treg accumulation within the adenoma/CRC microenvironment, suggesting the IL-33/ST2 pathway as a potential contributor for immunosuppressive milieu formation that impact disease stage and prognosis in patients with CRC.
format	article
author	Guanglin Cui Aping Yuan Zhenfeng Li Rasmus Goll Jon Florholmen
author_facet	Guanglin Cui Aping Yuan Zhenfeng Li Rasmus Goll Jon Florholmen
author_sort	Guanglin Cui
title	ST2 and regulatory T cells in the colorectal adenoma/carcinoma microenvironment: implications for diseases progression and prognosis
title_short	ST2 and regulatory T cells in the colorectal adenoma/carcinoma microenvironment: implications for diseases progression and prognosis
title_full	ST2 and regulatory T cells in the colorectal adenoma/carcinoma microenvironment: implications for diseases progression and prognosis
title_fullStr	ST2 and regulatory T cells in the colorectal adenoma/carcinoma microenvironment: implications for diseases progression and prognosis
title_full_unstemmed	ST2 and regulatory T cells in the colorectal adenoma/carcinoma microenvironment: implications for diseases progression and prognosis
title_sort	st2 and regulatory t cells in the colorectal adenoma/carcinoma microenvironment: implications for diseases progression and prognosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d90dd0a48d9840b7b76144f3759f3f7c
work_keys_str_mv	AT guanglincui st2andregulatorytcellsinthecolorectaladenomacarcinomamicroenvironmentimplicationsfordiseasesprogressionandprognosis AT apingyuan st2andregulatorytcellsinthecolorectaladenomacarcinomamicroenvironmentimplicationsfordiseasesprogressionandprognosis AT zhenfengli st2andregulatorytcellsinthecolorectaladenomacarcinomamicroenvironmentimplicationsfordiseasesprogressionandprognosis AT rasmusgoll st2andregulatorytcellsinthecolorectaladenomacarcinomamicroenvironmentimplicationsfordiseasesprogressionandprognosis AT jonflorholmen st2andregulatorytcellsinthecolorectaladenomacarcinomamicroenvironmentimplicationsfordiseasesprogressionandprognosis
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ST2 and regulatory T cells in the colorectal adenoma/carcinoma microenvironment: implications for diseases progression and prognosis

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