Augmenting drug–carrier compatibility improves tumour nanotherapy efficacy

Augmenting drug–carrier compatibility improves tumour nanotherapy efficacy

The in vivoanticancer efficacy of nanoparticle-mediated drug delivery depends on the association between the drug and its carrier. Here, the authors use FRET to show that the drug hydrophobicity, and miscibility with the carrier, influence nanoparticle accumulation in murine tumour models.

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Bibliographic Details
Main Authors: Yiming Zhao, François Fay, Sjoerd Hak, Jose Manuel Perez-Aguilar, Brenda L. Sanchez-Gaytan, Brandon Goode, Raphaël Duivenvoorden, Catharina de Lange Davies, Astrid Bjørkøy, Harel Weinstein, Zahi A. Fayad, Carlos Pérez-Medina, Willem J. M. Mulder
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
Q
Online Access:https://doaj.org/article/d90fceee65ae4c4ca9f5fa1e73acfa06
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Summary:The in vivoanticancer efficacy of nanoparticle-mediated drug delivery depends on the association between the drug and its carrier. Here, the authors use FRET to show that the drug hydrophobicity, and miscibility with the carrier, influence nanoparticle accumulation in murine tumour models.

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