Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging

In Alzheimer’s disease (AD), neural hyperactivity has been shown to occur in the regions surrounding Aβ plaques. Here, the authors use in vivotwo-photon imaging in mouse models of AD and report abnormal glutamate dynamics in the vicinity of plaques which can be partially restored via GLT-1 upregulat...

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Autores principales:	J. K. Hefendehl, J. LeDue, R. W. Y. Ko, J. Mahler, T. H. Murphy, B. A. MacVicar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d9104616d02d4c26b9d2688bacd0217d
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spelling	oai:doaj.org-article:d9104616d02d4c26b9d2688bacd0217d2021-12-02T16:57:03ZMapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging10.1038/ncomms134412041-1723https://doaj.org/article/d9104616d02d4c26b9d2688bacd0217d2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13441https://doaj.org/toc/2041-1723In Alzheimer’s disease (AD), neural hyperactivity has been shown to occur in the regions surrounding Aβ plaques. Here, the authors use in vivotwo-photon imaging in mouse models of AD and report abnormal glutamate dynamics in the vicinity of plaques which can be partially restored via GLT-1 upregulation through Ceftriaxone treatment.J. K. HefendehlJ. LeDueR. W. Y. KoJ. MahlerT. H. MurphyB. A. MacVicarNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q J. K. Hefendehl J. LeDue R. W. Y. Ko J. Mahler T. H. Murphy B. A. MacVicar Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging
description	In Alzheimer’s disease (AD), neural hyperactivity has been shown to occur in the regions surrounding Aβ plaques. Here, the authors use in vivotwo-photon imaging in mouse models of AD and report abnormal glutamate dynamics in the vicinity of plaques which can be partially restored via GLT-1 upregulation through Ceftriaxone treatment.
format	article
author	J. K. Hefendehl J. LeDue R. W. Y. Ko J. Mahler T. H. Murphy B. A. MacVicar
author_facet	J. K. Hefendehl J. LeDue R. W. Y. Ko J. Mahler T. H. Murphy B. A. MacVicar
author_sort	J. K. Hefendehl
title	Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging
title_short	Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging
title_full	Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging
title_fullStr	Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging
title_full_unstemmed	Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging
title_sort	mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding aβ plaques by iglusnfr two-photon imaging
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d9104616d02d4c26b9d2688bacd0217d
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Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging

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