Polystyrene microplastic particles induce endothelial activation

Due to its increasing production, durability and multiple applications, plastic is a material we encounter every day. Small plastic particles from the μm to the mm range are classified as microplastics and produced for cosmetic and medical products, but are also a result of natural erosion and decom...

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Autores principales:	Ann-Kathrin Vlacil, Sebastian Bänfer, Ralf Jacob, Nicole Trippel, Istemi Kuzu, Bernhard Schieffer, Karsten Grote
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d9131dd441e146cd98eef8460ec0f17a
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spelling	oai:doaj.org-article:d9131dd441e146cd98eef8460ec0f17a2021-11-25T06:13:53ZPolystyrene microplastic particles induce endothelial activation1932-6203https://doaj.org/article/d9131dd441e146cd98eef8460ec0f17a2021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598073/?tool=EBIhttps://doaj.org/toc/1932-6203Due to its increasing production, durability and multiple applications, plastic is a material we encounter every day. Small plastic particles from the μm to the mm range are classified as microplastics and produced for cosmetic and medical products, but are also a result of natural erosion and decomposition of macroplastics. Although being omnipresent in our environment and already detected in various organisms, less is known about the effects of microplastics on humans in general, or on vascular biology in particular. Here we investigated the effects of carboxylated polystyrene microplastic particles (PS, 1 μm) on murine endothelial and immune cells, which are both crucially involved in vascular inflammation, using in vitro and in vivo approaches. In vitro, PS induced adhesion molecule expression in endothelial cells with subsequent adhesion of leukocytes both under static and flow conditions. In monocytic cells, PS enhanced pro-inflammatory cytokine expression and release. Accordingly, administering mice with PS led to enhanced aortic expression of cytokines and adhesion molecules. Furthermore, we identified neutrophils as the PS-clearing blood leukocyte population. The findings from this study for the first time indicate polystyrene microplastic as a new environmental risk factor for endothelial inflammation.Ann-Kathrin VlacilSebastian BänferRalf JacobNicole TrippelIstemi KuzuBernhard SchiefferKarsten GrotePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ann-Kathrin Vlacil Sebastian Bänfer Ralf Jacob Nicole Trippel Istemi Kuzu Bernhard Schieffer Karsten Grote Polystyrene microplastic particles induce endothelial activation
description	Due to its increasing production, durability and multiple applications, plastic is a material we encounter every day. Small plastic particles from the μm to the mm range are classified as microplastics and produced for cosmetic and medical products, but are also a result of natural erosion and decomposition of macroplastics. Although being omnipresent in our environment and already detected in various organisms, less is known about the effects of microplastics on humans in general, or on vascular biology in particular. Here we investigated the effects of carboxylated polystyrene microplastic particles (PS, 1 μm) on murine endothelial and immune cells, which are both crucially involved in vascular inflammation, using in vitro and in vivo approaches. In vitro, PS induced adhesion molecule expression in endothelial cells with subsequent adhesion of leukocytes both under static and flow conditions. In monocytic cells, PS enhanced pro-inflammatory cytokine expression and release. Accordingly, administering mice with PS led to enhanced aortic expression of cytokines and adhesion molecules. Furthermore, we identified neutrophils as the PS-clearing blood leukocyte population. The findings from this study for the first time indicate polystyrene microplastic as a new environmental risk factor for endothelial inflammation.
format	article
author	Ann-Kathrin Vlacil Sebastian Bänfer Ralf Jacob Nicole Trippel Istemi Kuzu Bernhard Schieffer Karsten Grote
author_facet	Ann-Kathrin Vlacil Sebastian Bänfer Ralf Jacob Nicole Trippel Istemi Kuzu Bernhard Schieffer Karsten Grote
author_sort	Ann-Kathrin Vlacil
title	Polystyrene microplastic particles induce endothelial activation
title_short	Polystyrene microplastic particles induce endothelial activation
title_full	Polystyrene microplastic particles induce endothelial activation
title_fullStr	Polystyrene microplastic particles induce endothelial activation
title_full_unstemmed	Polystyrene microplastic particles induce endothelial activation
title_sort	polystyrene microplastic particles induce endothelial activation
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/d9131dd441e146cd98eef8460ec0f17a
work_keys_str_mv	AT annkathrinvlacil polystyrenemicroplasticparticlesinduceendothelialactivation AT sebastianbanfer polystyrenemicroplasticparticlesinduceendothelialactivation AT ralfjacob polystyrenemicroplasticparticlesinduceendothelialactivation AT nicoletrippel polystyrenemicroplasticparticlesinduceendothelialactivation AT istemikuzu polystyrenemicroplasticparticlesinduceendothelialactivation AT bernhardschieffer polystyrenemicroplasticparticlesinduceendothelialactivation AT karstengrote polystyrenemicroplasticparticlesinduceendothelialactivation
_version_	1718414013484761088

Polystyrene microplastic particles induce endothelial activation

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