A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease
Bone marrow adipocytes accumulate with age and in diverse disease states. However, their origins and adaptations in these conditions remain unclear, impairing our understanding of their context-specific endocrine functions and relationship with surrounding tissues. In this study, by analyzing bone a...
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eLife Sciences Publications Ltd
2021
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oai:doaj.org-article:d9134990e0d44b46aacdff55ba451e052021-11-16T14:07:24ZA bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease10.7554/eLife.662752050-084Xe66275https://doaj.org/article/d9134990e0d44b46aacdff55ba451e052021-08-01T00:00:00Zhttps://elifesciences.org/articles/66275https://doaj.org/toc/2050-084XBone marrow adipocytes accumulate with age and in diverse disease states. However, their origins and adaptations in these conditions remain unclear, impairing our understanding of their context-specific endocrine functions and relationship with surrounding tissues. In this study, by analyzing bone and adipose tissues in the lipodystrophic ‘fat-free’ mouse, we define a novel, secondary adipogenesis pathway that relies on the recruitment of adiponectin-negative stromal progenitors. This pathway is unique to the bone marrow and is activated with age and in states of metabolic stress in the fat-free mouse model, resulting in the expansion of bone marrow adipocytes specialized for lipid storage with compromised lipid mobilization and cytokine expression within regions traditionally devoted to hematopoiesis. This finding further distinguishes bone marrow from peripheral adipocytes and contributes to our understanding of bone marrow adipocyte origins, adaptations, and relationships with surrounding tissues with age and disease.Xiao ZhangHero RoblesKristann L MageeMadelyn R LorenzZhaohua WangCharles A HarrisClarissa S CraftErica L SchellereLife Sciences Publications Ltdarticleadipogenesisagingbone marrow adipocyteprogenitor cellsmetabolismadiponectinMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
adipogenesis aging bone marrow adipocyte progenitor cells metabolism adiponectin Medicine R Science Q Biology (General) QH301-705.5 |
| spellingShingle |
adipogenesis aging bone marrow adipocyte progenitor cells metabolism adiponectin Medicine R Science Q Biology (General) QH301-705.5 Xiao Zhang Hero Robles Kristann L Magee Madelyn R Lorenz Zhaohua Wang Charles A Harris Clarissa S Craft Erica L Scheller A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease |
| description |
Bone marrow adipocytes accumulate with age and in diverse disease states. However, their origins and adaptations in these conditions remain unclear, impairing our understanding of their context-specific endocrine functions and relationship with surrounding tissues. In this study, by analyzing bone and adipose tissues in the lipodystrophic ‘fat-free’ mouse, we define a novel, secondary adipogenesis pathway that relies on the recruitment of adiponectin-negative stromal progenitors. This pathway is unique to the bone marrow and is activated with age and in states of metabolic stress in the fat-free mouse model, resulting in the expansion of bone marrow adipocytes specialized for lipid storage with compromised lipid mobilization and cytokine expression within regions traditionally devoted to hematopoiesis. This finding further distinguishes bone marrow from peripheral adipocytes and contributes to our understanding of bone marrow adipocyte origins, adaptations, and relationships with surrounding tissues with age and disease. |
| format |
article |
| author |
Xiao Zhang Hero Robles Kristann L Magee Madelyn R Lorenz Zhaohua Wang Charles A Harris Clarissa S Craft Erica L Scheller |
| author_facet |
Xiao Zhang Hero Robles Kristann L Magee Madelyn R Lorenz Zhaohua Wang Charles A Harris Clarissa S Craft Erica L Scheller |
| author_sort |
Xiao Zhang |
| title |
A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease |
| title_short |
A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease |
| title_full |
A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease |
| title_fullStr |
A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease |
| title_full_unstemmed |
A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease |
| title_sort |
bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease |
| publisher |
eLife Sciences Publications Ltd |
| publishDate |
2021 |
| url |
https://doaj.org/article/d9134990e0d44b46aacdff55ba451e05 |
| work_keys_str_mv |
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