Chitosan-Based Biocompatible Copolymers for Thermoresponsive Drug Delivery Systems: On the Development of a Standardization System

Chitosan is a natural polysaccharide that is considered to be biocompatible, biodegradable and non-toxic. The polymer has been used in drug delivery applications for its positive charge, which allows for adhesion with and recognition of biological tissues via non-covalent interactions. In recent tim...

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Autores principales:	Lorenzo Marsili, Michele Dal Bo, Federico Berti, Giuseppe Toffoli
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	thermoresponsive polymers reproducibility chitosan drug delivery smart drug delivery systems poly-<i>N</i>-vinyl caprolactam Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/d919573ab21048d98eb6ec0ab08448db
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spelling	oai:doaj.org-article:d919573ab21048d98eb6ec0ab08448db2021-11-25T18:41:22ZChitosan-Based Biocompatible Copolymers for Thermoresponsive Drug Delivery Systems: On the Development of a Standardization System10.3390/pharmaceutics131118761999-4923https://doaj.org/article/d919573ab21048d98eb6ec0ab08448db2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1876https://doaj.org/toc/1999-4923Chitosan is a natural polysaccharide that is considered to be biocompatible, biodegradable and non-toxic. The polymer has been used in drug delivery applications for its positive charge, which allows for adhesion with and recognition of biological tissues via non-covalent interactions. In recent times, chitosan has been used for the preparation of graft copolymers with thermoresponsive polymers such as poly-<i>N</i>-vinylcaprolactam (PNVCL) and poly-<i>N</i>-isopropylamide (PNIPAM), allowing the combination of the biodegradability of the natural polymer with the ability to respond to changes in temperature. Due to the growing interest in the utilization of thermoresponsive polymers in the biological context, it is necessary to increase the knowledge of the key principles of thermoresponsivity in order to obtain comparable results between different studies or applications. In the present review, we provide an overview of the basic principles of thermoresponsivity, as well as a description of the main polysaccharides and thermoresponsive materials, with a special focus on chitosan and poly-<i>N</i>-Vinyl caprolactam (PNVCL) and their biomedical applications.Lorenzo MarsiliMichele Dal BoFederico BertiGiuseppe ToffoliMDPI AGarticlethermoresponsive polymersreproducibilitychitosandrug deliverysmart drug delivery systemspoly-<i>N</i>-vinyl caprolactamPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1876, p 1876 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	thermoresponsive polymers reproducibility chitosan drug delivery smart drug delivery systems poly-<i>N</i>-vinyl caprolactam Pharmacy and materia medica RS1-441
spellingShingle	thermoresponsive polymers reproducibility chitosan drug delivery smart drug delivery systems poly-<i>N</i>-vinyl caprolactam Pharmacy and materia medica RS1-441 Lorenzo Marsili Michele Dal Bo Federico Berti Giuseppe Toffoli Chitosan-Based Biocompatible Copolymers for Thermoresponsive Drug Delivery Systems: On the Development of a Standardization System
description	Chitosan is a natural polysaccharide that is considered to be biocompatible, biodegradable and non-toxic. The polymer has been used in drug delivery applications for its positive charge, which allows for adhesion with and recognition of biological tissues via non-covalent interactions. In recent times, chitosan has been used for the preparation of graft copolymers with thermoresponsive polymers such as poly-<i>N</i>-vinylcaprolactam (PNVCL) and poly-<i>N</i>-isopropylamide (PNIPAM), allowing the combination of the biodegradability of the natural polymer with the ability to respond to changes in temperature. Due to the growing interest in the utilization of thermoresponsive polymers in the biological context, it is necessary to increase the knowledge of the key principles of thermoresponsivity in order to obtain comparable results between different studies or applications. In the present review, we provide an overview of the basic principles of thermoresponsivity, as well as a description of the main polysaccharides and thermoresponsive materials, with a special focus on chitosan and poly-<i>N</i>-Vinyl caprolactam (PNVCL) and their biomedical applications.
format	article
author	Lorenzo Marsili Michele Dal Bo Federico Berti Giuseppe Toffoli
author_facet	Lorenzo Marsili Michele Dal Bo Federico Berti Giuseppe Toffoli
author_sort	Lorenzo Marsili
title	Chitosan-Based Biocompatible Copolymers for Thermoresponsive Drug Delivery Systems: On the Development of a Standardization System
title_short	Chitosan-Based Biocompatible Copolymers for Thermoresponsive Drug Delivery Systems: On the Development of a Standardization System
title_full	Chitosan-Based Biocompatible Copolymers for Thermoresponsive Drug Delivery Systems: On the Development of a Standardization System
title_fullStr	Chitosan-Based Biocompatible Copolymers for Thermoresponsive Drug Delivery Systems: On the Development of a Standardization System
title_full_unstemmed	Chitosan-Based Biocompatible Copolymers for Thermoresponsive Drug Delivery Systems: On the Development of a Standardization System
title_sort	chitosan-based biocompatible copolymers for thermoresponsive drug delivery systems: on the development of a standardization system
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d919573ab21048d98eb6ec0ab08448db
work_keys_str_mv	AT lorenzomarsili chitosanbasedbiocompatiblecopolymersforthermoresponsivedrugdeliverysystemsonthedevelopmentofastandardizationsystem AT micheledalbo chitosanbasedbiocompatiblecopolymersforthermoresponsivedrugdeliverysystemsonthedevelopmentofastandardizationsystem AT federicoberti chitosanbasedbiocompatiblecopolymersforthermoresponsivedrugdeliverysystemsonthedevelopmentofastandardizationsystem AT giuseppetoffoli chitosanbasedbiocompatiblecopolymersforthermoresponsivedrugdeliverysystemsonthedevelopmentofastandardizationsystem
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Chitosan-Based Biocompatible Copolymers for Thermoresponsive Drug Delivery Systems: On the Development of a Standardization System

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