Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen

Antigen distribution patterns affect thymic negative selection. Here, the authors show that incomplete thymic negative selection occurs to T cells for hematopoietic cell-restricted antigen H60 in mice, driving graft-versus-leukemia after H60-mismatched bone marrow transplantation.

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Autores principales:	Ji-Min Ju, Min Ho Jung, Giri Nam, Woojin Kim, Sehwa Oh, Hyun Duk Kim, Joo Young Kim, Jun Chang, Sung Hak Lee, Gyeong Sin Park, Chang-Ki Min, Dong-Sup Lee, Moon Gyo Kim, Kyungho Choi, Eun Young Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d91e7eb420e546c48be405524f865b4f
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spelling	oai:doaj.org-article:d91e7eb420e546c48be405524f865b4f2021-12-02T15:34:02ZEscape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen10.1038/s41467-017-02665-z2041-1723https://doaj.org/article/d91e7eb420e546c48be405524f865b4f2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02665-zhttps://doaj.org/toc/2041-1723Antigen distribution patterns affect thymic negative selection. Here, the authors show that incomplete thymic negative selection occurs to T cells for hematopoietic cell-restricted antigen H60 in mice, driving graft-versus-leukemia after H60-mismatched bone marrow transplantation.Ji-Min JuMin Ho JungGiri NamWoojin KimSehwa OhHyun Duk KimJoo Young KimJun ChangSung Hak LeeGyeong Sin ParkChang-Ki MinDong-Sup LeeMoon Gyo KimKyungho ChoiEun Young ChoiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ji-Min Ju Min Ho Jung Giri Nam Woojin Kim Sehwa Oh Hyun Duk Kim Joo Young Kim Jun Chang Sung Hak Lee Gyeong Sin Park Chang-Ki Min Dong-Sup Lee Moon Gyo Kim Kyungho Choi Eun Young Choi Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen
description	Antigen distribution patterns affect thymic negative selection. Here, the authors show that incomplete thymic negative selection occurs to T cells for hematopoietic cell-restricted antigen H60 in mice, driving graft-versus-leukemia after H60-mismatched bone marrow transplantation.
format	article
author	Ji-Min Ju Min Ho Jung Giri Nam Woojin Kim Sehwa Oh Hyun Duk Kim Joo Young Kim Jun Chang Sung Hak Lee Gyeong Sin Park Chang-Ki Min Dong-Sup Lee Moon Gyo Kim Kyungho Choi Eun Young Choi
author_facet	Ji-Min Ju Min Ho Jung Giri Nam Woojin Kim Sehwa Oh Hyun Duk Kim Joo Young Kim Jun Chang Sung Hak Lee Gyeong Sin Park Chang-Ki Min Dong-Sup Lee Moon Gyo Kim Kyungho Choi Eun Young Choi
author_sort	Ji-Min Ju
title	Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen
title_short	Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen
title_full	Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen
title_fullStr	Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen
title_full_unstemmed	Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen
title_sort	escape from thymic deletion and anti-leukemic effects of t cells specific for hematopoietic cell-restricted antigen
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d91e7eb420e546c48be405524f865b4f
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Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen

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