An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness
Activated Notch signalling promotes cancer metastasis and stemness. Here the authors show that Notch1 activates transcription of DNA replication factor RCF4 and that RCF4 binds and stabilises Notch1 intracellular domain (NICD1) to promote cancer metastasis.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/d91f2bc20dee437894291254ef20f4fc |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:d91f2bc20dee437894291254ef20f4fc |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:d91f2bc20dee437894291254ef20f4fc2021-12-02T14:35:32ZAn RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness10.1038/s41467-021-22971-x2041-1723https://doaj.org/article/d91f2bc20dee437894291254ef20f4fc2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22971-xhttps://doaj.org/toc/2041-1723Activated Notch signalling promotes cancer metastasis and stemness. Here the authors show that Notch1 activates transcription of DNA replication factor RCF4 and that RCF4 binds and stabilises Notch1 intracellular domain (NICD1) to promote cancer metastasis.Lei LiuTianyu TaoShihua LiuXia YangXuwei ChenJiaer LiangRuohui HongWenting WangYi YangXiaoyi LiYouhong ZhangQuanfeng LiShujun LiangHaocheng YuYun WuXinyu GuoYan LaiXiaofan DingHongyu GuanJueheng WuXun ZhuJie YuanJun LiShicheng SuMengfeng LiXiuyu CaiJunchao CaiHan TianNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Lei Liu Tianyu Tao Shihua Liu Xia Yang Xuwei Chen Jiaer Liang Ruohui Hong Wenting Wang Yi Yang Xiaoyi Li Youhong Zhang Quanfeng Li Shujun Liang Haocheng Yu Yun Wu Xinyu Guo Yan Lai Xiaofan Ding Hongyu Guan Jueheng Wu Xun Zhu Jie Yuan Jun Li Shicheng Su Mengfeng Li Xiuyu Cai Junchao Cai Han Tian An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness |
| description |
Activated Notch signalling promotes cancer metastasis and stemness. Here the authors show that Notch1 activates transcription of DNA replication factor RCF4 and that RCF4 binds and stabilises Notch1 intracellular domain (NICD1) to promote cancer metastasis. |
| format |
article |
| author |
Lei Liu Tianyu Tao Shihua Liu Xia Yang Xuwei Chen Jiaer Liang Ruohui Hong Wenting Wang Yi Yang Xiaoyi Li Youhong Zhang Quanfeng Li Shujun Liang Haocheng Yu Yun Wu Xinyu Guo Yan Lai Xiaofan Ding Hongyu Guan Jueheng Wu Xun Zhu Jie Yuan Jun Li Shicheng Su Mengfeng Li Xiuyu Cai Junchao Cai Han Tian |
| author_facet |
Lei Liu Tianyu Tao Shihua Liu Xia Yang Xuwei Chen Jiaer Liang Ruohui Hong Wenting Wang Yi Yang Xiaoyi Li Youhong Zhang Quanfeng Li Shujun Liang Haocheng Yu Yun Wu Xinyu Guo Yan Lai Xiaofan Ding Hongyu Guan Jueheng Wu Xun Zhu Jie Yuan Jun Li Shicheng Su Mengfeng Li Xiuyu Cai Junchao Cai Han Tian |
| author_sort |
Lei Liu |
| title |
An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness |
| title_short |
An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness |
| title_full |
An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness |
| title_fullStr |
An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness |
| title_full_unstemmed |
An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness |
| title_sort |
rfc4/notch1 signaling feedback loop promotes nsclc metastasis and stemness |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/d91f2bc20dee437894291254ef20f4fc |
| work_keys_str_mv |
AT leiliu anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT tianyutao anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT shihualiu anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT xiayang anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT xuweichen anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT jiaerliang anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT ruohuihong anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT wentingwang anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT yiyang anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT xiaoyili anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT youhongzhang anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT quanfengli anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT shujunliang anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT haochengyu anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT yunwu anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT xinyuguo anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT yanlai anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT xiaofanding anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT hongyuguan anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT juehengwu anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT xunzhu anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT jieyuan anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT junli anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT shichengsu anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT mengfengli anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT xiuyucai anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT junchaocai anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT hantian anrfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT leiliu rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT tianyutao rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT shihualiu rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT xiayang rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT xuweichen rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT jiaerliang rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT ruohuihong rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT wentingwang rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT yiyang rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT xiaoyili rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT youhongzhang rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT quanfengli rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT shujunliang rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT haochengyu rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT yunwu rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT xinyuguo rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT yanlai rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT xiaofanding rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT hongyuguan rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT juehengwu rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT xunzhu rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT jieyuan rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT junli rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT shichengsu rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT mengfengli rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT xiuyucai rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT junchaocai rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness AT hantian rfc4notch1signalingfeedbacklooppromotesnsclcmetastasisandstemness |
| _version_ |
1718391161870090240 |