Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization

Jørgensen et al. investigate the effects of the CXCR4 targeting agents, AMD3100 (Plerixafor) and AMD11070, and show that AMD3100, unlike AMD11070, is biased with intrinsic β-arrestin recruitment agonism and full G protein antagonism. They finally propose that this biased action of AMD3100 is central...

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Autores principales:	Astrid S. Jørgensen, Viktorija Daugvilaite, Katia De Filippo, Christian Berg, Masa Mavri, Tau Benned-Jensen, Goda Juzenaite, Gertrud Hjortø, Sara Rankin, Jon Våbenø, Mette M. Rosenkilde
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d920693ad8d842c78b29bd1b15141947
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spelling	oai:doaj.org-article:d920693ad8d842c78b29bd1b151419472021-12-02T17:15:22ZBiased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization10.1038/s42003-021-02070-92399-3642https://doaj.org/article/d920693ad8d842c78b29bd1b151419472021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02070-9https://doaj.org/toc/2399-3642Jørgensen et al. investigate the effects of the CXCR4 targeting agents, AMD3100 (Plerixafor) and AMD11070, and show that AMD3100, unlike AMD11070, is biased with intrinsic β-arrestin recruitment agonism and full G protein antagonism. They finally propose that this biased action of AMD3100 is central for its superior therapeutic effect on mobilizing stem cells.Astrid S. JørgensenViktorija DaugvilaiteKatia De FilippoChristian BergMasa MavriTau Benned-JensenGoda JuzenaiteGertrud HjortøSara RankinJon VåbenøMette M. RosenkildeNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Astrid S. Jørgensen Viktorija Daugvilaite Katia De Filippo Christian Berg Masa Mavri Tau Benned-Jensen Goda Juzenaite Gertrud Hjortø Sara Rankin Jon Våbenø Mette M. Rosenkilde Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization
description	Jørgensen et al. investigate the effects of the CXCR4 targeting agents, AMD3100 (Plerixafor) and AMD11070, and show that AMD3100, unlike AMD11070, is biased with intrinsic β-arrestin recruitment agonism and full G protein antagonism. They finally propose that this biased action of AMD3100 is central for its superior therapeutic effect on mobilizing stem cells.
format	article
author	Astrid S. Jørgensen Viktorija Daugvilaite Katia De Filippo Christian Berg Masa Mavri Tau Benned-Jensen Goda Juzenaite Gertrud Hjortø Sara Rankin Jon Våbenø Mette M. Rosenkilde
author_facet	Astrid S. Jørgensen Viktorija Daugvilaite Katia De Filippo Christian Berg Masa Mavri Tau Benned-Jensen Goda Juzenaite Gertrud Hjortø Sara Rankin Jon Våbenø Mette M. Rosenkilde
author_sort	Astrid S. Jørgensen
title	Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization
title_short	Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization
title_full	Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization
title_fullStr	Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization
title_full_unstemmed	Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization
title_sort	biased action of the cxcr4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d920693ad8d842c78b29bd1b15141947
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Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization

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