Effects of <i>Piper sarmentosum</i> on Metabolic Syndrome and Its Related Complications: A Review of Preclinical Evidence

<i>Piper sarmentosum</i> (PS) is a traditional medicinal herb used by South East Asians. It demonstrates promising properties against various non-communicable diseases and infectious agents due to its antioxidant and anti-inflammatory properties. Given that oxidative stress and inflammat...

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Autores principales:	Sophia Ogechi Ekeuku, Mohd Fahami Nur Azlina, Kok-Yong Chin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cholesterol inflammation oxidative stress hypertension obesity diabetes Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/d9228941723643019ea0f56bbfa66a17
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spelling	oai:doaj.org-article:d9228941723643019ea0f56bbfa66a172021-11-11T14:59:33ZEffects of <i>Piper sarmentosum</i> on Metabolic Syndrome and Its Related Complications: A Review of Preclinical Evidence10.3390/app112198602076-3417https://doaj.org/article/d9228941723643019ea0f56bbfa66a172021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/21/9860https://doaj.org/toc/2076-3417<i>Piper sarmentosum</i> (PS) is a traditional medicinal herb used by South East Asians. It demonstrates promising properties against various non-communicable diseases and infectious agents due to its antioxidant and anti-inflammatory properties. Given that oxidative stress and inflammation are involved in developing and exacerbating metabolic syndrome (MetS) and its principal components (central obesity, hyperglycaemia, hypertension, and dyslipidaemia), PS could manage MetS and its complications. This review summarises the available literature on the effects of PS on principal components of MetS and their complications. The accumulated evidence suggests that PS prevented adiposity, hyperglycaemia, hypertension, and dyslipidaemia in preclinical studies mainly through its antioxidant and anti-inflammatory properties. It also protected against MetS-associated cardiovascular complications. This review has identified research gaps in this field and suggested future studies to guide interested researchers to explore further or affirm the therapeutic potential of PS. One of the most significant challenges to the medical use of PS is the absence of randomised controlled trials in humans. This study gap must be bridged before PS supplementation could be used to manage MetS in humans.Sophia Ogechi EkeukuMohd Fahami Nur AzlinaKok-Yong ChinMDPI AGarticlecholesterolinflammationoxidative stresshypertensionobesitydiabetesTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 9860, p 9860 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cholesterol inflammation oxidative stress hypertension obesity diabetes Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	cholesterol inflammation oxidative stress hypertension obesity diabetes Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Sophia Ogechi Ekeuku Mohd Fahami Nur Azlina Kok-Yong Chin Effects of <i>Piper sarmentosum</i> on Metabolic Syndrome and Its Related Complications: A Review of Preclinical Evidence
description	<i>Piper sarmentosum</i> (PS) is a traditional medicinal herb used by South East Asians. It demonstrates promising properties against various non-communicable diseases and infectious agents due to its antioxidant and anti-inflammatory properties. Given that oxidative stress and inflammation are involved in developing and exacerbating metabolic syndrome (MetS) and its principal components (central obesity, hyperglycaemia, hypertension, and dyslipidaemia), PS could manage MetS and its complications. This review summarises the available literature on the effects of PS on principal components of MetS and their complications. The accumulated evidence suggests that PS prevented adiposity, hyperglycaemia, hypertension, and dyslipidaemia in preclinical studies mainly through its antioxidant and anti-inflammatory properties. It also protected against MetS-associated cardiovascular complications. This review has identified research gaps in this field and suggested future studies to guide interested researchers to explore further or affirm the therapeutic potential of PS. One of the most significant challenges to the medical use of PS is the absence of randomised controlled trials in humans. This study gap must be bridged before PS supplementation could be used to manage MetS in humans.
format	article
author	Sophia Ogechi Ekeuku Mohd Fahami Nur Azlina Kok-Yong Chin
author_facet	Sophia Ogechi Ekeuku Mohd Fahami Nur Azlina Kok-Yong Chin
author_sort	Sophia Ogechi Ekeuku
title	Effects of <i>Piper sarmentosum</i> on Metabolic Syndrome and Its Related Complications: A Review of Preclinical Evidence
title_short	Effects of <i>Piper sarmentosum</i> on Metabolic Syndrome and Its Related Complications: A Review of Preclinical Evidence
title_full	Effects of <i>Piper sarmentosum</i> on Metabolic Syndrome and Its Related Complications: A Review of Preclinical Evidence
title_fullStr	Effects of <i>Piper sarmentosum</i> on Metabolic Syndrome and Its Related Complications: A Review of Preclinical Evidence
title_full_unstemmed	Effects of <i>Piper sarmentosum</i> on Metabolic Syndrome and Its Related Complications: A Review of Preclinical Evidence
title_sort	effects of <i>piper sarmentosum</i> on metabolic syndrome and its related complications: a review of preclinical evidence
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d9228941723643019ea0f56bbfa66a17
work_keys_str_mv	AT sophiaogechiekeuku effectsofipipersarmentosumionmetabolicsyndromeanditsrelatedcomplicationsareviewofpreclinicalevidence AT mohdfahaminurazlina effectsofipipersarmentosumionmetabolicsyndromeanditsrelatedcomplicationsareviewofpreclinicalevidence AT kokyongchin effectsofipipersarmentosumionmetabolicsyndromeanditsrelatedcomplicationsareviewofpreclinicalevidence
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Effects of <i>Piper sarmentosum</i> on Metabolic Syndrome and Its Related Complications: A Review of Preclinical Evidence

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