Management practice, quality of life and associated factors in psoriasis patients attending a dermatological center in Ethiopia.

<h4>Background</h4>Psoriasis is a chronic inflammatory disease characterized by keratinocyte hyperproliferation and aberrant differentiation with great negative impact on patients' quality of life (QoL). This study aimed at assessing factors influencing management practice, and QoL...

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Autores principales:	Seefu Megarsa Kumsa, Tamrat Assefa Tadesse, Minyahil Alebachew Woldu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d92314910b204dab97cbb02347fce685
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spelling	oai:doaj.org-article:d92314910b204dab97cbb02347fce6852021-12-02T20:12:38ZManagement practice, quality of life and associated factors in psoriasis patients attending a dermatological center in Ethiopia.1932-620310.1371/journal.pone.0260243https://doaj.org/article/d92314910b204dab97cbb02347fce6852021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0260243https://doaj.org/toc/1932-6203<h4>Background</h4>Psoriasis is a chronic inflammatory disease characterized by keratinocyte hyperproliferation and aberrant differentiation with great negative impact on patients' quality of life (QoL). This study aimed at assessing factors influencing management practice, and QoL and its associated factors among ambulatory psoriatic patients visiting All Africa Leprosy, Tuberculosis and Rehabilitation Training (ALERT) Center in Addis Ababa, Ethiopia.<h4>Materials and methods</h4>A cross sectional study was conducted in 207 patients with psoriasis attending the dermatology clinic of ALERT Center in Addis Ababa, Ethiopia. Data were collected using structured questionnaire and patients' chart review. Dermatology Life Quality Index (DLQI) was used to measure patients' QoL. Patients' characteristics were summarized using descriptive statistics and predictors of QoL were identified by binary logistic regression.<h4>Results</h4>Among 207 study participants, 122 (58.9%) were females. The mean age of the study population was 37.92 (SD = 14.86) years (ranging from 16 to 68 years). The mean age at which diagnosis of psoriasis made was 32 (SD = 13.7) years ranging from 10 to 62 years. The duration of the disease in 112 (54.1%) patients were more than or equal to 5 years. Majority of study participants 145 (70.0%) had plaque psoriasis followed by sebopsoriasis, 24 (11.6%). The majority of plaque psoriasis (80%) cases were managed by topical corticosteroids with or without salicylic acid or coal tar and only 21 (14.5%) treated by methotrexate alone. The mean DLQI was 6.25 corresponding to a moderate effect. Symptoms and feelings were the most affected domains of QoL. Factors associated with poor QoL were female [AOR = 0.17 (95%CI: 0.06, 0.48)], low, above average and high family income ([AOR = 0.12 (95% CI: 0.02, 0.56)], [AOR = 0.06 (95% CI:0.01, 0.32)], and [AOR = 0.03 (95% CI: 0.01, 0.22)]), respectively, and primary education level [AOR = 0.14 (95% CI: 0.03, 0.64)] while being on systemic therapy [AOR = 4.26 (CI: 1.18, 15.35)] was predictor of better QoL. Poor QoL was predominant in females [AOR = 0.17 (95%CI: 0.06, 0.48)], low income [AOR = 0.12 (95% CI: 0.02, 0.56] patients, and patients with primary education level [AOR = 0.14 (95% CI: 0.03, 0.64)]. Patients on systemic therapy [AOR = 4.26 (CI: 1.18, 15.35)] had good QoL.<h4>Conclusion</h4>Our study identified that topical corticosteroids were the mainstay of psoriasis treatment in the dermatology clinic of ALERT Center in Addis Ababa, Ethiopia. Moderate effect QoL was achieved by study participants based on DLQL score.Seefu Megarsa KumsaTamrat Assefa TadesseMinyahil Alebachew WolduPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0260243 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seefu Megarsa Kumsa Tamrat Assefa Tadesse Minyahil Alebachew Woldu Management practice, quality of life and associated factors in psoriasis patients attending a dermatological center in Ethiopia.
description	<h4>Background</h4>Psoriasis is a chronic inflammatory disease characterized by keratinocyte hyperproliferation and aberrant differentiation with great negative impact on patients' quality of life (QoL). This study aimed at assessing factors influencing management practice, and QoL and its associated factors among ambulatory psoriatic patients visiting All Africa Leprosy, Tuberculosis and Rehabilitation Training (ALERT) Center in Addis Ababa, Ethiopia.<h4>Materials and methods</h4>A cross sectional study was conducted in 207 patients with psoriasis attending the dermatology clinic of ALERT Center in Addis Ababa, Ethiopia. Data were collected using structured questionnaire and patients' chart review. Dermatology Life Quality Index (DLQI) was used to measure patients' QoL. Patients' characteristics were summarized using descriptive statistics and predictors of QoL were identified by binary logistic regression.<h4>Results</h4>Among 207 study participants, 122 (58.9%) were females. The mean age of the study population was 37.92 (SD = 14.86) years (ranging from 16 to 68 years). The mean age at which diagnosis of psoriasis made was 32 (SD = 13.7) years ranging from 10 to 62 years. The duration of the disease in 112 (54.1%) patients were more than or equal to 5 years. Majority of study participants 145 (70.0%) had plaque psoriasis followed by sebopsoriasis, 24 (11.6%). The majority of plaque psoriasis (80%) cases were managed by topical corticosteroids with or without salicylic acid or coal tar and only 21 (14.5%) treated by methotrexate alone. The mean DLQI was 6.25 corresponding to a moderate effect. Symptoms and feelings were the most affected domains of QoL. Factors associated with poor QoL were female [AOR = 0.17 (95%CI: 0.06, 0.48)], low, above average and high family income ([AOR = 0.12 (95% CI: 0.02, 0.56)], [AOR = 0.06 (95% CI:0.01, 0.32)], and [AOR = 0.03 (95% CI: 0.01, 0.22)]), respectively, and primary education level [AOR = 0.14 (95% CI: 0.03, 0.64)] while being on systemic therapy [AOR = 4.26 (CI: 1.18, 15.35)] was predictor of better QoL. Poor QoL was predominant in females [AOR = 0.17 (95%CI: 0.06, 0.48)], low income [AOR = 0.12 (95% CI: 0.02, 0.56] patients, and patients with primary education level [AOR = 0.14 (95% CI: 0.03, 0.64)]. Patients on systemic therapy [AOR = 4.26 (CI: 1.18, 15.35)] had good QoL.<h4>Conclusion</h4>Our study identified that topical corticosteroids were the mainstay of psoriasis treatment in the dermatology clinic of ALERT Center in Addis Ababa, Ethiopia. Moderate effect QoL was achieved by study participants based on DLQL score.
format	article
author	Seefu Megarsa Kumsa Tamrat Assefa Tadesse Minyahil Alebachew Woldu
author_facet	Seefu Megarsa Kumsa Tamrat Assefa Tadesse Minyahil Alebachew Woldu
author_sort	Seefu Megarsa Kumsa
title	Management practice, quality of life and associated factors in psoriasis patients attending a dermatological center in Ethiopia.
title_short	Management practice, quality of life and associated factors in psoriasis patients attending a dermatological center in Ethiopia.
title_full	Management practice, quality of life and associated factors in psoriasis patients attending a dermatological center in Ethiopia.
title_fullStr	Management practice, quality of life and associated factors in psoriasis patients attending a dermatological center in Ethiopia.
title_full_unstemmed	Management practice, quality of life and associated factors in psoriasis patients attending a dermatological center in Ethiopia.
title_sort	management practice, quality of life and associated factors in psoriasis patients attending a dermatological center in ethiopia.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/d92314910b204dab97cbb02347fce685
work_keys_str_mv	AT seefumegarsakumsa managementpracticequalityoflifeandassociatedfactorsinpsoriasispatientsattendingadermatologicalcenterinethiopia AT tamratassefatadesse managementpracticequalityoflifeandassociatedfactorsinpsoriasispatientsattendingadermatologicalcenterinethiopia AT minyahilalebachewwoldu managementpracticequalityoflifeandassociatedfactorsinpsoriasispatientsattendingadermatologicalcenterinethiopia
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Management practice, quality of life and associated factors in psoriasis patients attending a dermatological center in Ethiopia.

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