Axin2-expressing cells differentiate into reparative odontoblasts via autocrine Wnt/β-catenin signaling in response to tooth damage

Abstract In non-growing teeth, such as mouse and human molars, primary odontoblasts are long-lived post-mitotic cells that secrete dentine throughout the life of the tooth. New odontoblast-like cells are only produced in response to a damage or trauma. Little is known about the molecular events that...

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Autores principales:	Rebecca Babb, Dhivya Chandrasekaran, Vitor Carvalho Moreno Neves, Paul T. Sharpe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d9285ee98fac493380c91a925421bf41
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spelling	oai:doaj.org-article:d9285ee98fac493380c91a925421bf412021-12-02T16:06:43ZAxin2-expressing cells differentiate into reparative odontoblasts via autocrine Wnt/β-catenin signaling in response to tooth damage10.1038/s41598-017-03145-62045-2322https://doaj.org/article/d9285ee98fac493380c91a925421bf412017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03145-6https://doaj.org/toc/2045-2322Abstract In non-growing teeth, such as mouse and human molars, primary odontoblasts are long-lived post-mitotic cells that secrete dentine throughout the life of the tooth. New odontoblast-like cells are only produced in response to a damage or trauma. Little is known about the molecular events that initiate mesenchymal stem cells to proliferate and differentiate into odontoblast-like cells in response to dentine damage. The reparative and regenerative capacity of multiple mammalian tissues depends on the activation of Wnt/β-catenin signaling pathway. In this study, we investigated the molecular role of Wnt/β-catenin signaling pathway in reparative dentinogenesis using an in vivo mouse tooth damage model. We found that Axin2 is rapidly upregulated in response to tooth damage and that these Axin2-expressing cells differentiate into new odontoblast-like cells that secrete reparative dentine. In addition, the Axin2-expressing cells produce a source of Wnt that acts in an autocrine manner to modulate reparative dentinogenesis.Rebecca BabbDhivya ChandrasekaranVitor Carvalho Moreno NevesPaul T. SharpeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rebecca Babb Dhivya Chandrasekaran Vitor Carvalho Moreno Neves Paul T. Sharpe Axin2-expressing cells differentiate into reparative odontoblasts via autocrine Wnt/β-catenin signaling in response to tooth damage
description	Abstract In non-growing teeth, such as mouse and human molars, primary odontoblasts are long-lived post-mitotic cells that secrete dentine throughout the life of the tooth. New odontoblast-like cells are only produced in response to a damage or trauma. Little is known about the molecular events that initiate mesenchymal stem cells to proliferate and differentiate into odontoblast-like cells in response to dentine damage. The reparative and regenerative capacity of multiple mammalian tissues depends on the activation of Wnt/β-catenin signaling pathway. In this study, we investigated the molecular role of Wnt/β-catenin signaling pathway in reparative dentinogenesis using an in vivo mouse tooth damage model. We found that Axin2 is rapidly upregulated in response to tooth damage and that these Axin2-expressing cells differentiate into new odontoblast-like cells that secrete reparative dentine. In addition, the Axin2-expressing cells produce a source of Wnt that acts in an autocrine manner to modulate reparative dentinogenesis.
format	article
author	Rebecca Babb Dhivya Chandrasekaran Vitor Carvalho Moreno Neves Paul T. Sharpe
author_facet	Rebecca Babb Dhivya Chandrasekaran Vitor Carvalho Moreno Neves Paul T. Sharpe
author_sort	Rebecca Babb
title	Axin2-expressing cells differentiate into reparative odontoblasts via autocrine Wnt/β-catenin signaling in response to tooth damage
title_short	Axin2-expressing cells differentiate into reparative odontoblasts via autocrine Wnt/β-catenin signaling in response to tooth damage
title_full	Axin2-expressing cells differentiate into reparative odontoblasts via autocrine Wnt/β-catenin signaling in response to tooth damage
title_fullStr	Axin2-expressing cells differentiate into reparative odontoblasts via autocrine Wnt/β-catenin signaling in response to tooth damage
title_full_unstemmed	Axin2-expressing cells differentiate into reparative odontoblasts via autocrine Wnt/β-catenin signaling in response to tooth damage
title_sort	axin2-expressing cells differentiate into reparative odontoblasts via autocrine wnt/β-catenin signaling in response to tooth damage
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d9285ee98fac493380c91a925421bf41
work_keys_str_mv	AT rebeccababb axin2expressingcellsdifferentiateintoreparativeodontoblastsviaautocrinewntbcateninsignalinginresponsetotoothdamage AT dhivyachandrasekaran axin2expressingcellsdifferentiateintoreparativeodontoblastsviaautocrinewntbcateninsignalinginresponsetotoothdamage AT vitorcarvalhomorenoneves axin2expressingcellsdifferentiateintoreparativeodontoblastsviaautocrinewntbcateninsignalinginresponsetotoothdamage AT paultsharpe axin2expressingcellsdifferentiateintoreparativeodontoblastsviaautocrinewntbcateninsignalinginresponsetotoothdamage
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Axin2-expressing cells differentiate into reparative odontoblasts via autocrine Wnt/β-catenin signaling in response to tooth damage

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