Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing

Ageing of the haematopoietic system is accompanied by declining erythropoiesis and lymphopoiesis. Here the authors uncover upregulated IL-6 and TGFβ signalling in aged bone marrow stroma; inhibition of these signals reverses age-related haematopoietic defects, re-balancing haematopoietic stem cell l...

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Autores principales:	Simona Valletta, Alexander Thomas, Yiran Meng, Xiying Ren, Roy Drissen, Hilal Sengül, Cristina Di Genua, Claus Nerlov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d92c05c8ae8e4f60abab394fce4e0c0b
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spelling	oai:doaj.org-article:d92c05c8ae8e4f60abab394fce4e0c0b2021-12-02T19:06:44ZMicro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing10.1038/s41467-020-17942-72041-1723https://doaj.org/article/d92c05c8ae8e4f60abab394fce4e0c0b2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17942-7https://doaj.org/toc/2041-1723Ageing of the haematopoietic system is accompanied by declining erythropoiesis and lymphopoiesis. Here the authors uncover upregulated IL-6 and TGFβ signalling in aged bone marrow stroma; inhibition of these signals reverses age-related haematopoietic defects, re-balancing haematopoietic stem cell lineage output.Simona VallettaAlexander ThomasYiran MengXiying RenRoy DrissenHilal SengülCristina Di GenuaClaus NerlovNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simona Valletta Alexander Thomas Yiran Meng Xiying Ren Roy Drissen Hilal Sengül Cristina Di Genua Claus Nerlov Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing
description	Ageing of the haematopoietic system is accompanied by declining erythropoiesis and lymphopoiesis. Here the authors uncover upregulated IL-6 and TGFβ signalling in aged bone marrow stroma; inhibition of these signals reverses age-related haematopoietic defects, re-balancing haematopoietic stem cell lineage output.
format	article
author	Simona Valletta Alexander Thomas Yiran Meng Xiying Ren Roy Drissen Hilal Sengül Cristina Di Genua Claus Nerlov
author_facet	Simona Valletta Alexander Thomas Yiran Meng Xiying Ren Roy Drissen Hilal Sengül Cristina Di Genua Claus Nerlov
author_sort	Simona Valletta
title	Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing
title_short	Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing
title_full	Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing
title_fullStr	Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing
title_full_unstemmed	Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing
title_sort	micro-environmental sensing by bone marrow stroma identifies il-6 and tgfβ1 as regulators of hematopoietic ageing
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d92c05c8ae8e4f60abab394fce4e0c0b
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Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing

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