Urocortin Role in Ischemia Cardioprotection and the Adverse Cardiac Remodeling

Despite the considerable progress in strategies of myocardial protection, ischemic heart diseases (IHD) and consequent heart failure (HF) remain the main cause of mortality worldwide. Several procedures are used routinely to guarantee the prompt and successful reestablishment of blood flow to preser...

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Autores principales:	Eva M. Calderón-Sánchez, Débora Falcón, Marta Martín-Bórnez, Antonio Ordoñez, Tarik Smani
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	urocortin adverse cardiac remodeling cardioprotection ischemia and reperfusion heart failure Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/d93463331ad3473597c5e079362b2480
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spelling	oai:doaj.org-article:d93463331ad3473597c5e079362b24802021-11-25T17:53:32ZUrocortin Role in Ischemia Cardioprotection and the Adverse Cardiac Remodeling10.3390/ijms2222121151422-00671661-6596https://doaj.org/article/d93463331ad3473597c5e079362b24802021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12115https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Despite the considerable progress in strategies of myocardial protection, ischemic heart diseases (IHD) and consequent heart failure (HF) remain the main cause of mortality worldwide. Several procedures are used routinely to guarantee the prompt and successful reestablishment of blood flow to preserve the myocardial viability of infarcted hearts from ischemia injuries. However, ischemic heart reperfusion/revascularization triggers additional damages that occur when oxygen-rich blood re-enters the vulnerable myocardial tissue, which is a phenomenon known as ischemia and reperfusion (I/R) syndrome. Complications of I/R injuries provoke the adverse cardiac remodeling, involving inflammation, mishandling of Ca<sup>2+</sup> homeostasis, apoptotic genes activation, cardiac myocytes loss, etc., which often progress toward HF. Therefore, there is an urgent need to develop new cardioprotective therapies for IHD and HF. Compelling evidence from animal studies and pilot clinical trials in HF patients suggest that urocortin (Ucn) isoforms, which are peptides associated with stress and belonging to the corticotropin releasing factor family, have promising potential to improve cardiovascular functions by targeting many signaling pathways at different molecular levels. This review highlights the current knowledge on the role of urocortin isoforms in cardioprotection, focusing on its acute and long-term effects.Eva M. Calderón-SánchezDébora FalcónMarta Martín-BórnezAntonio OrdoñezTarik SmaniMDPI AGarticleurocortinadverse cardiac remodelingcardioprotectionischemia and reperfusionheart failureBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12115, p 12115 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	urocortin adverse cardiac remodeling cardioprotection ischemia and reperfusion heart failure Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	urocortin adverse cardiac remodeling cardioprotection ischemia and reperfusion heart failure Biology (General) QH301-705.5 Chemistry QD1-999 Eva M. Calderón-Sánchez Débora Falcón Marta Martín-Bórnez Antonio Ordoñez Tarik Smani Urocortin Role in Ischemia Cardioprotection and the Adverse Cardiac Remodeling
description	Despite the considerable progress in strategies of myocardial protection, ischemic heart diseases (IHD) and consequent heart failure (HF) remain the main cause of mortality worldwide. Several procedures are used routinely to guarantee the prompt and successful reestablishment of blood flow to preserve the myocardial viability of infarcted hearts from ischemia injuries. However, ischemic heart reperfusion/revascularization triggers additional damages that occur when oxygen-rich blood re-enters the vulnerable myocardial tissue, which is a phenomenon known as ischemia and reperfusion (I/R) syndrome. Complications of I/R injuries provoke the adverse cardiac remodeling, involving inflammation, mishandling of Ca<sup>2+</sup> homeostasis, apoptotic genes activation, cardiac myocytes loss, etc., which often progress toward HF. Therefore, there is an urgent need to develop new cardioprotective therapies for IHD and HF. Compelling evidence from animal studies and pilot clinical trials in HF patients suggest that urocortin (Ucn) isoforms, which are peptides associated with stress and belonging to the corticotropin releasing factor family, have promising potential to improve cardiovascular functions by targeting many signaling pathways at different molecular levels. This review highlights the current knowledge on the role of urocortin isoforms in cardioprotection, focusing on its acute and long-term effects.
format	article
author	Eva M. Calderón-Sánchez Débora Falcón Marta Martín-Bórnez Antonio Ordoñez Tarik Smani
author_facet	Eva M. Calderón-Sánchez Débora Falcón Marta Martín-Bórnez Antonio Ordoñez Tarik Smani
author_sort	Eva M. Calderón-Sánchez
title	Urocortin Role in Ischemia Cardioprotection and the Adverse Cardiac Remodeling
title_short	Urocortin Role in Ischemia Cardioprotection and the Adverse Cardiac Remodeling
title_full	Urocortin Role in Ischemia Cardioprotection and the Adverse Cardiac Remodeling
title_fullStr	Urocortin Role in Ischemia Cardioprotection and the Adverse Cardiac Remodeling
title_full_unstemmed	Urocortin Role in Ischemia Cardioprotection and the Adverse Cardiac Remodeling
title_sort	urocortin role in ischemia cardioprotection and the adverse cardiac remodeling
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d93463331ad3473597c5e079362b2480
work_keys_str_mv	AT evamcalderonsanchez urocortinroleinischemiacardioprotectionandtheadversecardiacremodeling AT deborafalcon urocortinroleinischemiacardioprotectionandtheadversecardiacremodeling AT martamartinbornez urocortinroleinischemiacardioprotectionandtheadversecardiacremodeling AT antonioordonez urocortinroleinischemiacardioprotectionandtheadversecardiacremodeling AT tariksmani urocortinroleinischemiacardioprotectionandtheadversecardiacremodeling
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Urocortin Role in Ischemia Cardioprotection and the Adverse Cardiac Remodeling

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